[1] Hanahan D,Weinberg RA.Hallmarks of cancer:the next generation[J].Cell,2011,144(5):646-674.
[2] Galluzzi L,Vitale I,Abrams JM,et al.Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012[J].Cell Death Differ,2012, 19(1):107-120.
[3] Crook NE,Clem RJ,Miller LK.An apoptosis-inhibiting baculovirus gene with a zinc finger-like motif[J].Virol,1993,67(4):2168-2174.
[4] Fulda S,Vucic D.Targeting IAP proteins for therapeutic intervention in cancer[J].Nat Rev Drug Discov,2012,11(2):109-124.
[5] Varfolomeev E,Vucic D.(Un) expected roles of c-IAPs in apoptotic and NFκB signaling pathways[J].Cell Cycle,2008,7(11):1511-1521.
[6] Blankenship JW,Varfolomeev E,Goncharov T,et al.Ubiquitin binding modulates IAP antagonist- stimulated proteasomal degradation of c-IAP1 and c-IAP2(1)[J].Biochem J,2009,417(1):149-165.
[7] Fulda S,Vucic D.Targeting IAP proteins for therapeutic intervention in cancer[J].Nat Rev Drug Discov,2012,11(2):109-124.
[8] Fulda S,Debatin KM.Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy[J].Oncogene,2006,25(34):4798-4811.
[9] Levine B,Sinha S,Kroemer G.Bcl-2 family members:dual regulators of apoptosis and autophagy[J].Autophagy,2008,4(5):600-606.
[10] Kurokawa M,Kornbluth S.Caspases and kinases in a death grip[J].Cell,2009,138(5):838-854.
[11] Salvesen GS,Duckett CS.IAP proteins:blocking the road to death’s door[J].Nat Rev Mol Cell Biol,2002,3(6):401-410.
[12] Bratton SB,Salvesen GS.Regulation of the Apaf-1-caspase-9 apoptosome[J].Cell Sci,2010,123(Pt 19):3209-3214.
[13] Vucic D,Dixit VM,Wertz IE.Ubiquitylation in apoptosis:a post-translational modification at the edge of life and death[J].Nat Rev Mol Cell Biol,2011,12(7):439-452.
[14] Ditzel M,Broemer M,Tenev T,et al.Inactivation of effector caspases through nondegradative polyubiquitylation[J].Mol Cell,2008,32(4):540-553.
[15] Eckelman BP,Salvesen GS.The human anti-apoptotic proteins cIAP1 and cIAP2 bind but do not inhibit caspases[J].J Biol Chem,2006,281(6):3254-3260.
[16] Varfolomeev E,Vucic D.(Un)expected roles of c-IAPs in apoptotic and NFkappaB signaling pathways[J].Cell Cycle,2008,7(11):1511-1521.
[17] Ikeda F,Deribe YL,Skanland SS,et al.SHARPIN forms a linear ubiquitin ligase complex regulating NF-kB activity and apoptosis[J].Nature,2011,471(7340):637-641.
[18] Tamm I,Kornblau SM,Segall H,et al.Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias[J].Clin Cancer Res,2000,6(5):1796-1803.
[19] 毕民平,杨定华,李湘竑,等.C-IAP2在肝细胞肝癌中的表达及与临床预后的关系[J].南方医科大学学报,2012,32(7):1020-1025.
[20] 朱明玥,陈帆,高冬梅,等.c-IAP1在宫颈癌中的表达及临床意义[J].中国妇幼保健,2014,29(14):2253-2257.
[21] 王艳,林凤茹.c-IAP1、c-IAP2和Smac与凋亡的关系及其在白血病和恶性肿瘤中的表达[J].临床荟萃,2004,19(24):1419-1421.
[22] Liang XH,Jackson S,Seaman M,et al.Induction of autophagy and inhibition of tumorigenesis by beclin 1[J].Nature,1999,402(6762): 72-676.
[23] Toton E,Lisiak N,Sawicka P,et al.Beclin-1 and its role as a target for anticancer therapy[J].J Physiol Pharmacol,2014,65(4):459-467.
[24] Cao Y,Klionsky DJ.Physiological functions of Atg6/Beclin 1:a unique autophagy-related protein[J].Cell Res,2007,17(10):839-849.
[25] Ogier-Denis E,Codogno P.Autophagy:a barrier or an adaptive response to cancer[J].Biochim Biophys Acta,2003,1603(2):113-128.
[26] Levine B,Yuan J.Autophagy in cell death:an innocent convict?[J].J Clin Invest,2005,115(10): 2679-2688.
[27] Liang C,Feng P,Ku B,et al.Autophagic and tumour suppressor activity of a novel Beclin1- binding protein UVRAG[J].Nature Cell Biol,2006,8(7):688-698.
[28] Pattingre S,Tassa A,Qu X,et al.Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy[J].Cell,2005,122(6):927-939.
[29] Ding YP,Yang XD,Wu Y,et al.Autophagy promotes the survival and development of tumors by participating in the formation of vasculogenic mimicry[J].Oncol Rep,2014,31(5): 2321-2327.
[30] Russell RC,Tian Y,Yuan H,et al.ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase[J].Nature Cell Biol,2013,15(7):741-750.
[31] Yu M,Gou W,Zhao S,et al.Beclin 1 expression is an independent prognostic factor for gastric carcinomas[J].Tumour Biol,2013,34(2):1071-1083.
[32] Furuya D,Tsuji N,Yagihashi A,et al.Beclin 1 augmented cis-diamminedichloroplatinum induced apoptosis via enhancing caspase-9 activity[J].Exp Cell Res,2005,307(1):26-40.
[33] Yang Z,Ghoorun RA,Fan X,et al.High expression of Beclin-1 predicts favorable prognosis for patients with colorectal cancer[J].Clin Res Hepatol Gastroenterol,2015,39(1):98-106.
[34] Won KY,Kim GY,Lim SJ,et al.Decreased Beclin-1 expression is correlated with the growth of the primary tumor in patients with squamous cell carcinoma and adenocarcinoma of the lung[J].Hum Pathol,2012,43(1):62-68.
[35] Giatromanolaki A,Koukourakis MI,Koutsopoulos A,et al.High Beclin 1 expression defines a poor prognosis in endometrial adenocarcinomas[J].Gynecol Oncol,2011,123(1):147-151.
[36] Miracco C,Cosci E,Oliveri G,et al.Protein and mRNA expression of autophagy gene Beclin 1 in human brain tumours[J].Int J Oncol, 2007,30(2):429-436.
[37] Kabeya Y,Mizushima N,Ueno T,et al.LC3,a mammalian homologue of yeast Apg8p,is localized in autophagosome membranes after processing[J].EMBO J,2000,19(21):5720-5728.
[38] Kondo Y,Kanzawa T,Sawaya R,et al.The role of autophagy in cancer development and response to therapy[J].Nat Rev Cancer, 2005,5(9):726-734. |
