关键词: 结直肠癌, 胰岛素样生长因子结合蛋白-3, 基质金属蛋白酶-14, 免疫组织化学

Abstract: Objective: To investigate the expression and clinical significance of insulin-like growth factor binding protein-3 (IGFBP-3) and matrix metalloproteinases-14 (MMP-14) in colorectal cancer (CRC). Methods: Immunohistochemical staining was used to detect the expression of IGFBP-3 and MMP-14 in 70 cases of CRC, 30 cases of colorectal adenoma (CRA) and 20 cases of normal colorectal mucosa (NM). The relationships between IGFBP-3, MMP-14 and clinical pathological features of CRC, as well as the correlations between IGFBP-3 and MMP-14 in CRC were analyzed. Results: In CRC, the MMP-14 protein expression was obviously higher than CRA and NM; the MMP-14 expression was concerned with depth of invasion, lymph node metastasis and Dukes stage (P<0.01, P<0.05). In CRC, the IGFBP-3 protein expression was obviously lower than CRA and NM; the IGFBP-3 expression was concerned with lymph node metastasis and Dukes stage (P<0.05). In CRC, the expression of MMP-14 was negatively correlated with the expression of IGFBP-3 (r=-0.460, P<0.05). Conclusions: IGFBP-3 and MMP-14 may have synergistic effects and participate in the process of development, invasion and metastasis of CRC jointly.

Key words: Colorectal cancer (CRC), Insulin-like growth factor binding protein-3 (IGFBP-3), Matrix metalloproteinases-14 (MMP-14), Immunohistochemistry