[1] 刘梦萱,张风霞,荀丽英.薯蓣皂苷元降血脂作用及其机制研究进展[J].中华中医药学刊,2016,34(4):798-800. [2] 仇华泉,苏酩,田景振.中药穿山龙治疗风湿病的研究进展[J].山东医药,2011,51(11):115-116. [3] Hu MM,Xu LN,Yin LH,et al.Cytotoxicity of dioscin in human gastric carcinoma cells through death receptor and mitochondrial pathways[J].J Appl Toxicol,2013,33(8):712-722. [4] 霍中华,胡君,储著陵,等.薯蓣皂苷元体内外抑制胃癌增殖的机制[J].江苏大学学报(医学版),2014,24(5):394-398. [5] Selim S,Al Jaouni S.Anticancer and apoptotic effects on cell proliferation of diosgenin isolated from Costus speciosus (Koen.) Sm[J].BMC Complement Altern Med,2015,15:301. [6] Kim DS,Jeon BK,Lee YE,et al.Diosgenin induces apoptosis in HepG2 cells through generation of reactive oxygen species and mitochondrial pathway[J].Evid Based Complement Alternat Med,2012,2012:981675. [7] Cailleteau C,Micallef L,Lepage C,et al.Investigating the relationship between cell cycle stage and diosgenin-induced megakaryocytic differentiation of HEL cells using sedimentation field-flow fractionation[J].Anal Bioanal Chem,2010,398(3):1273-1283. [8] Ghezali L,Leger DY,Limami Y,et al.Cyclopamine and jervine induce COX-2 overexpression in human erythroleukemia cells but only cyclopamine has a proapoptotic effect[J].Exp Cell Res, 2013,319(7):1043-1053. [9] 林杰,谈永飞,马铁梁,等.薯蓣皂苷元通过MAPK通路对食管癌细胞Cca109[J].世界华人消化杂志,2013,21(35):3977-3982. [10] Lepage C,Léger DY,Bertrand J,et al.Diosgenin induces death receptor-5 through activation of p38 pathway and promotes TRAIL-induced apoptosis in colon cancer cells[J].Cancer Lett, 2011,301(2):193-202. [11] Li Y,Wang X,Cheng S,et al.Diosgenin induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma cells[J].Oncol Rep,2015,33(2):693-698. [12] Nantajit D, Fan M, Duru N, et al.Cyclin B1/Cdk1 phosphorylation of mitochondrial p53 induces anti-apoptotic response[J].PLoS One,2010,5(8):e12341. [13] Chen H,Xu L,Yin L,et al.iTRAQ-based proteomic analysis ofdioscin on human HCT-116 colon cancer cells[J].Proteomics,2014,14(1):51-73. [14] Hamid AA,Hasanain M,Singh A,et al.Synthesis of novel anticancer agents through opening of spiroacetal ring of diosgenin[J].Steroids,2014,87:108-118. [15] 张文秀. 薯蓣皂苷元对人宫颈癌细胞增殖的影响[J].中国现代医生,2011,49(26 ):5-7. [16] He Z, Chen H, Li G, et al.Diosgenin inhibits the migration of human breast cancer MDA-MB-231 cells by suppressing Vav2 activity[J].Phytomedicine,2014,21(6):871-876. [17] Aumsuwan P,Khan SI,Khan IA,et al.The anticancer potential of steroidal saponin,dioscin, isolated from wild yam (Dioscoreavillosa) root extract in invasive human breast cancer cell line MDA-MB-231 in vitro[J].Arch Biochem Biophys,2016,591:98-110. [18] Ding W,Jiang Y,Jiang Y,et al.Role of SB203580 in the regulation of human esophageal cancer cells under the effection of Diosgenin[J].Int J Clin Exp Med,2015,8(2):2476-2479. [19] Chen PS,Shih YW,Huang HC,et al.Diosgenin,a steroidal saponin,inhibits migration and invasion of human prostate cancer PC-3 cells by reducing matrix metalloproteinases expression[J]. PLoS One,2011,6(5):e20164. [20] 吴媛媛,崔国兴,马铁梁,等.薯蓣皂苷元对人胃癌 BGC-823 和 SGC-7901 细胞生物学行为的影响[J]. 江苏大学学报(医学版),2014,24(3):207-210. [21] Rahmati-Yamchi M,Ghareghomi S,Haddadchi G,et al.Fenugreek extract diosgenin and pure diosgenin inhibit the hTERT gene expression in A549 lung cancer cell line[J].Mol Biol Rep, 2014,41(9):6247-6252. [22] Mohammad RY,Somayyeh G,Gholamreza H,et al.Diosgenin inhibits hTERT gene expression in the A549 lung cancer cell line[J].Asian Pac J Cancer Prev,2013,14(11):6945-6948. [23] Ghezali L,Liagre B,Limami Y,et al.Sonic hedgehog activation is implicated in diosgenin- induced megakaryocytic differentiation of human erythroleukemia cells[J].PLoS One,2014, 9(4):e95016. [24] 何焱,王继双,张鹏,等.薯蓣皂苷元联合 TRAIL 对非小细胞肺癌 A549 细胞的协同作用及其中效原理评价[J].药学学报,2013,48(1):45-51. [25] Lepage C,Léger DY,Bertrand J,et al.Diosgenin induces death receptor-5 through activation of p38 pathway and promotes TRAIL-induced apoptosis in colon cancer cells[J].Cancer Lett,2011, 301(2):193-202. [26] Das S,Dey KK,Dey G,et al.Antineoplastic and apoptotic potential of traditional medicines thymoquinone and diosgenin in squamous cell carcinoma[J].PLoS One,2012,7(10):e46641. [27] Wang L, Meng Q, Wang C, et al.Dioscin restores the activity of the anticancer agent adriamycin in multidrug-resistant human leukemia K562/adriamycin cells by down-regulating MDR1 via a mechanism involving NF-kappa B signaling inhibition[J].J Nat Prod,2013,76(5):909-914. [28] Al-Daghri NM,Alokail MS,Alkharfy KM,et al.Fenugreek extract as an inducer of cellular death via autophagy in human T lymphoma Jurkat cells[J].BMC Complementary Altern Med,2012,12:202. [29] Jiang S,Fan J,Wang Q,et al.Diosgenin induces ROS-dependent autophagy and cytotoxicity via mTOR signaling pathway in chronic myeloid leukemia cells[J].Phytomedicine,2016,23(3):243-252. |