关键词: 噻托溴铵, COPD, 肺功能, 炎性因子

Abstract: Objective To analyze the effect of tiotropium bromide on patients with chronic obstructive pulmonary disease (COPD) and the influence on peripheral blood EOS, IL-25 and IL-35. Methods A total of 186 patients with chronic obstructive pulmonary disease admitted from January 2018 to December 2019 were randomly divided into observation group and control group (93 patients each). On the basis of routine treatment were given to the patients in 2 groups, the control group was given salbutamol sulfate inhalation, while the observation group was given tiotropium bromide inhalation. Clinical symptoms, lung function test results and adverse reactions of the two groups were recorded, and EOS and IL-25, IL-35 were detected by Automatic blood routine analyzer and ELISA respectively. Results Compared with before treatment, the clinical curative effect and the pulmonary function index were significantly improved after treatment in the two groups. Compared with the control group, the clinical curative effect and the pulmonary function index of the observation group were improved more significantly, the incidence of palpitation decreased significantly (P<0.05), the levels of EOS and IL-25 in peripheral blood were decreased, while the levels of IL-35 were increased, showing statistical differences (P<0.05). Conclusion In patients with COPD, Tiotropium Bromide spray inhalation treatment has significant clinical effect and good safety, and regulating the expression levels of EOS, IL-25 and IL-35 in peripheral blood may play a role in its efficacy, which is worthy of clinical promotion and application.

Key words: tiotropium bromide, COPD, lung function, inflammatory factor