血清ADPN、FKN、Gremlin在糖尿病肾病患者中的表达及与患者肾功能的相关性

摘要/Abstract

摘要： 目的探讨血清脂联素（ADPN）、不规则趋化因子（FKN）、Gremlin在糖尿病肾病（DN）患者中的表达及与患者肾功能的相关性。方法回顾性选取2020年6月~2022年6月河南科技大学第一附属医院收治的DN患者100例为观察组,另选取同期单纯糖尿病（DM）患者100例为对照组。比较2组血清ADPN、FKN、Gremlin水平,比较2组肾功能指标[血胱抑素C（CysC）、血肌酐（SCr）、尿蛋白排泄率（UAER）]水平,分析血清各指标水平与肾功能指标的相关性,ROC分析血清各指标对DN的诊断价值。结果观察组血清ADPN、FKN、Gremlin、CysC、SCr、UAER水平均高于对照组（P<0.05）;血清ADPN、FKN、Gremlin水平与肾功能指标CysC、SCr、UAER水平均呈正相关,且血清各指标水平联合诊断DN的AUC为0.885,最佳诊断敏感度、特异度分别为90.00%、85.00%,约登指数为0.750。结论 ADPN、FKN、Gremlin在DN患者血清中表达上调,各指标水平与肾功能指标水平呈正相关,联合检测对DN具有一定诊断价值,可作为临床诊断DN、评估肾功能的有效指标。

关键词: 脂联素, 不规则趋化因子, Gremlin, 糖尿病肾病, 肾功能

Abstract: Objective To investigate the expression of serum adiponectin (ADPN), irregular chemokine (FKN) and Gremlin in diabetic nephropathy (DN) patients and their correlation with renal function. Methods One hundred cases of DN patients admitted to First Affiliated Hospital of Henan University of Science and Technology from June 2020 to June 2022 were retrospectively selected as the observation group, and another 100 cases of simple diabetes mellitus (DM) patients in the same period were selected as the control group. The serum levels of ADPN, FKN and Gremlin were compared between the two groups, and the renal function indexes [cystatin C (CysC), creatinine (SCr) and urinary protein excretion rate (UAER)] were compared between the two groups. The correlation between serum indexes and renal function indexes was analyzed, and the diagnostic value of serum indexes in DN was analyzed by ROC. Results Serum levels of ADPN, FKN, Gremlin, CysC, SCr and UAER in observation group were higher than those in control group (P < 0.05). Serum levels of ADPN, FKN and Gremlin were positively correlated with renal function indexes CysC, SCr and UAER, and the AUC of all serum indexes in combined diagnosis of DN was 0.885, the best diagnostic sensitivity and specificity were 90.00% and 85.00%, respectively, and the Yoden index was 0.750. Conclusion ADPN, FKN and Gremlin are up-regulated in the serum of patients with DN, and the levels of each indicator are positively correlated with the levels of renal function indicators. Combined detection has certain diagnostic value for DN, and can be used as an effective indicator for clinical diagnosis of DN and evaluation of renal function.

Key words: adiponectin, irregular chemokines, gremlin, diabetic nephropathy, renal function

中图分类号:

R587.2

王路路. 血清ADPN、FKN、Gremlin在糖尿病肾病患者中的表达及与患者肾功能的相关性[J]. 承德医学院学报, 2024, 41(4): 289-292.

WANG Lu-lu. Expression of Serum ADPN, FKN and Gremlin in Diabetic Nephropathy Patients and Correlation with Renal Function[J]. Journal of Chengde Medical University, 2024, 41(4): 289-292.

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