自拟脾胃安方治疗脾虚气滞型餐后窘迫综合征的临床观察

摘要/Abstract

摘要： 目的对脾虚气滞型餐后窘迫综合征患者采取自拟脾胃安方治疗,并观察其临床疗效。方法选取2018年1月~2021年1月收治的脾虚气滞型餐后窘迫综合征患者,临床研究部分采用随机、双盲、安慰剂的设计方法,将符合纳入标准的96例患者随机分入治疗组（64例）和安慰组（32例）,分别给予自拟脾胃安方及安慰剂,4w后观察效果、评价治疗前后患者中医证候积分、餐后不适严重程度积分、血清Ghrelin水平变化。结果运用自拟脾胃安方进行治疗后,患者中医证候总积分、餐后不适程度积分、血清Ghrelin水平明显改善,优于安慰剂组(P<0.01或P<0.05);两组均无不良反应发生。结论自拟脾胃安方可有效治疗脾虚气滞型餐后窘迫综合征,改善脾胃功能。

关键词: 功能性消化不良, 餐后窘迫综合征, 脾虚气滞, 临床疗效

中图分类号:

R242

魏红. 自拟脾胃安方治疗脾虚气滞型餐后窘迫综合征的临床观察[J]. 承德医学院学报, 2022, 39(2): 132-136.

参考文献

[1] Ford AC, Mahadeva S, Carbone MF, et al.Functional dyspepsia[J]. Lancet, 2020, 396(10263): 1689-1702.
[2] Mounsey A, Barzin A, Rietz A.Functional Dyspepsia: Evaluation and Management[J]. Am Fam Physician, 2020, 101(2): 84-88.
[3] Talley NJ.Functional dyspepsia: new insights into pathogenesis and therapy[J]. Korean J Intern Med, 2016, 31(3): 444-456.
[4] Tack J, Masuy I, Van Den Houte K, et al. Drugs under development for the treatment of functional dyspepsia and related disorders[J]. Expert Opin Investig Drugs, 2019, 28(10): 871-889.
[5] Drossman DA.The functional gastrointestinal disorders and the Rome III process[J]. Gastroenterology, 2006, 130(5): 1377-1390.
[6] Tack J, Talley NJ, Camilleri M, et al.Functional gastroduodenal disorders[J]. Gastroenterology, 2006, 130(5): 1466-1479.
[7] Matsueda K, Hongo M, Tack J, et al.A placebo-controlled trial of acotiamide for meal-related symptoms of functional dyspepsia[J]. Gut, 2012, 61(6): 821-828.
[8] Jinyoung S, Tae-Hoon O, Joo-Yun K, et al.Efficacy and Safety of the Cudrania tricuspidata Extract on Functional Dyspepsia: A Randomized Double-Blind Placebo-Controlled Multicenter Study[J]. J Clin Med, 2021, 10(22): 5323.
[9] Jing H, Qian Y, Xin X.Clinical efficacy of Tiaoqi Jiangni decoction in the treatment of functional dyspepsia and its influence on life quality[J]. Am J Transl Res, 2021, 13(10): 11662-11670.
[10] Siriwardana RC, Niriella MA, Dassanayake AS, et al.Factors affecting post-embolization fever and liver failure after trans-arterial chemo-embolization in a cohort without background infective hepatitis-a prospective analysis[J]. BMC Gastroenterology, 2015, 4(15): 96.
[11] Shin A, Preidis GA, Shulman R, et al.The Gut Microbiome in Adult and Pediatric Functional Gastrointestinal Disorders[J]. Clin Gastroenterol Hepatol, 2019, 17(2): 256-274.
[12] Sayuk GS, Gyawali CP.Functional Dyspepsia: Diagnostic and Therapeutic Approaches[J]. Drugs, 2020, 80(13): 1319-1336.
[13] Duncanson KR, Talley NJ, Walker MM, et al.Food and functional dyspepsia: a systematic review[J]. J Hum Nutr Diet, 2018, 31(3): 390-407.
[14] Tack J, Camilleri M.New developments in the treatment of gastroparesis and functional dyspepsia[J]. Curr Opin Pharmacol, 2018, 43: 111-117.
[15] Christopher T, Gregory SS.The Brain-Gut-Microbiotal Axis: A framework for understanding functional GI illness and their therapeuticinterventions[J]. Eur J Intern Med, 2021, 84: 1-9.
[16] Lacy BE, Cangemi D, Vazquez-Roque M.Management of Chronic Abdominal Distension and Bloating[J]. Clin Gastroenterol Hepatol, 2021, 19(2): 219-231.
[17] Gregory SS.Editorial: Functional Dyspepsia Treatment: Trials and Tribulations of Targeted Strategies[J]. Am J Gastroenterol, 2017, 112(6): 910-912.
[18] 张声生,陈贞,许文君,等. 基于“寒、热、虚、实”二次辨证的565例功能性消化不良证候分布特点研究[J]. 中华中医药杂志,2008,23(9):833-835.
[19] Kissileff HR, Carretta JC, Geliebter A, et al.Cholecystokinin and stomach distension combine to reduce food intake in humans[J]. Am J Physiol Regul Integr Comp Physiol, 2003, 285(5): 992-998.
[20] MacIntosh CG, Morley JE,Wishart J, et al. Effect of exogenous cholecystokinin (CCK)-8 on food intake and plasma CCK, leptin, and insulin concentrations in older and young adults: evidence for increased CCK activity as a cause of the anorexia of aging[J]. J Clin Endocrinol Metab, 2001, 86(12): 5830-5837.
[21] Dornonville de la Cour C, Lindström E, Norlén P, et al. Ghrelin stimulates gastric emptying but is without effect on acid secretion and gastric endocrine cells[J]. Regul Pept, 2004, 120(1-3): 23-32.
[22] Peeters TL.Central and peripheral mechanisms by which ghrelin regulates gut motility[J]. J Physiol Pharmacol, 2003, 54(4): 95-103.
[23] 周军峰,刘水章. 香砂六君子汤治疗功能性消化不良78例[J]. 临床医药文献杂志,2014,1(12):2107-2108.
[24] 赵鹏,黄穗平,尚文璠. 健脾理气方治疗脾虚气滞型痞满病的临床研究[J]. 中国中医药现代远程教育,2013,11(1):1-2.
[25] 孙靖若. 香砂六君子汤加味治疗脾虚气滞型功能性消化不良50例[J]. 中国民族民间医药,2017,26(6):94-96.
[26] 涂志红. 自拟补脾益胃散治疗脾虚气滞型功能性消化不良[J]. 光明中医, 2013,28(11):2287-2288.
[27] 冯溢君. 脾虚气滞型功能性消化不良应用香砂六君子汤加味效果临床观察[J]. 中医临床研究,2020,12(35):40-43.
[28] 刘迎霞. 中医治疗脾虚气滞型功能性消化不良的临床观察[J]. 江西中医药,2020,51(452):44-46.
[29] 赵永超,周云飞. 脾虚气滞型功能性消化不良应用香砂六君子汤加味效果分析[J]. 实用中西医结合临床,2019,19(9):15-17.
[30] Jing L, Feng L, Xu-Dong T, et al.XiangshaLiujunzi decoction alleviates the symptoms of functional dyspepsia by regulating brain-gut axis and production of neuropeptides[J]. BMC Complement Altern Med, 2015,15(27): 387.