人脑胶质瘤CD151的表达及其与胶质瘤病理分级的关系

承德医学院学报 ›› 2017, Vol. 34 ›› Issue (2): 95-97.

人脑胶质瘤CD151的表达及其与胶质瘤病理分级的关系

石凤云¹, 佟建洲^2,△

1.承德医学院,河北承德 067000;
2.保定市第一中心医院

收稿日期:2016-07-31 出版日期:2017-04-10 发布日期:2021-11-26

Received:2016-07-31 Online:2017-04-10 Published:2021-11-26

摘要/Abstract

摘要： 目的: 探讨人脑胶质瘤CD151的表达情况及其与胶质瘤病理分级的关系。方法: 采用免疫组化SP法检测56例人脑胶质瘤组织和15例正常人脑组织CD151的表达情况。结果: 正常脑组织CD151的阳性表达率为13.3%（2/15）,胶质瘤组脑组织CD151的阳性表达率为69.6%（39/56）,胶质瘤脑组织CD151的阳性表达率明显高于正常脑组织（P<0.05）;并且高级别脑胶质瘤组织CD151的阳性表达率明显高于低级别胶质瘤（P<0.05）。结论: CD151在脑胶质瘤中高表达,且阳性表达率随恶性程度的升高而增高。

中图分类号:

R739.41

石凤云, 佟建洲. 人脑胶质瘤CD151的表达及其与胶质瘤病理分级的关系[J]. 承德医学院学报, 2017, 34(2): 95-97.

参考文献

[1] Stedt H, Samaranayake H, Pikkarainen J, et al.Improved therapeutic effect on malignant glioma with adenoviral suicide gene therapy combined with temozolomide[J]. Gene Ther, 2013, 20(12):1165-1171.
[2] Tsai JC, Goldman CK, Gillespie GY.Vascular endothelial growth factor in human glioma cell lines: induced secretion by EGF, PDGF-BB, and bFGF[J]. J Neurosurg, 1995, 82(5):864-873.
[3] Lu H, Forbes RA, Verma A, et al.Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis[J]. J Bio1 Chem, 2002, 277(26):23111-23115.
[4] Folkman J.Tumor angiogenesis: therapeutic implications[J]. N En Med, 1971, 285(21):1182-1186.
[5] 蓝荣芳,刘正湘, 宋玉娥,等.CD151对人舌鳞癌细胞Tca8113迁移作用的影响[J].癌症,2005,24(3):262-267.
[6] Ke AW, Shi GM, Zhou J, et al.Role of overexpression of CD151 and/or c-Met in predicting prognosis of hepatocellular carcinoma
[J]. Hepatology, 2009, 49(2):491-503.
[7] Yang XH, Richardson AL, Torres-Arzayus MI, et al.CD151 accelerates breast cancer by regulating alpha 6 integrin function, signaling, and molecular organization[J]. Cancer Res, 2008, 68(9): 3204-3213.
[8] Zijlstra A, Lewis J, Degryse B, et al.The inhibition of tumor cell intravasation and subsequent metastasis via regulation of in vivo tumor cell motility by the tetraspanin CD151[J]. Cancer Cell, 2008, 13(3):221-234.
[9] 虞伟星,杨国良,章更生,等.四跨膜蛋白CD151在膀胱尿路上皮细胞癌中的表达及意义[J].肿瘤学杂志,2011,17(10):782-784.
[10] 王丽,杨军,刘正湘,等.CD151对大鼠心肌梗死后血管新生及心功能的影响[J].中华心血管杂志,2006,34(2):159-163.
[11] Shi GM, Ke AW, Zhou J, et al.CD151 modulates expression of matrix metalloproteinase 9 and promotes neoangiogenesis and progression of hepatocellular carcinoma[J]. Hepatology, 2010, 52(1): 183-196.
[12] Chung J, Mercurio AM.Contribution of the alpha6 integris to breast carcinoma survival and progression[J]. Mol Cells, 2004,17(2): 203-209.
[13] Rao Malla R, Gopinath S, Alapati K, et al.Knockdown of cathepsin B and uPAR inhibits CD151 and α3β1 integrin-mediated cell adhesion and invasion in glioma[J]. Mol Carcinog, 2013, 52(10): 777-790.