侵袭性垂体瘤组织TNF-α与IL-12的表达及意义

承德医学院学报 ›› 2019, Vol. 36 ›› Issue (2): 94-97.

侵袭性垂体瘤组织TNF-α与IL-12的表达及意义

刘思洋, 吴建龙, 乔建勇^△

承德市中心医院,河北承德 067000

收稿日期:2018-10-19 出版日期:2019-04-10 发布日期:2021-11-18
通讯作者: △

EXPRESSION AND SIGNIFICANCE OF TNF-Α AND IL-12 IN INVASIVE PITUITARY ADENOMAS

LIU Si-yang, WU Jian-long, QIAO Jian-yong

Chengde Central Hospital, Hebei Chengde 067000, China

Received:2018-10-19 Online:2019-04-10 Published:2021-11-18

摘要/Abstract

摘要： 目的:研究侵袭性垂体瘤（invasive pituitary adenomas,IPA）组织中肿瘤坏死因子-α（tumor necrosis factor-α,TNF-α）和白细胞介素-12（interleukin,IL-12）的表达及临床意义。方法:采用免疫组织化学染色法（Max Vision二步法）检测40例IPA及40例非IPA组织中TNF-α和IL-12的表达情况。结果:IPA组织TNF-α的阳性表达率（65.0%）明显高于非IPA组织,IL-12的阳性表达率（32.5%）明显低于非IPA组织,组间比较差异具有统计学意义（P<0.05）。结论:TNF-α、IL-12可能在IPA的发生发展过程中具有重要作用。

关键词: 侵袭性垂体瘤（IPA）, 肿瘤坏死因子-α（TNF-α）, 白细胞介素-12（IL-12）, 免疫组织化学染色

Abstract: Objective: To study the expression and clinical significance of tumor necrosis factor-α (TNF-α) and interleukin -12 (IL-12) in invasive pituitary tumors (invasive pituitary adenomas, IPA). Methods: Immunohistochemical staining (Max Vision two-step method) was used to detect the expression of TNF-α and IL-12 in 40 cases of IPA and 40 cases of non-IPA tissues. Results: The positive expression rate of TNF-α in IPA (65.0%) was remarkably higher than non-IPA tissues, while the positive expression rate of IL-12 (32.5%) was remarkably lower (P<0.05). Conclusions: TNF-α and IL-12 may play important role in development of IPA.

Key words: Invasive pituitary adenomas (IPA), Tumor necrosis factor-α (TNF-α), Interleukin-12 (IL-12), Immunohistochemical staining

中图分类号:

R739.41

刘思洋, 吴建龙, 乔建勇. 侵袭性垂体瘤组织TNF-α与IL-12的表达及意义[J]. 承德医学院学报, 2019, 36(2): 94-97.

LIU Si-yang, WU Jian-long, QIAO Jian-yong. EXPRESSION AND SIGNIFICANCE OF TNF-Α AND IL-12 IN INVASIVE PITUITARY ADENOMAS[J]. Journal of Chengde Medical University, 2019, 36(2): 94-97.

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