血清NT-proBNP、sLOX-1、HDAC3水平联合检测对急性心肌梗死患者疾病转归的预测价值

摘要/Abstract

摘要： 目的探讨血清N末端脑利钠肽原（NT-proBNP）、可溶性凝集素样氧化型低密度脂蛋白受体-1（sLOX-1）、组蛋白去乙酰化酶3（HDAC3）水平联合检测对急性心肌梗死（AMI）患者疾病转归的预测价值。方法回顾性选取开封市第三人民医院2021年11月~2024年2月收治的AMI患者为研究对象（n=155）,根据患者疾病转归情况分为好转组（n=118）、恶化组（n=37）。对比2组入院时及术后6 h血清NT-proBNP、sLOX-1、HDAC3水平,并分析其相关性及预测价值,分析其不同水平患者发生疾病恶化的危险度。结果恶化组入院时、术后6 h血清NT-proBNP、sLOX-1、HDAC3显著高于好转组（P<0.05）;入院时、术后6 h血清NT-proBNP、sLOX-1、HDAC3水平均与患者疾病转归呈正相关（P<0.05）;入院时、术后6 h血清NT-proBNP、sLOX-1、HDAC3水平联合预测转归不良的AUC分别0.895、0.928,均高于各指标单独预测（P<0.05）;入院时、术后6 h时血清NT-proBNP、sLOX-1、HDAC3高水平患者发生预后不良的危险度是低水平4~10倍（P<0.05）。结论 AMI患者血清NT-proBNP、sLOX-1、HDAC3水平变化可作为临床介入治疗后评估疾病转归的有效预测因子,可辅助临床评估疾病转归情况。

关键词: NT-proBNP, sLOX-1, HDAC3, 急性心肌梗死

Abstract: Objective To investigate the predictive value of serum N-terminal brain natriuretic peptide (NT-proBNP), soluble lectin like oxidized low density lipoprotein receptor-1 (sLOX-1) and histone deacetylase 3 (HDAC3) levels combined in patients with acute myocardial infarction (AMI). Methods AMI patients admitted to the Third People's Hospital of Kaifeng City from November 2021 to February 2024 were retrospective selected as the research subjects (n=155), and divided into improvement group (n=118) and deterioration group (n=37) according to their disease outcomes. Serum levels of NT-proBNP, sLOX-1 and HDAC3 were compared between the two groups at admission and 6h after operation, and their correlation and predictive value were analyzed, and the risk of disease deterioration was analyzed in patients with different levels. Results Serum NT-proBNP, sLOX-1 and HDAC3 in the worsening group were significantly higher than those in the improving group at admission and 6h after operation (P<0.05). Serum NT-proBNP, sLOX-1 and HDAC3 levels at admission and 6h after surgery were positively correlated with the disease outcome of patients (P<0.05). The AUC of the combined prediction of serum NT-proBNP, sLOX-1 and HDAC3 levels at admission and 6h after surgery was 0.895 and 0.928, respectively, which were higher than those predicted by each index alone (P<0.05). The risk of poor prognosis in patients with high levels of serum NT-proBNP, sLOX-1 and HDAC3 at admission and 6h after surgery was 4 to 10 times that of patients with low levels (P<0.05). Conclusion The changes in serum levels of NT-proBNP, sLOX-1, and HDAC3 in AMI patients can serve as effective predictors for evaluating disease outcomes after clinical intervention, and can assist in the clinical assessment of disease outcome.

Key words: NT-proBNP, sLOX-1, HDAC3, Acute myocardial infarction

中图分类号:

R542.2

宗鸽, 李武艳, 彭照飞. 血清NT-proBNP、sLOX-1、HDAC3水平联合检测对急性心肌梗死患者疾病转归的预测价值[J]. 承德医学院学报, 2025, 42(3): 204-208.

ZONG Ge, LI Wu-yan, PENG Zhao-fei. Predictive Value of Combined Detection of Serum NT-proBNP, sLOX-1 and HDAC3 Levels in Patients with Acute Myocardial Infarction[J]. Journal of Chengde Medical University, 2025, 42(3): 204-208.

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链接本文: http://tougao.cdmc.edu.cn:8088/CN/

http://tougao.cdmc.edu.cn:8088/CN/Y2025/V42/I3/204

参考文献

[1] 陈焱,陈胜岳,韩元元,等. 中性粒细胞/淋巴细胞比值和血小板/淋巴细胞比值对急性心肌梗死患者住院死亡风险的联合预测价值[J]. 中国全科医学,2023,26(20):2482-2487.
[2] Milazzo V, Cosentino N, Genovese S, et al.Diabetes Mellitus and Acute Myocardial Infarction: Impact on Short and Long-Term Mortality[J]. Adv Exp Med Biol, 2021, 1307: 153-169.
[3] Kubota T, Komukai K, Miyanaga S, et al.Out-of-Hospital Cardiac Arrest Does Not Affect Post-Discharge Survival in Patients With Acute Myocardial Infarction[J]. Circ Rep, 2021, 3(4): 249-255.
[4] 方顺淼,葛兴利,李运田,等. 脂蛋白相关磷脂酶A2和心型脂肪酸结合蛋白诊断急性心肌梗死的价值及与预后的关系[J]. 中华老年心脑血管病杂志,2022,24(2):148-150.
[5] 钱锦,王峰岩. 老年急性心肌梗死患者PCI术后血清NT-proBNP水平的影响因素并分析其对近期预后的影响[J]. 中国临床药理学与治疗学,2023,28(6):658-665.
[6] 常向飞,冯龙,应媛媛. HB-EGF、HDAC3联合LP-PLA2检测对老年冠心病患者PCI治疗预后的评估作用[J]. 分子诊断与治疗杂志,2023,15(2):201-204.
[7] 何卫斌,段新杰,王耀辉. 不同类型冠心病病人血清sLOX-1表达与经皮冠状动脉介入术后支架内再狭窄的关系[J]. 中西医结合心脑血管病杂志,2021,19(17):2974-2977.
[8] Kraler S, Wenzl FA, Georgiopoulos G, et al.Soluble lectin-like oxidized low-density lipoprotein receptor-1 predicts premature death in acute coronary syndromes[J]. Eur Heart J, 2022, 43(19): 1849-1860.
[9] Thygesen K, Alpert JS, Jaffe AS, et al.Fourth Universal Definition of Myocardial Infarction (2018)[J]. J Am Coll Cardiol, 2018, 72(18): 2231-2264.
[10] 中华医学会心血管病学分会介入心脏病学组,中国医师协会心血管内科医师分会血栓防治专业委员会,中华心血管病杂志编辑委员会. 中国经皮冠状动脉介入治疗指南(2016)[J]. 中华心血管病杂志,2016,44(5):382-400.
[11] 王玮,张林叶,刘冉. 血清Hcy、Cys-C水平与急性心肌梗死患者冠脉病变程度及预后的关系研究[J]. 湖南师范大学学报(医学版),2022,19(1):206-210.
[12] 周灿富,梁军,杨保生. 急性心肌梗死合并心力衰竭患者血清PCT、BNP水平变化及其与心功能的相关性[J]. 海南医学,2023,34(1):10-13.
[13] 罗伶俐,赖绍斌,王树源. D-二聚体、NT-proBNP水平与经PCI治疗的急性心肌梗死患者近期临床预后的相关性分析[J]. 中国急救复苏与灾害医学杂志,2023,18(8):990-992,997.
[14] 梁家志,廖尚宇. Gensini评分联合NT-proBNP对急性心肌梗死患者PCI术后并发心力衰竭的预测价值分析[J]. 中国心血管病研究,2022,20(6):564-570.
[15] 何文凤,薛成,郑健康,等. 急性心肌梗死患者不同时间窗PCI临床疗效及血清PⅠCP、PⅢNP、sLOX-1、IL-17水平比较[J]. 山东医药,2022,62(29):47-50.
[16] 杨传高,陆卫红,张涛,等. 血清可溶性凝集素样氧化低密度脂蛋白受体-1水平对PCI围术期相关性心肌梗死的预测价值[J]. 医学临床研究,2017,34(6):1176-1178.
[17] Zhang J, Liu XY, Chen J, et al.HDAC3-Mediated Repression of LncRNA-LET Regulates Gastric Cancer Cell Growth Proliferation, Invasion, Migration, and Apoptosis via MiR-548k[J]. J Environ Pathol Toxicol Oncol, 2021, 40(4): 21-32.
[18] 郝静宇,王金萍,管斌斌,等. 血清组蛋白去乙酰化酶3和热休克蛋白90水平与急性心肌梗死患者心室重构的相关性及预后评估价值[J]. 中国心血管病研究,2023,21(9):853-857.