老年慢性心力衰竭患者血清Nexilin、Beclin-1、CTRP5水平的变化及临床意义

摘要/Abstract

摘要： 目的探究老年慢性心力衰竭（CHF）患者血清微管连接蛋白（Nexilin）、自噬效应蛋白（Beclin-1）、补体Clq/肿瘤坏死因子相关蛋白5（CTRP5）水平的变化及临床意义。方法选取南阳市康复医院2022年3月~2023年3月收治的老年CHF患者88例为观察组,按照纽约心脏病学会（NYHA）心功能分级将其分为Ⅱ级、Ⅲ级、Ⅳ级,根据治疗6个月后患者预后情况将其分为预后良好者、预后不良者,另选取同期健康体检者88名为对照组,对比2组、不同心功能分级、不同预后患者血清Nexilin、Beclin-1、CTRP5水平,分析血清Nexilin、Beclin-1、CTRP5水平与心功能分级的相关性,各指标联合检测对患者预后不良的预测价值。结果观察组血清Nexilin、Beclin-1、CTRP5水平明显高于对照组（P<0.05）;心功能Ⅳ级患者血清Nexilin、Beclin-1、CTRP5水平明显高于Ⅲ级、Ⅱ级患者,Ⅲ级患者高于Ⅱ级（P<0.05）;血清Nexilin、Beclin-1、CTRP5水平与心功能分级呈正相关（P<0.05）;与预后良好者相比,预后不良者血清Nexilin、Beclin-1、CTRP5水平更高（P<0.05）;血清Nexilin、Beclin-1、CTRP5水平联合预测预后不良曲线下面积（AUC）为0.846,约登指数为0.491,敏感度为72.22%,特异度为76.92%（P<0.05）。结论血清Nexilin、Beclin-1、CTRP5水平与老年CHF关系密切,可为临床预测老年CHF提供有效参考。

关键词: Nexilin, Beclin-1, CTRP5, 老年慢性心力衰竭, 预后

Abstract: Objective To explore the changes and clinical significance of serum levels of microtubule-associated protein (Nexilin), Recombinant human Beclin 1 protein (Beclin-1), Complement Clq/tumor necrosis factor related protein 5 (CTRP5) in elderly patients with chronic heart failure. Methods A total of 88 elderly patients with chronic heart failure admitted to Nanyang Rehabilitation Hospital from March 2022 to March 2023 were selected as the observation group, they were divided into grade II, III, and IV according to the New York Heart Association (NYHA) classification of cardiac function. According to the prognosis of the patients after 6 months of treatment, they were divided into good prognosis and poor prognosis groups. In addition, 88 healthy physical examination subjects in the same period were selected as the control group. The levels of serum Nexilin, Beclin-1, and CTRP5 were compared between the two groups, different cardiac function grades, and different prognosis patients. The correlation between serum Nexilin, Beclin-1, and CTRP5 levels and cardiac function grades was analyzed, and the predictive value of combined detection of various indicators for poor prognosis was analyzed. Results The levels of serum Nexilin, Beclin-1, and CTRP5 in the observation group were significantly higher than those in the control group (P<0.05); the levels of serum Nexilin, Beclin-1, and CTRP5 in patients with cardiac function grade IV were significantly higher than those in patients with cardiac function grade III and II, and the levels in patients with cardiac function grade III were higher than those in patients with cardiac function grade II (P<0.05); the levels of serum Nexilin, Beclin-1, and CTRP5 were positively correlated with the classification of cardiac function (P<0.05). Compared with patients with good prognosis, patients with poor prognosis had higher levels of serum Nexilin, Beclin-1, and CTRP5 (P<0.05). The area under the curve (AUC) of the combined prediction of poor prognosis using serum levels of Nexilin, Beclin-1, and CTRP5 was 0.846, with a Youden index of 0.491, a sensitivity of 72.22%, and a specificity of 76.92% (P<0.05). Conclusion The levels of serum Nexilin, Beclin-1, and CTRP5 are closely related to elderly chronic heart failure, which can provide effective reference for clinical prediction of elderly chronic heart failure.

Key words: Key Words: Nexilin, Beclin-1, CTRP5, Chronic heart failure in the elderly, Prognosis

中图分类号:

R541.6

王俊华, 路云霞. 老年慢性心力衰竭患者血清Nexilin、Beclin-1、CTRP5水平的变化及临床意义[J]. 承德医学院学报, 2025, 42(2): 110-113.

WANG Jun-hua, LU Yun-xia. Changes and Clinical Significance of Serum Levels of Nexilin, Beclin-1 and CTRP5 in Elderly Patients with Chronic Heart Failure[J]. Journal of Chengde Medical University, 2025, 42(2): 110-113.

导出引用管理器 EndNote|Ris|BibTeX

链接本文: http://tougao.cdmc.edu.cn:8088/CN/

http://tougao.cdmc.edu.cn:8088/CN/Y2025/V42/I2/110

参考文献

[1] 梁卫章,石建平,柴丽娜,等. 血清组织蛋白酶K、解聚蛋白样金属蛋白酶-7与慢性心力衰竭患者心室重构和预后的关系[J]. 检验医学,2023,38(10):919-925.
[2] 王巧容,张晓磊,王淑贤. 不同心功能分级慢性心力衰竭患者血清NT-porBNP、cTnⅠ及HCY、hs-CRP表达与临床意义观察[J]. 临床和实验医学杂志,2023,22(21):2265-2269.
[3] Popli P, Tang S, Chadchan SB, et al.Beclin-1-dependent autophagy, but not apoptosis, is critical for stem-cell-mediated endometrial programming and the establishment of pregnancy[J]. Dev Cell, 2023, 58(10): 885-897.
[4] Uçar İMB, Çalan M, Tatar E, et al.Correlation of serum C1q-tumour necrosis factor-related protein 5 levels with metabolic parameters and carotid intima-media thickness in newly diagnosed type 2 diabetes mellitus patients[J]. Hormones (Athens), 2020, 19(4): 559-564.
[5] 中华医学会心血管病学分会心力衰竭学组,中国医师协会心力衰竭专业委员会,中华心血管病杂志编辑委员会. 中国心力衰竭诊断和治疗指南2018[J]. 中华心血管病杂志,2018,46(10):760-789.
[6] 刘海燕,宋毓青,陈永福,等. 沙库巴曲缬沙坦对射血分数降低型慢性心力衰竭患者的临床疗效及对B型脑钠肽和C反应蛋白水平的影响[J]. 中国医药,2022,17(1):15-18.
[7] Johansson J, Frykholm C, Ericson K, et al.Loss of Nexilin function leads to a recessive lethal fetal cardiomyopathy characterized by cardiomegaly and endocardial fibroelastosis[J]. Am J Med Genet A, 2022, 188(6): 1676-1687.
[8] 赵亚珍,熊莹,邢晨. 依普利酮结合卡托普利对老年慢性心力衰竭患者心功能BNP及Nexilin的影响[J]. 安徽医学,2020,41(2):146-148.
[9] 王蔚蔚,程艳,刘博雷,等. 老年难治性心力衰竭患者连续性肾脏替代治疗的效果及对血清因子水平的影响[J]. 中国血液净化,2021,20(2):86-89,94.
[10] 马宗仑,汪凤兰,陈雪斌,等. 慢性心力衰竭患者血清Cys C、Beclin-1、sST2与心室重构的相关性分析[J]. 医学理论与实践,2023,36(18):3180-3182.
[11] 李星阳,陶志明,林琦. 射血分数保留的心力衰竭患者心功能分级与相关检验指标的关系[J]. 心脑血管病防治,2023,23(1):29-33.
[12] 刘超利,李桑柔,岳秀青,等. Hippo-YAP信号通路通过Beclin1调控自噬参与血管平滑肌细胞表型转换的机制研究[J]. 临床急诊杂志,2022,23(12):870-877.
[13] 杨宏秀,袁宝军,刘丽,等. 血清CTRP1、CTRP5和CTRP1/CTRP5水平与不稳定型心绞痛的关系[J]. 天津医药,2023,51(3):307-310.
[14] 孙媛媛,余其贵,谢军. 血清CTRP3、CTRP5、CTRP9水平与老年慢性心力衰竭的临床关系[J]. 中国老年学杂志,2021,41(17):3633-3636.
[15] 钱子冰,张琦,曾佩芸,等. 补体C1q/肿瘤坏死因子相关蛋白中CTRP3、CTRP5、CTRP9、CTRP13生物学研究进展[J]. 中国糖尿病杂志,2022,30(5):379-382.