关键词: 多发性骨髓瘤, 血清sIL-2R表达情况, 预后关系

Abstract: Objective To explore the relationship between serum sIL-2R expression and patient prognosis in patients with multiple myeloma. Methods The 72 MM patients admitted from March 2018 to July 2020 were selected as the study object, and 72 MM patients were divided into survival group and death group according to the prognosis. The risk factors of death of MM patients were analyzed, the optimal cutoff of serum sIL-2R at the time of death, and the relationship between sIL-2R expression level and patient prognosis was evaluated. Results After 3 years of follow-up, 45 of 72 MM patients survived and 27 died, the mortality rate was 37.50% and the survival rate was 62.50%. The proportion of MM stage III was higher than the surviving group, and β₂-microglobulin level (β₂-MG), serum calcium (Ca) level, sIL-2R level and light chain ratio (K/λ) were higher than the surviving group, showing a statistically significant difference (P<0.05). Logistic Multivariate regression analysis, the results showed that MM stage, β₂-MG, Ca, sIL-2R level, and K/λ values were all risk factors for death in MM patients (P<0.05). The ROC curve showed that the optimal cut-off value of MM patients was 328.50, the area under the curve was 0.903, the sensitivity was 86.75%, the specificity was 88.75%, and 95% CI (1.27~3.01), suggesting that serum sIL-2R levels can be used to predict the prognosis of MM patients. Conclusion The sIL-2R level has an important predictive value for the prognosis of MM patients. MM stage, β₂-MG, Ca level and K / λ value are all risk factors for MM..

Key words: multiple myeloma, serum sIL-2R expression, prognostic relationship