网膜素-1、内脂素、谷氨酰转肽酶与2型糖尿病患者CIMT的相关性

摘要/Abstract

摘要： 目的探讨网膜素-1、内脂素、谷氨酰转肽酶与2型糖尿病患者颈动脉内膜中层厚度（CIMT）的相关性。方法 116例2型糖尿病患者根据CIMT分为增厚组（CIMT≥0.9mm）和非增厚组（CIMT<0.9mm）,检测两组患者血清网膜素-1、内脂素、谷氨酰转肽酶等相关指标。结果增厚组2型糖尿病患者CIMT、内脂素明显高于非增厚组（P<0.05）,网膜素-1明显低于非增厚组（P<0.05）;两组谷氨酰转肽酶比较差异无统计学意义（P>0.05）。Spearman相关分析显示,2型糖尿病患者CIMT与网膜素-1呈负相关关系（r=–0.726,P<0.05）,与内脂素呈正相关关系（r=0.919, P<0.05）。多因素Logistic回归分析显示,内脂素是2型糖尿病患者CIMT增厚的独立危险因素。结论网膜素-1、内脂素与2型糖尿病患者CIMT具有相关性,可作为早期判断颈动脉粥样硬化的血清学指标。

关键词: 2型糖尿病, 颈动脉内膜中层厚度, 网膜素-1, 内脂素, 谷氨酰转肽酶

Abstract: Objective To investigate the correlations between carotid intima media thickness (CIMT) in patients with type 2 diabetes mellitus and omentin-1, visfatin, glutamyltranspeptidase. Methods The 116 patients with type 2 diabetes mellitus were divided into thickening group (CIMT≥0.9mm) and non-thickening group (CIMT<0.9mm) according to the CIMT. The omentin-1, visfatin and glutamyltranspeptidase in serum of patients in 2 groups were measured. Results The CIMT and visfatin of patients in thickening group were significantly higher than those in non-thickening group (P<0.05), the omentin-1 were significantly lower (P<0.05). There was no significant difference in glutamyltranspeptidase between the two groups (P>0.05). Spearman correlation analysis showed that the CIMT of type 2 diabetic patients negatively correlated with omentin-1 (r =–0.726, P<0.05), but positively correlated with visfatin (r = 0.919, P<0.05). Multivariate logistic regression analysis showed that visfatin was the independent risk factor for CIMT thickening in type 2 diabetic patients. Conclusion Omentin-1 and visfatinare correlated with CIMTin patients with type 2 diabetesmellitus, which can be used as serological indexs for early diagnosis of carotid atherosclerosis.

Key words: type 2 diabetes mellitus, carotid intima media thickness, omentin-1, visfatin, glutamyltranspeptidase

中图分类号:

R587.1

王楠, 朱红涛, 刘晓燕. 网膜素-1、内脂素、谷氨酰转肽酶与2型糖尿病患者CIMT的相关性[J]. 承德医学院学报, 2020, 37(3): 198-200.

WANG Nan, ZHU Hong-tao, LIU Xiao-yan. The Correlations Between CIMT in Patients with Type 2 Diabetes Mellitus and Omentin-1, Visfatin and Glutamyl transpeptidase[J]. Journal of Chengde Medical University, 2020, 37(3): 198-200.

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