血清Betatrophin对2型糖尿病合并代谢相关脂肪性肝病预测价值的研究

摘要/Abstract

摘要： 目的观察Betatrophin水平在2型糖尿病合并代谢相关脂肪性肝病患者体内的变化,探讨其对疾病的预测价值。方法选取2021年1月~2021年11月在蚌埠医学院第二附属医院内分泌科住院的T2DM患者58例为病例组,根据是否合并代谢相关脂肪性肝病（MAFLD）将患者分为T2DM合并MAFLD组、单纯T2DM组,选取同期体检健康者为正常对照组。比较一般资料、血清Betatrophin、血糖、血脂等指标,分析Betatrophin与2型糖尿病合并代谢相关脂肪性肝病相关性。结果病例组与对照组相比,BMI、ALT、FPG、HOMA-IR、HbA1c、TG、LDL-C、HDL-C、Betatrophin存在差异,有统计学意义（P<0.05）。T2DM合并MAFLD组与单纯T2DM组比较,BMI、HOMA-IR、HbA1c、TG、Betatrophin指标比较差异均有统计学意义（P<0.05）。相关性分析发现,Betatrophin与TG呈正相关。多因素分析发现Betatrophin与TG是2型糖尿病患者合并代谢相关脂肪性肝病的独立影响因素（P<0.05）。结论 Betatrophin 水平在T2DM 合并MAFLD患者血清显著升高,促进疾病的发生和发展,对MAFLD有预测价值。

关键词: 代谢相关脂肪性肝病, 2型糖尿病, 血管生成素样蛋白8

Abstract: Objective To observe the changes of Betatrophin levels in type 2 diabetes mellitus combined with metabolism-related fatty liver diseases, and explore its predictive value for the disease. Methods A total of 58 patients with T2DM were admitted to the Department of Endocrinology and Metabolism in The Second Affiliated Hospital of Bengbu Medical College from January 2021 to November 2021 were selected as the case group. According to whether they had combined metabolic related fatty liver disease, patients were divided into T2DM with MAFLD group and T2DM alone group. Healthy subjects were selected as control group. We compared the general data, serum Betatrophin, blood glucose and lipid profiles, and analyzed the association between Betatrophin and type 2 diabetes mellitus with metabolic related fatty liver disease. Results There were significant differences in BMI, ALT, FPG, HOMA-IR, HbA1c, TG, LDL-C, HDL-C, Betatrophin between case group and control group (P<0.05). There were significant differences in BMI, HOMA-IR, HbA1c, TG and Betatrophin between T2DM with MAFLD group and T2DM alone group (P<0.05). Correlation analysis found that Betatrophin was positively correlated with TG. Multivariate analysis identified Betatrophin with TG as an independent risk factor for combined metabolic related fatty liver disease in patients with type 2 diabetes (P<0.05). Conclusion Betatrophin levels are significantly increased in the serum of T2DM patients with MAFLD, which promotes disease initiation and progression, and has predictive value for MAFLD.

Key words: metabolic-related fatty liver diseases, type 2 diabetes, Betatrophin

中图分类号:

R587.1

李娟, 徐家新, 王春, 王艳秋, 周路路. 血清Betatrophin对2型糖尿病合并代谢相关脂肪性肝病预测价值的研究[J]. 承德医学院学报, 2023, 40(6): 467-471.

LI Juan, XU Jia-xin, WANG Chun, WANG Yan-qiu, ZHOU Lu-lu. Predictive Value of Serum Betatrophin in Type 2 Diabetes Mellitus with Metabolic Related Fatty Liver Disease[J]. Journal of Chengde Medical University, 2023, 40(6): 467-471.

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