高血压脑出血患者血清TNF-α、VEGF、ET-1水平的变化及意义*

承德医学院学报 ›› 2018, Vol. 35 ›› Issue (4): 296-298.

高血压脑出血患者血清TNF-α、VEGF、ET-1水平的变化及意义^*

刘思洋, 吴建龙, 乔建勇^△, 张艳利

承德市中心医院,河北承德 067000

收稿日期:2017-12-30 出版日期:2018-08-10 发布日期:2021-11-21
通讯作者: △
基金资助:
* 河北省2016年度医学科学研究指令性重点课题（20160007）

CHANGES AND SIGNIFICANCE OF SERUM TNF-Α, VEGF AND ET-1 LEVEL IN PATIENTS WITH HYPERTENSIVE CEREBRAL HEMORRHAGE

LIU Si-yang, WU Jian-long, QIAO Jian-yong, et al

Chengde Central Hospital, Hebei Chengde 067000, China

Received:2017-12-30 Online:2018-08-10 Published:2021-11-21

摘要/Abstract

摘要： 目的: 探讨高血压脑出血(hypertensive cerebral hemorrhage,HICH)患者血清肿瘤坏死因子-α(TNF-α)、血管内皮生长因子(VEGF)和内皮素-1(ET-1)水平的变化及临床意义。方法: 采用ELISA法检测HICH患者及健康体检者血清TNF-α、VEGF和ET-1的水平,并分析不同GCS评分HICH患者血清TNF-α、VEGF和ET-1水平的变化情况。结果: HICH患者血清TNF-α、VEGF和ET-1水平均明显高于健康体检者(P<0.05)。并且,随着HICH患者GCS评分的降低,血清TNF-α、VEGF和ET-1水平逐渐升高（P<0.05）。结论: 检测HICH患者血清TNF-α、VEGF和ET-1水平,对于HICH患者病情和预后判断有重要意义。

关键词: 高血压脑出血, 肿瘤坏死因子-α, 血管内皮生长因子, 内皮素-1

Abstract: Objective:To investigate the changes and clinical significance of serum tumor necrosis factor-α (TNF-α), vascular endothelial growth factor (VEGF) and endothelin-1 (ET-1) level in patients with hypertensive cerebral hemorrhage (HICH). Methods:ELISA was used to detect the serum TNF-α, VEGF and ET-1 level of HICH patients and healthy controls; And the serum TNF-α, VEGF and ET-1 level of HICH patients with different GCS scores were analyzed. Results:The serum TNF-α, VEGF and ET-1 level of HICH patients were significantly higher than healthy controls (P<0.05). Along with decreasing of GCS score in HICH patients, the serum TNF-α, VEGF and ET-1 level gradually increased (P<0.05). Conclusions:Detection of serum TNF-α, VEGF and ET-1 level play important role in diagnosis and prognosis of HICH patients.

Key words: Hypertensive cerebral hemorrhage, Tumor necrosis factor-α (TNF-α), Vascular endothelial growth factor (VEGF), Endothelin-1 (ET-1)

中图分类号:

R743.34

刘思洋, 吴建龙, 乔建勇, 张艳利. 高血压脑出血患者血清TNF-α、VEGF、ET-1水平的变化及意义^*[J]. 承德医学院学报, 2018, 35(4): 296-298.

LIU Si-yang, WU Jian-long, QIAO Jian-yong, et al. CHANGES AND SIGNIFICANCE OF SERUM TNF-Α, VEGF AND ET-1 LEVEL IN PATIENTS WITH HYPERTENSIVE CEREBRAL HEMORRHAGE[J]. Journal of Chengde Medical University, 2018, 35(4): 296-298.

参考文献

[1] Jenson AV, Rodriguez GJ, Alvarado LA, et al.Higher rate of intracerebral hemorrhage in Hispanic patients with cerebral cavernous malformation[J]. J Vasc Interv Neurol, 2015, 8(4): 1-4.
[2] 杨继文,龚树辉,张利民,等.脑出血后炎症反应的研究进展[J].脑与神经疾病杂志,2009,17(4):317-319.
[3] 中华医学会神经外科学分会,中国医师协会急诊医师分会,国家卫生和计划生育委员会脑卒中筛查与防治工程委员会.自发性脑出血诊断治疗中国多学科专家共识[J].中华神经外科杂志,2015,31(12):1189-1194.
[4] 王宏,王义宏,游洋,等.高血压脑出血后血浆脂联素浓度变化及其与炎症因子相关性研究[J].南京医科大学学报(自然科学版),2012,32(3):378-381.
[5] Ewen T, Qiuting L, Chaogang T, et al.Neuroprotective effect of atorvastatin involves suppression of TNF-alpha and upregulation of IL-10 in a rat model of intracerebral hemorrhage[J]. Cell Biochem Biophys, 2013, 66(2): 337-346.
[6] 杨茜,罗永杰.血管内皮生长因子与脑出血的关系研究进展[J].实用医院临床杂志,2014,11(3): 204-206.
[7] Kimura R, Nakase H, Tamaki R, et al.Vascular endothelial growth factor antagonist reduces brain edema formation and venous infarction[J]. Stroke, 2005, 36(6): 1259-1263.
[8] Lennmyr F, Terént A, Syvänen AC, et al.Vascular endothelial growth factor gene expression in middle cerebral artery occlusion in the rat[J]. Acta Anaesthesiol Scand, 2005, 49(4): 488-493.
[9] 李海燕,张祥建,张丽英,等.实验性脑出血大鼠脑组织血管内皮生长因子的表达及意义[J].中国全科医学,2004,7(15):1046-1048.
[10] Shin JA, Yang SJ, Jeong SI, et al.Activation of estrogen receptor β reduces blood-brain barrier breakdown following ischemic injury[J]. Neuroscience, 2013, 235: 165-173.
[11] 周晓明,周梦良,张鑫,等.内皮素-1与蛛网膜下腔出血后脑血管痉挛[J].国际脑血管病杂志,2012,20(8):637-640.
[12] Masaki T, Kimura S, Yanagisawa M, et al.Molecular and cellular mechanism of endothelium regulation. Implications for vascular function[J]. Circulation, 1991, 84(4): 1457-1468.
[13] 张欢欢,韩冰,廉银珠,等.不同水平高血压患者血清Klotho蛋白、NO、ET-1的表达水平及相关性[J].中国老年学杂志,2015,35(3):596-599.