[1] DeFronzo RA. Pathogenesis of type 2 diabetes mellitus[J]. Med Clin North Am, 2004, 88(4):787-835.
[2] Chan DC.Fusion and fission: interlinked processes critical for mitochondrial health[J]. Annu Rev Genet, 2012, 46(1):265-287.
[3] Sebastian D, Hernandez-Alvarez MI, Segales J, et al.Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis[J]. Proc Natl Acad Sci USA, 2012, 109(14):5523-5528.
[4] Zorzano A, Liesa M, Palacin M.Mitochondrial dynamics as a bridge between mitochondrial dysfunction and insulin resistance[J]. Arch Physiol Biochem, 2009, 115(1):1-12.
[5] Lowell BB, Shulman GI.Mitochondrial dysfunction and type 2 diabetes[J]. Science, 2005, 307(5708):384-387.
[6] Hotamisligil GS.Inflammation and endoplasmic reticulum stress in obesity and diabetes[J]. Int J Obes(Lond), 2009, 32(S7):S52-S54.
[7] Mazumder S, De R, Debsharma S, et al.Indomethacin impairs mitochondrial dynamics by activating the PKCζ-p38-Drp1 pathway and inducing apoptosis in gastric cancer and normal mucosal cells[J]. J Biol Chem, 2019, 294(20):8238-8258.
[8] Rodriguez-Nuevo A, Diaz-Ramos A, Noguera E, et al.Mitochondrial DNA and TLR9 drive muscle inflammation upon Opa1 deficiency[J]. EMBO J, 2018, 37(10):e96553.
[9] Pernas L, Scorrano L.Mito-morphosis: mitochondrial fusion,fission,and cristae remodeling as key mediators of cellularfunction[J]. Annu Rev Physiol, 2016, 78:505-531.
[10] Tilokani L, Nagashima S, Paupe V, et al.Mitochondrial dynamics: overview of molecular mechanisms[J]. Essays Biochem, 2018, 62(3):341-360.
[11] Youle RJ, van der Bliek AM. Mitochondrial fission, fusion, and stress[J]. Science, 2012, 337(6098): 1062-1065.
[12] Otera H, Mihara K.Molecular mechanisms and physiologic functions of mitochondrial dynamics[J]. J Biochem, 2011, 149(3):241-251.
[13] Yoon Y, Krueger EW, Oswald BJ, et al.The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamic-like protein DLP1[J]. Mol Cell Biol, 2003, 23(15): 5409-5420.
[14] Yu R, Jin SB, Lendahl U, et al.Human Fis1 regulates mitochondrial dynamics through inhibition of the fusion machinery[J]. EMBO J, 2019, 38(8):e99748.
[15] Loson OC, Song Z, Chen H, et al.Fis1, Mff, MiD49, and MiD51 mediate Drp1 recruitment in mitochondrial fission[J]. Mol Biol Cell, 2013, 24(5):659-667.
[16] Yu R, Liu T, Jin SB, et al.MIEF1/2 function as adaptors to recruit Drp1 to mitochondria and regulate the association of Drp1 with Mff[J]. Sci Rep, 2017, 7(1):880.
[17] Li D, Wang J, Jin Z, et al.Structural and evolutionary characteristics of dynamin-related GTPase OPA1[J]. Peer, 2019, 7:e7285.
[18] Reinhardt F, Schultz J, Waterstradt R, et al.Drp1 guarding of the mitochondrial network is importantfor glucose-stimulated insulin secretion in pancreatic beta cells[J]. Biochem Biophys Res Commun, 2016, 474(4):646-651
[19] Kabra UD, Pfuhlmann K, Migliorini A, et al.Direct substrate delivery into mitochondrial fission-deficient pancreatic islets rescues insulin secretion[J]. Diabetes, 2017, 66(5):1247-1257.
[20] Park KS, Wiederkehr A, Kirkpatrick C, et al.Selective actions of mitochondrial fission/fusion genes on metabolism-secretion coupling in insulin-releasing cells[J]. J Biol Chem, 2008, 283(48):33347-33356.
[21] Schultz J, Waterstradt R, Kantowski T, et al.Precise expression of fis1 is important for glucose responsiveness of beta cells[J]. J Endocrinol, 2016, 230(1):81-91.
[22] Twig G, Elorza A, Molina AJA, et al.Fission and selective fusion govern mitochondrial segregation and elimination by autophagy[J]. EMBO J, 2008, 27(2):433-446.
[23] Park KS, Wiederkehr A, Wollheim CB.Defective mitochondrial function and motility due to mitofusin 1 overexpression in insulin secreting cells[J]. Korean J Physiol Pharmacol, 2012, 16(1):71-77.
[24] Yoon Y, Galloway CA, Jhun BS, et al.Mitochondrial dynamics indiabetes[J]. Anti Oxid Redox Signal, 2011, 14(3):439-457.
[25] Jahani-Asl A, Cheung EC, Neuspiel M, et al.Mitofusin 2 protects cerebellar granule neurons against injury- induced cell death[J]. J Biol Chem, 2007, 282(33):23788-23798.
[26] Dai W, Jiang L.Dysregulated mitochondrial dynamics and metabolism in obesity, diabetes, and cancer[J]. Front Endocrinol(Lausanne), 2019, 10:570.
[27] Stiles L, Shirihai O.Mitochondrial dynamics and morphology in beta-cells[J]. Best Pract Res Clin Endocrinol Metab, 2012, 26(6):725-738.
[28] Park J, Choi H, Min JS, et al.Mitochondrial dynamics modulate the expression ofpro-inflammatory mediators in microglial cells[J]. J Neurochem, 2013, 127(2):221-232.
[29] Wang X, Jiang W, Yan Y, et al.RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway[J]. Nat Immunol, 2014, 15(12):1126-1133.
[30] Ding S, Xu S, Ma Y, et al.Modulatory mechanisms of the NLRP3 inflammasomes in diabetes[J]. Biomolecules, 2019, 9(12):850.
[31] Weiss-Sadan T, Maimoun D, Oelschlagel D.Cathepsins drive anti-inflammatory activity by regulating autophagy and mitochondrial dynamics in macrophage foam cells[J]. Cell Physiol Biochem, 2019, 53(3): 550-572.
[32] Yu T, Robotham JL, Yoon Y.Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology[J]. Proc Natl Acad Sci USA, 2006, 103(8):2653-2658.
[33] Gutierrez-Rodelo C, Roura-Guiberna A, Olivares-Reyes JA.Molecular Mechanisms of Insulin Resistance: An Update[J]. Gac Med Mex, 2017, 153(2):214-228.
[34] Geto Z, Molla MD, Challa F.Mitochondrial dynamic dysfunction as a main triggering factor for inflammation associated chronic non-communicable diseases[J]. J Inflamm Res, 2020, 13:97-107.
[35] Donath MY, Shoelson SE.Type 2 diabetes as an inflammatory disease[J]. Nat Rev Immunol, 2011, 11(2):98-107.
[36] Rehman K, Akash MSH.Nutrition and diabetes mellitus: How are they interlinked[J]. Crit Rev Eukaryot Gene Expr, 2016, 26(4):317-332.
[37] Donath MY, Boni-Schnetzler M, Ellingsgaard H, et al.Islet inflammation impairs the pancreatic beta-cell in type 2 diabetes[J]. Physiology (Bethesda), 2009, 24:325-331.
[38] Tilg H, Moschen AR.Inflammatory mechanisms in the regulation of insulin resistance[J]. Mol Med, 2008, 14(3-4):222-231.
[39] Hirosumi J, Tuncman G, Chang L, et al.A central role for JNK in obesity and insulin resistance[J]. Nature, 2002, 420(6913):333-336.
[40] Cai DS, Yuan MS, Frantz DF, et al.Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB[J]. Nat Med, 2005, 11(2):183-190.
[41] Yu TZ, Jhun BS, Yoon Y.High-glucose stimulation increases reactive oxygen species production through the calcium and mitogen-activated protein kinase-mediated activation of mitochondrial fission[J]. Antioxid Redox Signal, 2011, 14(3):425-437.
[42] Yu TZ, Sheu SS, Robotham JL, et al.Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species[J]. Cardiovasc Res, 2008, 79(2):341-351.
[43] 徐佳,关越琪,于芷懿,等. 基因敲除技术及其在研究线粒体动力学与胰岛素抵抗关系中的应用进展[J].生物工程学报,2019,35(8):1382-1390.
[44] Jheng HF, Tsai PJ, Guo SM, et al.Mitochondrial fission contributes to mitochondrial dysfunction and insulin resistance in skeletal muscle[J]. Mol Cell Biol, 2012, 32(2):309-319. |
