MIG-7及MMP-2在结肠癌中的表达及意义

承德医学院学报 ›› 2018, Vol. 35 ›› Issue (5): 363-366.

MIG-7及MMP-2在结肠癌中的表达及意义

李明玉¹, 贾喜花^2,△, 周炳娟², 张丙信²

1.承德医学院,河北承德 067000;
2.保定市第一中心医院

收稿日期:2018-03-13 出版日期:2018-10-10 发布日期:2021-11-21
通讯作者: △

EXPRESSION AND SIGNIFICANCE OF MIG-7 AND MMP-2 IN COLON CANCER

LI Ming-yu, JIA Xi-hua, ZHOU Bing-juan, et al

Chengde Medical College, Hebei Chengde 067000, China

Received:2018-03-13 Online:2018-10-10 Published:2021-11-21

摘要/Abstract

摘要： 目的: 研究迁移诱导蛋白7（MIG-7）和基质金属蛋白酶2（MMP-2）在结肠癌中的表达及临床意义。方法: 采用免疫组化法观察70例结肠癌组织与对应癌旁组织MIG-7及MMP-2的表达情况,并分析MIG-7及MMP-2与结肠癌临床病理特征的关系及结肠癌组织中二者表达的相关性。结果: 70例结肠癌组织中MIG-7、MMP-2的阳性率分别为61.43%、70.00%,均明显高于癌旁正常组织(P<0.05)。结肠癌组织中,MIG-7及MMP-2的表达与性别、年龄和肿瘤直径无关(P>0.05),与分化程度和淋巴结转移有关(P<0.05)。并且,结肠癌组织MIG-7与MMP-2的表达呈正相关关系(r=0.506,P<0.05)。结论: MIG-7和MMP-2可能共同参与了结肠癌的生长和转移过程。

关键词: 结肠癌, 迁移诱导蛋白7, 基质金属蛋白酶2

Abstract: Objective: To study the expression and significance of migration induced protein-7 (MIG-7) and matrix metalloproteinase-2 (MMP-2) in colon cancer. Methods: Immunohistochemical staining was used to detect the expression of MIG-7 and MMP-2 in 70 cases of colon cancer tissues and corresponding adjacent normal tissues. The relationships between MIG-7, MMP-2 and the clinicopathological characteristics of colon cancer, and the correlations between MIG-7 and MMP-2 in colon cancer tissues were also analyzed. Results: The positive expression rate of MIG-7 and MMP-2 in 70 cases of colon cancer tissues were 61.43% and 70.00% respectively, which were all singnificantly higher than adjacent normal tissues (P˂0.05). In colon cancer, the expression of MIG-7 and MMP-2 were related to differentiation and lymph node metastasis (P˂0.05); but irrelevant to sex, age and tumor size (P>0.05). In colon cancer, the expression of MIG-7 was positively correlated with MMP-2 (r=0.506,P˂0.05). Conduidons: MIG-7 and MMP-2 may participate in the growth and metastasis of colon cancer together.

Key words: Colon cancer, MIG-7, MMP-2

中图分类号:

R735.3

李明玉, 贾喜花, 周炳娟, 张丙信. MIG-7及MMP-2在结肠癌中的表达及意义[J]. 承德医学院学报, 2018, 35(5): 363-366.

LI Ming-yu, JIA Xi-hua, ZHOU Bing-juan, et al. EXPRESSION AND SIGNIFICANCE OF MIG-7 AND MMP-2 IN COLON CANCER[J]. Journal of Chengde Medical University, 2018, 35(5): 363-366.

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