断指再植术后应用前列地尔、丹参多酚酸盐、灯盏细辛的效果对比

承德医学院学报 ›› 2018, Vol. 35 ›› Issue (5): 369-372.

断指再植术后应用前列地尔、丹参多酚酸盐、灯盏细辛的效果对比

傅强¹, 王宝石², 袁辉¹, 梁永超¹, 刘伟亮¹

1.中铁山桥集团医院,河北秦皇岛 066200;
2.秦皇岛市第一医院

收稿日期:2018-03-26 出版日期:2018-10-10 发布日期:2021-11-21

COMPARISON OF THE EFFECTS OF ALPROSTADIL, SALVIANOLATE AND ERIGERON BREVISCAPUS AFTER REPLANTATION OF SEVERED FINGER

<a href="http://tougao.cdmc.edu.cn:8088/EN/article/advancedSearchResult.do?searchSQL=(((FU Qiang[Author]) AND 1[Journal]) AND year[Order])" target="_blank">FU Qiang</a>,<a href="http://tougao.cdmc.edu.cn:8088/EN/article/advancedSearchResult.do?searchSQL=((( WANG Bao-Shi[Author]) AND 1[Journal]) AND year[Order])" target="_blank"> WANG Bao-Shi</a>,<a href="http://tougao.cdmc.edu.cn:8088/EN/article/advancedSearchResult.do?searchSQL=((( YUAN Hui[Author]) AND 1[Journal]) AND year[Order])" target="_blank"> YUAN Hui</a>,<a href="http://tougao.cdmc.edu.cn:8088/EN/article/advancedSearchResult.do?searchSQL=((( et al[Author]) AND 1[Journal]) AND year[Order])" target="_blank"> et al</a>

Zhongtieshanqiao Group Hospital, Hebei Qinhuangdao 066200, China

Received:2018-03-26 Online:2018-10-10 Published:2021-11-21

摘要/Abstract

摘要： 目的: 观察断指再植术后应用前列地尔、丹参多酚酸盐、灯盏细辛的临床效果。方法: 90例断指再植患者随机分为三组（n=30）,前列地尔组（A组）、丹参多酚酸盐组（B组）和灯盏细辛组（C组）。三组患者均在臂丛神经阻滞麻醉下行断指再植术手术,术后均常规给予三抗及患肢保温等治疗;在此基础上,三组患者术后分别给予前列地尔、丹参多酚酸盐和灯盏细辛进行治疗。比较三组患者断指成活率、血管危象发生情况,术后第1日及第7日的凝血酶原时间（PT）、国际标准化比率（INR）、活化部分凝血酶原时间（APTT）、纤维蛋白原（FIB）、血小板数量（PLT）等实验室指标,以及不良反应。结果: A组患者断指成活率明显高于其它两组,血管危象发生率明显低于其它两组（P<0.05）。术后第1日、第7日,三组患者PT、INR、APTT、FIB、PLT比较,差异均无统计学意义（P>0.05）;三组患者术后第7日的PT、INR、APTT、FIB均明显高于第1日,PLT明显低于第1日（P<0.05）。三组患者不良反应发生率比较差异无统计学意义（P>0.05）。结论: 前列地尔用于断指再植术后的效果优于丹参多酚酸盐和灯盏细辛,值得临床推广应用。

关键词: 断指再植, 血管危象, 前列地尔, 丹参多酚酸盐, 灯盏细辛

Abstract: Objective: To observe the effects of alprostadil, salvianolate and Erigeron breviscapus after replantation of severed finger. Methods: 90 patients with replantation of severed finger were randomly divided into the following 3 groups (n=30): alprostadil group (A group), salvianolate group (B group) and Erigeron breviscapus group (C group). All the patients underwent replantation of severed fingers under brachial plexus block anesthesia, and received routine treatment such as three antibodies and limb heat preservation after operation. The survival rate of finger replantation, vascular crisis, adverse reactions, as well as prothrombin time (PT), international normalized ratio (INR), activated partial thromboplastin time (APTT), fibrinogen (FIB), platelet (PLT) 1 day and 7 days after operation of patients in 3 groups were compared. Results: The survival rate of finger replantation of A group was obviously higher than other 2 groups, but the incidence of vascular crisis of A group was obviously lower than other 2 groups (P˂0.05). There was no significant difference in PT, INR, APTT, FIB and PLT among the 3 groups 1 day and 7 days after operation (P>0.05). The PT, INR, APTT, FIB of patients in 3 groups 7 days after operation were all significantly higher than that 1 day after operation (P˂0.05); but the PLT 7 days after operation was significantly lower than that 1 day after operation (P˂0.05). There was no significant difference in incidence of adverse reactions among the 3 groups (P>0.05). Conclusions: The effects of alprostadil is better than salvianolate and Erigeron breviscapus after replantation of severed finger, so it is worthy of clinical promotion.

Key words: Replantation of severed finger, Vascular crisis, Alprostadil, Salvianolate, Erigeron breviscapus

中图分类号:

R658.1

傅强, 王宝石, 袁辉, 梁永超, 刘伟亮. 断指再植术后应用前列地尔、丹参多酚酸盐、灯盏细辛的效果对比[J]. 承德医学院学报, 2018, 35(5): 369-372.

FU Qiang, WANG Bao-Shi, YUAN Hui, et al. COMPARISON OF THE EFFECTS OF ALPROSTADIL, SALVIANOLATE AND ERIGERON BREVISCAPUS AFTER REPLANTATION OF SEVERED FINGER[J]. Journal of Chengde Medical University, 2018, 35(5): 369-372.

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