脑梗死急性期患者血清MMP-9水平与认知功能障碍的关系

承德医学院学报 ›› 2017, Vol. 34 ›› Issue (1): 10-12.

脑梗死急性期患者血清MMP-9水平与认知功能障碍的关系

杨雪¹, 窦志杰^△, 王博¹, 李静¹

1.承德医学院,河北承德 067000;
2.承德医学院附属医院

收稿日期:2016-04-11 出版日期:2017-02-10 发布日期:2021-11-24

RELATIONSHIPS BETWEEN SERUM MMP-9 LEVEL AND COGNITIVE DYSFUNCTION OF PATIENTS WITH ACUTE CEREBRAL INFARCTION

YANG Xue, DOU Zhi-jie, WANG Bo, et al

Chengde Medical College, Hebei Chengde 067000, China

Received:2016-04-11 Online:2017-02-10 Published:2021-11-24

摘要/Abstract

摘要： 目的: 观察脑梗死急性期患者血清基质金属蛋白酶-9（MMP-9）水平与脑梗死后认知功能障碍的关系。方法: 首发脑梗死患者根据MoCA评分分为认知障碍组（<26分）、非认知障碍组（≥26分）,另选择同期健康体检者作为健康对照组。采用ELISA法测定124例受试者血清MMP-9水平。结果:认知障碍组血清MMP-9水平明显高于非认知障碍组和健康对照组（P<0.05）。Logistic回归分析显示,MMP-9、年龄是脑梗死后认知功能障碍的独立危险因素。结论: 脑梗死急性期患者血清MMP-9水平升高可能与脑梗死后认知功能障碍有关。

关键词: 脑梗死, 认知功能障碍, 基质金属蛋白酶-9（MMP-9）

Abstract: Objective: To observe the relationships between serum matrix metalloproteinase-9 (MMP-9) level and cognitive dysfunction after cerebral infarction of patients with acute cerebral infarction.Methods: Initial cerebral infarction patients were divided into cognitive dysfunction group (≤26) and non cognitive dysfunction group (<26) according to MoCA score. Healthy checkup at the same term were taken as healthy control group. ELISA was used to detect the serum MMP-9 level of 124 subjects. Results: The serum MMP-9 level of patients in cognitive dysfunction group was obviously higher than non cognitive dysfunction group and healthy control group (P<0.05). Logistic regression showed that MMP-9 and age were independent risk factors for cognitive dysfunction after cerebral infarction. Conclusions: Increasing of serum MMP-9 level in patients with acute cerebral infarction maybe related to cognitive dysfunction after cerebral infarction.

Key words: Cerebral infarction, Cognitive dysfunction, Matrix metalloproteinase-9 (MMP-9)

中图分类号:

R743.32

杨雪, 窦志杰, 王博, 李静. 脑梗死急性期患者血清MMP-9水平与认知功能障碍的关系[J]. 承德医学院学报, 2017, 34(1): 10-12.

YANG Xue, DOU Zhi-jie, WANG Bo, et al. RELATIONSHIPS BETWEEN SERUM MMP-9 LEVEL AND COGNITIVE DYSFUNCTION OF PATIENTS WITH ACUTE CEREBRAL INFARCTION[J]. Journal of Chengde Medical University, 2017, 34(1): 10-12.

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