NF-κB和EGFR在胃癌组织中的表达及临床病理意义

承德医学院学报 ›› 2023, Vol. 40 ›› Issue (3): 199-202.

NF-κB和EGFR在胃癌组织中的表达及临床病理意义

王爱民¹, 焦海涛², 李常洲¹, 尹静一¹, 吴建龙¹, 张诗彤¹

1.承德市中心医院消化内科,河北承德 067000;
2.承德医学院,河北承德 067000

收稿日期:2022-10-25 出版日期:2023-06-10 发布日期:2023-09-15
基金资助:
承德市科技计划项目(201601A018)

Expression and Clinicopathological Significance of NF-κB and EGFR in Human Gastric Cancer

WANG Ai-min¹, JIAO Hai-tao², LI Chang-zhou¹, YIN Jing-yi¹, WU Jian-long¹, ZHANG Shi-tong¹

1. Gastroenterology Department, Chengde Central Hospital, Chengde, Hebei, 067000, China;
2. Chengde Medical University, Hebei, 067000, China

Received:2022-10-25 Online:2023-06-10 Published:2023-09-15

摘要/Abstract

摘要： 目的探讨核因子-κB（NF-κB）和表皮生长因子受体（EGFR）在胃癌组织中的表达及其临床病理意义。方法采用免疫组织化学方法（SP法）对比分析106例胃癌组织和相应的正常胃黏膜组织中NF-κB、EGFR的表达情况,研究二者在胃癌中表达的相关性,探讨其与临床病理特征的关系。结果 NF-κB蛋白在胃癌组织阳性表达率为67.9%,明显高于相应正常胃黏膜组织（5.9%,P<0.05）。胃癌组织和正常黏膜组织EGFR的阳性表达率分别为65.1%和2.9%,胃癌组织EGFR表达显著高于正常胃黏膜组织（P<0.05）。胃癌组织中NF-κB的表达与EGFR的表达呈显著正相关（r=0.202,P=0.034）。NF-κB与EGFR在胃癌组织中的高表达与肿瘤浸润深度、淋巴结转移、临床分期有相关性。结论胃癌组织中NF-κB和EGFR的高表达与癌组织进展有关,且二者表达呈正相关,提示二者在胃癌的发生及发展过程中具有协同作用。

关键词: 胃癌, 核因子-κB, 表皮生长因子受体, 表达

Abstract: Objective To investigate the expression and clinicopathological significance of nuclear factor-κB (NF-κB) and epidermal growth factor receptor (EGFR) in gastric cancer tissues. Methods The expressions of NF-κB and EGFR in 106 gastric cancer patients and corresponding normal gastric mucosa tissues were compared and analyzed by immunohistochemical method. The correlation between the expression of NF-κB and EGFR in gastric cancer was analyzed, and investigate its relationship with clinical pathology characteristic. Results The results showed that the positive expression rate of NF-κB protein in gastric cancer was 67.9%, which was significantly higher than that of the corresponding normal gastric mucosa tissue (5.9%, P<0.05). The positive rates of EGFR expression in gastric cancer tissue and normal mucosal tissue were 65.1% and 2.9%, respectively. The expression of EGFR in gastric cancer tissue was significantly higher than that in normal gastric mucosa tissue (P<0.05). The expression of NF-κB in gastric cancer tissue was significantly positively correlated with the expression of EGFR (r=0.202, P=0.034). The high expression of NF-κB and EGFR in gastric cancer tissues is correlated with the depth of tumor invasion, lymph node metastasis, and clinical stage. Conclusion The high expression of NF-κB and EGFR in gastric cancer tissues was associated with cancer progression, and their expression was positively correlated, suggesting synergistic effect of NF-κB and EGFR in the development and progression of gastric cancer.

Key words: gastric cancer, NF-κB, EGFR, expression

中图分类号:

R735.2

王爱民, 焦海涛, 李常洲, 尹静一, 吴建龙, 张诗彤. NF-κB和EGFR在胃癌组织中的表达及临床病理意义[J]. 承德医学院学报, 2023, 40(3): 199-202.

WANG Ai-min, JIAO Hai-tao, LI Chang-zhou, YIN Jing-yi, WU Jian-long, ZHANG Shi-tong. Expression and Clinicopathological Significance of NF-κB and EGFR in Human Gastric Cancer[J]. Journal of Chengde Medical University, 2023, 40(3): 199-202.

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