[1] Chen W, Zheng R, Baade PD, et al.Cancer statistics in China, 2015[J]. CA Cancer J Clin, 2016, 66(2):115-132. [2] 王雪华. 胃癌流行病学研究进展[J].饮食保健,2020,7(1):292-293. [3] Vinken M, De Kock J, Oliveira AG, et al.Modifications in connexin expression in liver development and cancer[J]. Cell Commun Adhes, 2012,19(3-4):55-62. [4] Wu JI, Wang LH.Emerging roles of gap junction proteins connexins in cancer metastasis, chemoresistance and clinical application[J]. J Biomed Sci, 2019, 26(1): 8. [5] Zhou HH, Zhao HB, Liu H, et al.Influence of carboplat-in onthe proliferation and apoptosis of ovarian cancer cellthrough mTOR/p70s6k signaling pathway[J]. J BUON, 2018,23(6):1732-1738. [6] 沈斌,韦卉,任茜,等.缝隙连接蛋白43与肿瘤关系的研究进展[J].医学综述,2017,23(20): 4001-4006. [7] Chasampalioti M, Green AR, Ellis IO, et al.Connexin 43 is an independent predictor of patient outcome in breast cancer patients[J]. Breast Cancer Res Treat, 2019,174(1): 93-102. [8] Torre LA, Bray F, Siegel RL, et al.Global cancer statistics, 2012[J]. CA Cancer J Clin, 2015, 65(2):87-108. [9] 姚鹏,杨灵,郭文君.Cox-2、Cx43的表达及Hp感染在胃腺癌发生发展的作用及相关性[J].现代肿瘤医学,2015,23(16): 2335-2340. [10] 潘理会,霍峰,李春辉.Cx43、Shh与P-Ezrin蛋白在胃癌组织中的表达及意义[J].中国老年学杂志,2018,38(15):3736-3739. [11] Yao P, Yang L, Guo WJ.The effect of cytooxygenase-2,connexin 43 proteins expression and H.pylori infection to the occurrence of gastric adenocarcinoma and its correlation analysis[J]. J Modern Oncology, 2015, 23(16): 2335-2340. [12] Amieva MR, Vogelmann R, Covacci A, et al. Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA[J]. Science, 2003,3 00(5624): 1430-1434. [13] 陶然,方平楚,叶少菁,等.幽门螺杆菌感染与胃上皮细胞间隙连接功能的体外研究[J].实用肿瘤杂志,2005,20(2): 118-120. [14] Beardslee MA, Lerner DL, Tadros PN, et al.Dephosphorylation and intracellular redistribution of ventricular connexin43 during electrical uncoupling induced by ischemia[J]. Circ Res, 2000, 87(8): 656-662. [15] Yamasaki H, Omori Y, Zaidan-Dagli ML, et al.Genetic and epigenetic changes of intercellular communication genes duri-ngmultistage carcinogenesis[J]. Cancer Detect Prev, 1999,23(4): 273-279. [16] Tang B, Peng ZH, Yu PW, et al.Expression and significance of Cx43 and E-cadherin in gastric cancer and metastatic lymph nodes[J]. Med Oncol, 2011, 28(2): 502-508. [17] Tang B, Peng ZH, Yu PW, et al.Aberrant Expression of Cx43 Is Associated with the Peritoneal Metastasis of Gastric Cancer and Cx43-Mediated Gap Junction Enhances Gastric Cancer Cell Diapedesis from Peritoneal Mesothelium[J]. PLoS One, 2013, 8(9): e74527. [18] 段佐平,廖荣波,杨显金,等.甲状腺癌组织中Skp2和Cx43的表达与患者临床病理特征的关系[J].中华普外科手术学杂志(电子版),2019,13(3): 266-269. [19] Liu X, Can K, Xu C, et al. GATA-3 augmentation downregulates Connexin43 in helicobacter pylori associated gastric carcinogenesis[J]. Cancer Biol Ther, 2015, 16(6): 987-996. [20] 张立伟,张爱东,谭淑娟,等.胃癌中Cx43与P-Ezrin表达的意义及相关性研究[J].重庆医学,2018,47(17):2353-2358. [21] Kim MS, Gloor GB, Bai D.The distribution and functional properties of Pelizaeus-Merzbacher- like disease-linked Cx47 mutations on Cx47/Cx47 homotypic and Cx47/Cx43 heterotypic gap junctions[J]. Biochem J, 2013, 452(2): 249-58. [22] Liu D, Zhou H, Wu J, et al.Infection by Cx43 adenovirus increa-sed chemotherapy sensitivity in human gastric cancer BGC-823 cells: Not involving in induction of cell apoptosis[J]. Gene, 2015,574(2): 217-224. [23] Xu Mei-Nian, Hu Wei-Lie, Ao Chun-Ping, et al.Recent Advances on The Roles of mTOR Signal Pathway in The Pathogenesis and Progression of Adrenal Tumors[J]. Progress in Biochemistry and Biophysics, 2016,43(3):209-218. [24] Bahrami F, Pourgholami MH, Mekkawy AH, et al.Monepantel induces autophagy in human ovarian cancer cells through disruption of the mTOR/p70S6K signalling pathway[J]. Am J Cancer Res, 2014, 4(5): 558-571. [25] 李程飞,王永春,石菲,等.回转模拟失重对人脐静脉内皮细胞LC3、p62、p53和磷酸化p70S6K表达的影响[J].航天医学与医学工程,2016,29(5):313-317. [26] van der Hage JA, van den Broek LJCM, Legrand C, et al. Overexpression of P70 S6 kinase protein is associated with increased risk of locoregional recurrence in node-negativepremenopausal early breast cancer patients[J]. Br J Cancer, 2004, 90(8):1543-1550. [27] 陈洪芳,卢清军,任鹏. mTOR/p70S6K在胃癌中的表达及其临床意义[J].中国实用医刊,2014,41(20):16-18. [28] 于观贞,潘军.ErbB2/Grb2/mTOR 通路在胃癌发生发展中的作用[J]. 临床肿瘤学杂志,2008,13(8):686-691. [29] Dou N, Yu S, Ye X, et al.Aberrant overexpression of ADAR1 promotes gastric cancer progression by activating mTOR/p70S6K signaling[J]. Oncotarget, 2016, 7(52): 86161-86173. [30] Conciatori F, Ciuffreda L, Bazzichetto C, et al.mTOR cross-talk in cancer and potential for combination therapy[J]. Cancers(Basel), 2018,10(1): E23. [31] Doi T, Muro K, Boku N, et al.Multicenter phase II study of everolimus inpatients with previously treated metastatic gastric cancer[J]. J Clin Oncol, 2010, 28(11): 1904-1910. [32] Takahari D.Second-line chemotherapy for patients with advanced gastriccancer[J]. Gastric Cancer, 2017, 20(3): 395-406. [33] Kim ST, Lee J, Park SH, et al.Prospective phase II trial of everolimus inPIK3CA amplification/ mutation and/or PTEN loss patients with advanced solid tumors refractory to standard therapy[J]. BMC Cancer, 2017, 17(1): 211. [34] Fan Q, Aksoy O,Wong RA, et al.A kinase inhibitor targeted to mTORC1 drives regression in glioblastoma[J]. Cancer Cell, 2017, 31: 424-435. [35] Hart S, Novotny-Diermayr V, Goh KC, et al.VS-5584, a novel and highlyselective PI3K/mTOR kinase inhibitor for the treatment of cancer[J]. Mol Cancer Ther, 2013, 12: 151-161. [36] 费洪荣,赵莹,王桂玲,等.PI3K/mTOR双重抑制剂PF-04691502诱导人胃癌SGC-7901细胞凋亡[J].中国病理生理杂志,2013,29(11):1962-1965. [37] Bhattacharya B, Akram M, Balasubramanian I, et al.Pharmacologic synergy between dual phosphoinositide-3-kinase and mammalian target of rapamycin inhibition and 5-fluorouracil in PIK3CA mutant gastric cancer cells[J]. Cancer Biol Ther, 2012, 13(1): 34-42. [38] Janku F, Tsimberidou AM, Garrido-Laguna I, et al.PIK3CA mutations in patients with advanced cancers treated with PI3K/AKT/mTORaxis inhibitors[J]. Mol Cancer Ther, 2011, 10(3): 558-565. [39] Zhang CH, Awasthi N, Schwarz MA, et al.The dual PI3K/mTOR inhibitor NVP-BEZ235 enhances nab-paclitaxel antitumor response in experimental gastric cancer[J]. Int J Oncol, 2013, 43(5): 1627-1635. |