载脂蛋白B/A1、糖化血红蛋白水平与脑梗死静脉溶栓结局的关系

承德医学院学报 ›› 2019, Vol. 36 ›› Issue (1): 11-15.

载脂蛋白B/A1、糖化血红蛋白水平与脑梗死静脉溶栓结局的关系

陈肖, 张云鹏, 窦志杰^△, 张晓璇

承德医学院附属医院神经内科,河北承德 067000

收稿日期:2018-09-10 出版日期:2019-02-10 发布日期:2021-11-18
通讯作者: △

RELATIONSHIPS BETWEEN APOLIPOPROTEIN B/A1, GLYCOSYLATED HEMOGLOBIN LEVEL AND VENOUS THROMBOLYSIS OUTCOME IN CEREBRAL INFARCTION PATIENTS

CHEN Xiao, ZHANG Yun-peng, DOU Zhi-jie, et al

Department of Neurology, the Affiliated Hospital of Chengde Medical College, Hebei Chengde 067000, China

Received:2018-09-10 Online:2019-02-10 Published:2021-11-18

摘要/Abstract

摘要： 目的:分析载脂蛋白B/A1、糖化血红蛋白（HbA1c）水平与急性脑梗死患者静脉溶栓结局的关系。方法:76例急性脑梗死患者使用重组组织型纤溶酶原激活剂（rt-PA）静脉溶栓治疗,根据溶栓前后NIHSS评分改善情况分为无效组27例和显效组49例。分别检测两组受试者血糖、血脂、HbA1c等指标,并分析影响溶栓结局的危险因素。结果:显效组HbA1c、ApoB、ApoB/A1明显低于无效组,ApoA1明显高于无效组（P<0.05）;Logistic回归分析显示,年龄、HbA1c、ApoB/A1是影响溶栓结局的独立危险因素（P<0.05）。结论:ApoB/A1和HbA1c可能在早期预测急性脑梗死患者的溶栓结局具有一定价值。

关键词: 急性脑梗死, 静脉溶栓, 糖化血红蛋白, 载脂蛋白

Abstract: Objective: To analyze the relationships between apolipoprotein B/A1, glycosylated hemoglobin (HbA1c) level and venous thrombolytic outcome in acute cerebral infarction patients. Methods: 76 acute cerebral infarction patients were all treated with recombinant tissue plasminogen activator (rt-PA) venous thrombolysis, and the patients were divided into ineffective group (n=27) and effective group (n=49) according to improvement of NIHSS score before and after thrombolysis. The blood glucose, blood lipid, HbA1c and other indicators of all the patients were detected. Results: The HbA1c, ApoB and ApoB/A1 of patients in effective group were significantly lower than ineffective group, the ApoA1 was significantly higher (P<0.05). Logistic regression analysis showed that age, HbA1c and ApoB/A1 were independent risk factors for thrombolytic outcome (P<0.05). Conclusions: ApoB/A1 and HbA1c may has certain predicting value for thrombolytic outcome in acute cerebral infarction patients at early stage.

Key words: Acute cerebral infarction, Venous thrombolysis, Glycated hemoglobin, Apolipoprotein

中图分类号:

R743.3

陈肖, 张云鹏, 窦志杰, 张晓璇. 载脂蛋白B/A1、糖化血红蛋白水平与脑梗死静脉溶栓结局的关系[J]. 承德医学院学报, 2019, 36(1): 11-15.

CHEN Xiao, ZHANG Yun-peng, DOU Zhi-jie, et al. RELATIONSHIPS BETWEEN APOLIPOPROTEIN B/A1, GLYCOSYLATED HEMOGLOBIN LEVEL AND VENOUS THROMBOLYSIS OUTCOME IN CEREBRAL INFARCTION PATIENTS[J]. Journal of Chengde Medical University, 2019, 36(1): 11-15.

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