[1] 黄劬,刘殿阁,宋文娟,等.2型糖尿病肾病微炎症反应与急性脑梗死关系的研究[J].现代医学,2010,38(6):603-606. [2] National Kidney Foundation.KDOQI Clinical Practice Guideline for Diabetes and CDK:2012 Update[J].Am J Kidney Dis,2012,60(5):850-886. [3] Chen X,Chen Q,Wang L,et al.Ghrelin induces cell migration through GHSR1a-mediated PI3K/Akt/eNOS/NO signaling pathway in endothelial progenitor cells[J].Metabolism,2013,62(5):743-752. [4] Matsuda S,Nakanishi A,Wada Y,et al.Roles of PI3K/Akt/PTEN pathway as a target for pharmaceutical therapy[J].Open Med Chem J,2013,31(7):23-29. [5] Liu P,Cheng H,Roberts TM,et al.Targeting the phosphoinositide 3-kinase pathway in cancer[J].Nat Rev Drug Discov,2009,8(8):627-644. [6] 杨宁,王恬,惠起源.PI3K-Akt信号通路与胃癌的研究进展[J].现代肿瘤医学,2010,18(1):197-200. [7] Gim SA,Sung JH,Shah FA,et al.Ferulicacid regulates the AKT/GSK-3β/CRMP-2 signaling pathway in a middle cerebral artery occlusion animal model[J].Lab Anim Res,2013,29(2):63-69. [8] Shamji AF,Nghiem P,Schreiber SL.Integration of growth factor and nutrient signaling: implications for cancer biology[J].Mol Cell,2003,12(2):271-280. [9] 赵婧,屈艺,母得志.PTEN/PI3K/AKT信号节点与血管生成研究进展[J].广东医学,2010,31(19):2595-2597. [10] Braehmann SM,Ueki K,Engelman JA,et a1.Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice[J].Mol Cell Biol,2005,25(5):1596-1607. [11] Engelman JA,Luo J,Cantley LC.The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism[J].Nat Rev Genet,2006,7(8):606-619. [12] Zheng W,Nagaraju G,Liu Z,et al.Functional roles of the phosphatidylinositol 3-kinases (PI3Ks) signaling in the mammalian ovary[J].Mol Cell Endocrinol,2012,356(1):24-30. [13] Du K,Tsichlis PN.Regulation of the Akt kinase by interacting proteins[J]. Oncogene,2005,24(50):7401-7409. [14] Woodgett JR.Recent advances in the protein kinase B signaling pathway[J].Curr Opin Cell Biol,2005,179(2):150-157. [15] 李晓瑾,母义明.Akt信号通路在胰岛β细胞功能中的研究进展[J].医学综述,2012,18(8):1121-1124. [16] Elghazi L,Bernal-Mizrachi E.Akt and PTEN:beta-cell mass and pancreas plasticity[J].Trends Endocrinol Metab,2009,20(5):243-251. [17] 黄丽艳,王娜,汤黎明,等.PTEN基因表达对EC9706细胞增殖、侵袭、凋亡能力的影响[J].郑州大学学报(医学版),2013,48(1):16-20. [18] Steck PA,Pershouse MA,Jasser SA,et al.Identification of a candidate tumor suppressor gene,MMAC1,at chromosome 10q23.3 that is mutated in multiple advanced cancers[J].Nature Genetics,1997,15(4):356-362. [19] Li DM,Sun H.TEP1,encoded by a candidate tumor suppressor locus,is a novel protein tyrosine phosphatase regulated by transforming growth factor beta[J].Cancer Res,1997,57(11):2124-2129. [20] Li J,Yen C,Liaw D,et al.PTEN,a putative protein tyrosine phosphatase gene mutated in human brain,breast,and prostate cancer[J].Science,1997,275(5308):1943-1947. [21] Hlobilková A,Knillová J,Bártek J,et al.The mechanism of action of the tumour suppressor gene PTEN[J].Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub,2003,147(1):19-25. [22] Vazquez F,Grossman SR,Takahashi Y,et al.Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex[J].J Biol Chem,2001,276(52):48627-48630. [23] Vazquez F,Ramaswamy S,Nakamura N,et al.Phosphorylation of the PTEN tail regulates protein stability and function[J].Mol Cell Biol,2000,20(14):5010-5018. [24] Cully M,You H,Levine AJ,et al.Beyond PTEN mutations:the PI3K pathway as an integrator of multiple inputs during tumorigenesis[J].Nat Rev Cancer,2006,6(3):184-192. [25] Brucka A,Szyllo K.Immunoexpression of the PTEN protein and matrix metalloproteinase-2 in endometrial cysts,endometrioid and clear cell ovarian cancer[J].Ginekol Pol,2013,84(5):344-351. [26] Myers AP.New strategies in endometrial cancer:targeting the PI3K/mTOR pathway-the devil is in the detail[J].Clin Cancer Res,2013,19(19):5264-5274. [27] Ciuffreda L,Falcone I,Incani UC,et al.PTEN expression and function in adult cancer stem cells and prospects for therapeutic targeting[J].Adv Biol Regul,2014,56:66-80. [28] Laurenta PA,Severina S,Gratacapa MP,et al.Class I PI3-kinases signaling in platelet activation and thrombosis:PDK1/Akt/GSK3 axis and impact of PTEN and SHIP1[J].Adv Biol Regul,2014,54:162-174. [29] 张翠香,洪晓华,侯金才,等.链脲佐菌素糖尿病肾病大鼠模型肾小球损伤机制[J].中华中医药杂志,2015,30(9):3087-3091. [30] Kasinath BS,Mariappan MM,Sataranatarajan K,et al.Novel mechanisms of protein synthesis in diabetic nephropathy-role of mRNA translation[J].Rev Endocr Metab Disord,2008,9(4):255-266. [31] Eid AA,Ford BM,Block K,et al.AMP-activated protein kinase (AMPK) negatively regulates Nox4-dependent activation of p53 and epithelial cell apoptosis in diabetes[J].J Biol Chem,2010,285(48):37503-37512. [32] 邢玲玲,刘青娟,傅淑霞,等.高糖和LY294002干预影响足细胞内Ⅳ型胶原表达[J].中国细胞生物学报,2011,33(11):1237-1240. [33] Wang XM,Yao M,Liu SX.Interplay between the Notch and PI3K/Akt pathways in high glucose induced podocyte apoptosis[J].Am J Physiol Renal Physiol,2014,306(2):F205-F213. [34] Kattla JJ,Carew RM,Heljic M,et al.Protein Kinase B/Akt activity is involved in renal TGF-β1-driven epithelial-mesenchymal transition in vitro and in vivo[J].Am J Physiol Renal Physiol,2008,295(1):F215-F225. [35] 张政,彭惠民,徐晓明,等.糖尿病肾病相关微小RNA对高糖下肾小球系膜细胞增殖的影响及其机制[J].中国生物制品学杂志,2010,23(8):821-824. [36] Mahimainathan L,Das F,Venkatesan B,et al.Mesangial cell hypertrophy by high glucose is mediated by down regulation of the tumor suppressor PTEN[J].Diabetes,2006,55(7):2115-2125. [37] 邢玲玲,傅淑霞,杨林,等.PTEN在糖尿病肾病患者足细胞损伤中的作用[J].临床与实验病理学杂志,2014,30(12):1375-1378. [38] Sireesha M,Sambasivan V,Kumar VK,et al.Relevance of insulin-like growth factor 2 in the etiopathophysiology of diabetic nephropathy:possible roles of phosphatase and tensin homolog on chromosome 10 and secreted protein acidic and rich in cysteine as regulators of repair[J].J Diabetes,2009,1(2):118-124. [39] Welsh GI,Hale LJ,Eremina V,et al.Insulin signaling to the glomerular podocyte is critical for normal kidney function[J].Cell Metab,2010,12(4):329-340. [40] Sheikh AQ,Hurley JR,Huang W,et al.Diabetes alters intracellular calcium transients in cardiac endothelial cells[J].PloS One,2012,7(5):e36840. [41] 杨辰,尹德海,朴元林,等.黄芪菟箭合剂对糖尿病大鼠肾脏PI3K-Akt-mTOR信号通路的影响[J].中国中西医结合肾病杂志,2016,17(10):862-866. [42] 程悦,王代红,张耀全,等.PTEN编码蛋白对TGF-β1刺激大鼠肾成纤维细胞分泌ColⅣ、FN的抑制作用[J].解放军医学杂志,2007,32(7):719-721. [43] 位红兰,曾锐,刘林,等.高表达PTEN抑制TGF-β1诱导的肾小管上皮细胞转分化[J].华中科技大学学报(医学版),2009,38(6):721-724. [44] Shemesh II,Rozen-Zvi B,Kalechman Y,et al.AS101 prevents diabetic nephropathy progression and mesangial cell dysfunction:regulation of the AKT downstream pathway[J].PLoS One,2014,9(12):e114287. |