关键词: 脑电双频指数（BIS）, 靶控输注, 丙泊酚, 老年患者, 骨折手术

Abstract: Objective: To explore the effects of closed-loop target-controlled infusion (TCI) of propofol based on bispectral index (BIS) in surgery of elderly fracture patients. Methods: 80 elderly fracture patients were randomly divided into group A and group B with 40 patients in each group. The patients in group A were given propofol with BIS-based closed-loop TCI target-controlled infusion, while the patients in group B were given propofol with constant-speed infusion. The perioperative indicators and the incidence of perioperative events, as well as BIS, heart rate (HR) and mean arterial pressure (MAP) at five time point (T₁ before anesthesia induction, T₂ endotracheal intubation, T₃ skin incision, T₄ 30 minutes after operation, T₅ at the end of operation) of patients in 2 groups were compared. Results: The propofol dosage, recovery time and the time of tracheal extubation of patients in group A were obviously lower than group B (P˂0.05). At time point T₂ to T₅, the BIS and MAP of patients in group A were obviously higher than group B (P˂0.05), the HR were obviously lower than group B (P˂0.05). The incidence rate of perioperative events of group A was obviously lower than group B (5.00% vs 20.00%, P˂0.05). Conclusions: BIS-based closed-loop TCI target-controlled infusion of propofol can reduce the stress level surgery of elderly fracture patients and the propofol dosage, and also can improve the safety of operation effectively.

Key words: Bispectral index (BIS), Target-controlled infusion （TCI）, Propofol, Elderly patients, Fracture surgery