血清TK1、LMTK3、CA199水平在结直肠癌辅助化疗中的变化及对化疗效果的评估价值

摘要/Abstract

摘要： 目的探讨血清胸苷激酶1（TK1）、狐猴酪氨酸激酶3（LMTK3）、糖类抗原199（CA199）水平在结直肠癌（CRC）辅助化疗疗程中的变化及其对化疗效果的评估价值。方法回顾性选取2021年7月~2023年7月于商丘市立医院行手术治疗的80例CRC患者为研究对象,术后1个月均接受辅助化疗,根据3个周期后化疗效果,将患者分为化疗有效组（33例）、化疗无效组（47例）。比较2组化疗前、化疗1个周期后、化疗2个周期后血清TK1、LMTK3、CA199水平,分析血清各指标与化疗效果相关性,分析各指标联合检测对CRC患者化疗无效的评估价值。结果化疗无效组血清TK1、LMTK3、CA199水平高于化疗有效组,且随着治疗时间推进,血清TK1、LMTK3、CA199水平逐渐下降,差异有统计学意义（P<0.05）;化疗1个周期后、化疗2个周期后,血清TK1、LMTK3、CA199水平与化疗效果呈负相关,差异有统计学意义（P<0.05）;化疗2个周期后血清TK1、LMTK3、CA199水平联合预测CRC患者化疗无效的受试者工作特征（ROC）曲线下面积（AUC）高于各指标单独检测,差异有统计学意义（P<0.05）。结论血清TK1、LMTK3、CA199水平在CRC患者化疗疗程中均有明显变化,可为临床评估化疗效果提供有效参考。

关键词: TK1, LMTK3, CA199, 结直肠癌, 化疗

Abstract: Objective To investigate the changes in serum levels of thymidine kinase 1 (TK1), lemur tyrosine kinase 3 (LMTK3), and Carbohydrate antigen 199 (CA199) during adjuvant chemotherapy for colorectal cancer (CRC) and their value in evaluating the efficacy of chemotherapy. Methods Eighty CRC patients who underwent surgical treatment in Shangqiu Municipal Hospital from July 2021 to July 2023 were retrospectively selected for the study, and all of them received adjuvant chemotherapy 1 month after surgery, and according to the effect of chemotherapy after 3 cycles, the patients were classified into chemotherapy-effective group (33 cases) and chemotherapy-ineffective group (47 cases). The levels of serum TK1, LMTK3 and CA199 before chemotherapy, after one cycle of chemotherapy and after two cycles of chemotherapy were compared between the two groups. The correlation between serum indicators and chemotherapy effect was analyzed, and the evaluation value of combined detection of indicators for chemotherapy ineffectiveness in patients with CRC was analyzed. Results The levels of serum TK1, LMTK3, and CA199 in the chemotherapy-ineffective group were higher than those in the chemotherapy-effective group, and the levels of serum TK1, LMTK3, and CA199 gradually decreased with the progress of treatment, with statistically significant differences (P<0.05). After one cycle of chemotherapy and two cycles of chemotherapy, the levels of serum TK1, LMTK3, and CA199 were negatively correlated with the efficacy of chemotherapy, and the differences were statistically significant (P<0.05). After two cycles of chemotherapy, the area under the receiver operating characteristic (ROC) curve (AUC) of the combined prediction of serum TK1, LMTK3, and CA199 levels for predicting ineffective chemotherapy in CRC patients was higher than that of each individual indicator, and the difference was statistically significant (P<0.05). Conclusion The serum levels of TK1, LMTK3 and CA199 in patients with CRC have significant changes during the course of chemotherapy, which can provide an effective reference for clinical evaluation of chemotherapy effect.

Key words: TK1, LMTK3, CA199, Colorectal cancer, Chemotherapy

中图分类号:

R735.3

孟丽君, 罗执芬. 血清TK1、LMTK3、CA199水平在结直肠癌辅助化疗中的变化及对化疗效果的评估价值[J]. 承德医学院学报, 2025, 42(2): 106-109.

MENG Li-jun, LUO Zhi-fen. Changes in Serum TK1, LMTK3, and CA199 Levels during Adjuvant Chemotherapy for Colorectal Cancer and Their Value in Evaluating the Efficacy of Chemotherapy[J]. Journal of Chengde Medical University, 2025, 42(2): 106-109.

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链接本文: http://tougao.cdmc.edu.cn:8088/CN/

http://tougao.cdmc.edu.cn:8088/CN/Y2025/V42/I2/106

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