关键词: 脑膜瘤, 术后, 复发, 危险因素

Abstract: Objective To explore the risk factors of postoperative recurrence of benign meningioma. Methods A total of 241 cases of postoperative patients with benign meningiomas in Affiliated Hospital of Chengde Medical University were selected as the research object (using a retrospective method), the selection time is from January 2018 to March 2021, and all the patients' clinical basic data were sorted and analyzed. According to whether the recurrence within 1 year after surgery, patients were divided into no recurrence group (212 cases) and recurrence group (29 cases). Single factor analysis was applied to analyze the clinical data of the two groups, and multivariate Logistic regression analysis was applied to analyze the statistically significant factors and screen out the independent risk factors for postoperative recurrence of benign meningioma. Results Among the postoperative patients with benign meningiomas, the proportion of patients with tumor site (cerebral falx or venous sinus), maximum tumor diameter>5cm, partial tumor resection, unclear tumor boundary, histopathological endothelial type/fibroblast and Ki-67 expression≥8% in the recurrence group was higher than that in the non-recurrence group, and the difference was statistically significant (P<0.05). There was no statistically significant difference in gender, age, tumor shape, peritumoral edema, meningeal tail sign, FASN expression and PCNA expression between the two groups (P>0.05). Tumor location (cerebral falx or venous sinus), tumor maximum diameter>5cm, partial tumor resection, unclear tumor boundary, histopathological endothelial type/fibroblast and Ki-67 expression≥8% were all risk factors for recurrence of benign meningioma postoperative patients. The differences were statistically significant (P<0.05). Conclusion Tumor site (cerebral falx or venous sinus), maximum tumor diameter>5cm, partial tumor resection, unclear tumor boundary, histopathological endothelial type/fibroblast and Ki-67 expression≥8% are all risk factors for recurrence of patients with benign meningioma after operation. Therefore, corresponding clinical measures can be taken to prevent and treat patients with benign meningioma after operation to improve their prognosis and reduce recurrence rate.

Key words: meningioma, postoperatively, relapse, risk factor