乳腺癌患者血清NR3C2、PGRMC1、CA153水平及临床意义

摘要/Abstract

摘要： 目的探讨乳腺癌（BC）患者血清核受体亚家族C组成员2（NR3C2）、孕激素受体膜组分1（PGRMC1）、糖类抗原153（CA153）水平对术后复发转移的预测价值。方法选取2021年1月—2023年1月于南阳市中心医院接受BC改良根治术的102例患者作为研究对象,依据术后1年是否发生复发转移,将其分为发生组38例、未发生组64例。采用ELISA法检测血清NR3C2、PGRMC1水平,免疫化学发光法检测血清CA153水平。ROC分析血清NR3C2、PGRMC1、CA153对术后复发转移的预测价值。结果发生组术后血清NR3C2水平低于未发生组,PGRMC1、CA153水平高于未发生组（P<0.05）;偏相关性分析显示,NR3C2与术后复发转移呈负相关,PGRMC1、CA153与术后复发转移呈正相关（P<0.05）;术后2个月血清NR3C2、PGRMC1、CA153单项及联合预测术后1年复发转移的AUC值分别为0.771、0.775、0.825、0.909,且联合预测的AUC值大于单项指标预测（P<0.05）。结论血清NR3C2、PGRMC1、CA153对BC患者术后复发转移具有一定预测价值,且联合检测可提高预测效能。

关键词: 乳腺癌, 核受体亚家族C组成员2, 孕激素受体膜组分1, 糖类抗原153

Abstract: Objective To explore the predictive value of serum levels of nuclear receptor subfamily C member 2 (NR3C2), progesterone receptor membrane component 1 (PGRMC1), and carbohydrate antigen 153 (CA153) in predicting postoperative recurrence and metastasis in breast cancer patients. Methods A retrospective study was conducted on 102 breast cancer patients who underwent modified radical mastectomy at Nanyang Central Hospitall from January 2021 to January 2023. Patients were divided into two groups based on whether they experienced recurrence or metastasis one year after surgery: the occurrence group (38 cases) and the non-occurrence group (64 cases). Serum levels of NR3C2 and PGRMC1 were detected using ELISA, and serum CA153 levels were detected using immunochemical luminescence. The predictive value of serum NR3C2, PGRMC1, and CA153 for postoperative recurrent metastasis was analyzed using ROC. Results The postoperative serum levels of NR3C2 in the occurrence group were lower than those in the non-occurrence group, while the levels of PGRMC1 and CA153 were higher (P<0.05). Partial correlation analysis revealed that NR3C2 was negatively correlated with postoperative recurrence and metastasis, whereas PGRMC1 and CA153 were positively correlated (P<0.05). The AUC values for predicting postoperative 1-year recurrence and metastasis using serum levels of NR3C2, PGRMC1, and CA153, either individually or in combination, were 0.771, 0.775, 0.825, and 0.909, respectively, 2 months post-surgery. Notably, the AUC value for combined prediction was higher than that for individual indicators (P<0.05). Conclusion Serum NR3C2, PGRMC1, and CA153 have certain predictive value for postoperative recurrence and metastasis in breast cancer patients, and combined detection can improve the predictive efficacy.

Key words: breast cancer, nuclear receptor subfamily C group member 2, progesterone receptor membrane component 1, carbohydrate antigen 153

中图分类号:

R737.9

段奇, 陈琛, 王征. 乳腺癌患者血清NR3C2、PGRMC1、CA153水平及临床意义[J]. 承德医学院学报, 2025, 42(6): 477-482.

Duan Qi, Chen Chen, Wang Zheng. Serum levels of NR3C2, PGRMC1, and CA153 in breast cancer patients and their clinical significance[J]. Journal of Chengde Medical University, 2025, 42(6): 477-482.

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链接本文: http://tougao.cdmc.edu.cn:8088/CN/

http://tougao.cdmc.edu.cn:8088/CN/Y2025/V42/I6/477

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