糖尿病脑病发病机制的研究进展

承德医学院学报 ›› 2024, Vol. 41 ›› Issue (5): 417-421.

糖尿病脑病发病机制的研究进展

杨世瑜¹, 肖雨¹, 高思齐¹, 李继安², 邱昌龙², 储金秀^1,*

1.华北理工大学基础医学院/河北省慢性疾病基础医学重点实验室,河北唐山 063210;
2.华北理工大学中医学院/河北省中西医结合防治糖尿病及其并发症重点实验室

收稿日期:2023-12-07 出版日期:2024-10-10 发布日期:2024-10-28
通讯作者: *
基金资助:
河北省自然科学基金中医药联合基金重点项目（H2023209038）; 科技部对发展中国家科技援助项目（KY201904005）; 河北省高等学校科学技术研究项目（ZD2022141）

Received:2023-12-07 Online:2024-10-10 Published:2024-10-28

摘要/Abstract

关键词: 糖尿病脑病, 认知功能障碍, 胰岛素抵抗, 研究进展

中图分类号:

R587.1

杨世瑜, 肖雨, 高思齐, 李继安, 邱昌龙, 储金秀. 糖尿病脑病发病机制的研究进展[J]. 承德医学院学报, 2024, 41(5): 417-421.

导出引用管理器 EndNote|Ris|BibTeX

链接本文: http://tougao.cdmc.edu.cn:8088/CN/

http://tougao.cdmc.edu.cn:8088/CN/Y2024/V41/I5/417

[1] Chen YJ, Tang ZZ, Du L, et al.A novel compound AB-38b improves diabetes-associated cognitive decline in mice via activation of Nrf2/ARE pathway[J]. Brain Research Bulletin, 2019, 150: 160-167.
[2] Liu Y, Li M, Zhang Z, et al.Role of microglia-neuron interactions in diabetic encephalopathy[J]. Ageing Research Reviews, 2018, 42: 28-39.
[3] 刘申贝,古小云,钟志江,等. KKAy糖尿病脑病模型的探索及相关机制研究[J]. 中药药理与临床,2020,36(1):210-218.
[4] Kim B, Feldman EL.Insulin resistance in the nervous system[J]. Trends in Endocrinology Metabolism, 2012, 23(3): 133-141.
[5] Matulewicz N, Karczewska-Kupczewska M.Insulin resistance and chronic inflammation[J]. Advances in Hygiene and Experimental Medicine, 2016, 70: 1245-1258.
[6] Chen R, Shi J, Yin Q, et al.Morphological and pathological characteristics of brain in diabetic encephalopathy[J]. Journal of Alzheimer's Disease, 2018, 65(1): 15-28.
[7] Gokulakrishnan K, Mohanavalli KT, Monickaraj F, et al.Subclinical inflammation/oxidation as revealed by altered gene expression profiles in subjects with impaired glucose tolerance and type 2 diabetes patients[J]. Molecular and Cellular Biochemistry, 2009, 324: 173-181.
[8] 徐敏,杨红英. 氧化应激与糖尿病脑病[J]. 国际检验医学杂志,2008,29(8):2.
[9] Powers ET, Morimoto RI, Dillin A, et al.Biological and chemical approaches to diseases of proteostasis deficiency[J]. Annual Review of Biochemistry, 2009, 78: 959-991.
[10] 师思,王晓良. 星形胶质细胞在糖尿病脑病中的变化及作用[J]. 国际药学研究杂志,2016,43(1): 6.
[11] Vargas R, Rincón J, Pedreañez A, et al.Role of angiotensin II in the brain inflammatory events during experimental diabetes in rats[J]. Brain Research, 2012, 1453(1): 64-76.
[12] Ye X, Shen T, Hu J, et al.Purinergic 2X7 receptor/NLRP3 pathway triggers neuronal apoptosis after ischemic stroke in the mouse[J]. Experimental Neurology, 2017, 292: 46-55.
[13] Hang CH, Shi JX, Tian J, et al.Effect of systemic LPS injection on cortical NF-κB activity and inflammatory response following traumatic brain injury in rats[J]. Brain Research, 2004, 1026(1): 23-32.
[14] Muranyi M, Fujioka M, He Q, et al.Diabetes activates cell death pathway after transient focal cerebral ischemia[J]. Diabetes, 2003, 52(2): 481-486.
[15] Tsukuda K, Mogi M, Li JM, et al.Diabetes-associated cognitive impairment is improved by a calcium channel blocker, nifedipine[J]. Hypertension, 2008, 51(2): 528-533.
[16] Ly H, Despa F.Diabetes-related amylin dyshomeostasis: a contributing factor to cerebrovascular pathology and dementia[J]. Journal of Lipid and Atherosclerosis, 2019, 8(2): 144-151.
[17] Cantley J.The control of insulin secretion by adipokines: current evidence for adipocyte-beta cell endocrine signalling in metabolic homeostasis[J]. Mammalian Genome, 2014, 25(9-10): 442-454.
[18] Leal MC, Fernandez GA, Morelli L, et al.Cerebral proteolysis of amiloid-b peptide: relevance of insulin-degrading enzyme in Alzheimer's disease[J]. Medicina, 2009, 69(4): 466-472.
[19] Dey A, Hao S, Wosiski-Kuhn M, et al.Glucocorticoid-mediated activation of GSK3β promotes tau phosphorylation and impairs memory in type 2 diabetes[J]. Neurobiology Aging, 2017, 57: 75-83.
[20] Chen Q, Mo R, Wu N, et al.Berberine ameliorates diabetes-associated cognitive decline through modulation of aberrant inflammation response and insulin signaling pathway in DM rats[J]. Frontiers in Pharmacology, 2017, 8: 334.
[21] Peng D, Pan X, Cui J, et al.Hyperphosphorylation of tau protein in hippocampus of central insulin-resistant rats is associated with cognitive impairment[J]. Cellular Physiology and Biochemistry, 2013, 32(5): 1417-1425.
[22] Vlassara H, Palace MR.Glycoxidation: the menace of diabetes and aging[J]. Mount Sinai Journal of Medicine New York, 2003, 70(4): 232.
[23] Luévano-Contreras C, Gómez-Ojeda A, Macías-Cervantes MH, et al.Dietary advanced glycation end products and cardiometabolic risk[J]. Current Diabetes Reports, 2017, 17: 1-11.
[24] Prasad YD, Sonia S, Balvinder S, et al.Advanced glycation end products: A review[J]. Sch Acad J Biosci, 2013, 45: 2185-2197.
[25] Liang W, Zhang D, Kang J, et al.Protective effects of rutin on liver injury in type 2 diabetic db/db mice[J]. Biomedicine Pharmacotherapy, 2018, 107: 721-728.
[26] Gan WJ, Gao CL, Zhang WQ, et al.Kuwanon G protects HT22 cells from advanced glycation end product-induced damage[J]. Experimental and Therapeutic Medicine, 2021, 21(5): 1-9.
[27] Saliu JA, Oboh G, Omojokun OS, et al.Effect of dietary supplementation of Padauk (Pterocarpus soyauxii) leaf on high fat diet/streptozotocin induced diabetes in rats’ brain and platelets[J]. Biomedicine Pharmacotherapy, 2016, 84: 1194-1201.
[28] Nieto-Estévez V, Defterali Ç, Vicario-Abejón C.IGF-I: A Key Growth Factor that Regulates Neurogenesis and Synaptogenesis from Embryonic to Adult Stages of the Brain[J]. Frontiers in Neuroscience, 2016, 10: 52.
[29] Jiang J, Chen Z, Liang B, et al.Insulin-like growth factor-1 and insulin-like growth factor binding protein 3 and risk of postoperative cognitive dysfunction[J]. Springerplus, 2015, 4(1): 1-7.
[30] 赵鹏举,刘洋,刘志海,等. 益肾解毒通络汤治疗糖尿病脑病肾虚瘀阻证的临床观察[J]. 河北中医,2023,45(4):578-582.
[31] 石晶晶. 当归芍药散及健脾利湿拆方对雌性糖尿病小鼠认知障碍改善作用的机制研究[D]. 广州: 广州中医药大学, 2021.
[32] 孙大伟,冯丽莎,吴晓翠,等. 基于Sirt1探讨糖尿病脑病"瘀毒阻络"中医病机及治法[J]. 中医学报,2019,34(8):4.

糖尿病脑病发病机制的研究进展

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献

相关文章 15

编辑推荐

Metrics

本文评价

[1]	赵雯, 赵杨, 赵宇阳, 刘赛璇, 申兴斌. STAT5在结直肠癌中的研究进展[J]. 承德医学院学报, 2024, 41(5): 421-425.
[2]	宋立雪, 董雅洁, 卢锴锋, 钱文茹, 巨名飞. 甘油三酯葡萄糖乘积指数对非糖尿病患者冠心病发病的预测价值[J]. 承德医学院学报, 2023, 40(3): 195-198.
[3]	高星, 吕英雷, 魏依兰, 张云鹏, 李静, 窦志杰. 糖尿病认知功能障碍机制研究进展[J]. 承德医学院学报, 2022, 39(2): 155-159.
[4]	祝盼盼, 商亚珍. MAPK信号通路介导细胞凋亡的研究进展[J]. 承德医学院学报, 2021, 38(3): 243-245.
[5]	徐陈, 韩杰. 上尿路结石微创治疗新进展[J]. 承德医学院学报, 2021, 38(2): 149-151.
[6]	邱颖, 汪家龙. 急性粒细胞性白血病治疗药物研究进展[J]. 承德医学院学报, 2020, 37(6): 516-520.
[7]	邢鑫, 黄发贵, 李建国. 急性危重肾衰竭患者经血液净化治疗的研究进展[J]. 承德医学院学报, 2020, 37(5): 419-422.
[8]	王欢欢, 杨圣. 腰椎管狭窄症微创治疗的研究进展[J]. 承德医学院学报, 2020, 37(2): 166-168.
[9]	王胜强. 肥胖型男性2型糖尿病患者性激素和骨钙素水平的变化及其与IR的相关性[J]. 承德医学院学报, 2020, 37(1): 25-27.
[10]	付亏杰, 刘旭东, 范飞, 孙丽楠, 刘云芳, 姜贵云. 虚拟现实技术对脑卒中恢复期患者认知功能的影响^*[J]. 承德医学院学报, 2019, 36(4): 303-305.
[11]	徐辉, 许长理. 不同途径前列腺穿刺活检的研究进展^*[J]. 承德医学院学报, 2018, 35(4): 330-333.
[12]	孙一婵, 李东哲, 王丹丹, 宋妤轩, 宋成军, 陈志宏. 2型糖尿病与消化系统恶性肿瘤的关系研究进展^*[J]. 承德医学院学报, 2018, 35(3): 239-241.
[13]	薛茹, 安文忠, 李青, 辛小林, 杨莹, 单伟颖. 国内大学生学习型组织创建的研究进展^*[J]. 承德医学院学报, 2018, 35(1): 64-66.
[14]	李东哲, 刘美晓, 宋成军, 陈志宏. PI3K/Akt信号通路及PTEN与糖尿病肾病研究进展[J]. 承德医学院学报, 2018, 35(1): 69-73.
[15]	王弥, 李卫, 郭亚春, 宋鸿儒. 薯蓣皂苷元抗肿瘤作用机制研究进展[J]. 承德医学院学报, 2017, 34(6): 511-513.