小檗碱对AIS患者血清MIF和MONO%的调控作用

承德医学院学报 ›› 2017, Vol. 34 ›› Issue (3): 192-194.

小檗碱对AIS患者血清MIF和MONO%的调控作用

李迎¹, 王佩^2,△, 柴美静², 杨凡², 李红闪², 赵婧²

1.承德医学院,河北承德 067000;
2.保定市第一中心医院

收稿日期:2016-07-23 出版日期:2017-06-10 发布日期:2021-11-26
通讯作者: ^△

REGULATING EFFECTS OF BERBERINE ON SERUM MIF AND MONO% LEVEL OF AIS PATIENTS

Chengde Medical College, Hebei Chengde 067000, China

Received:2016-07-23 Online:2017-06-10 Published:2021-11-26

摘要/Abstract

摘要： 目的: 探讨小檗碱对急性缺血性脑卒中患者（AIS）血清巨噬细胞移动抑制因子（MIF）和单核细胞比率（MONO%）的调控作用。方法: 120例AIS患者随机分为小檗碱组（n=60）和常规组（n=60）,常规组仅给予常规治疗,小檗碱组在常规组治疗的基础上加用小檗碱口服（0.3g,日三次）。所有患者均检测入院第1天、14天时血清MIF、MONO%水平。结果: 小檗碱组、常规组入院第1天MIF、MONO%比较差异无统计学意义（P>0.05）。两组第14天时的MIF、MONO%均明显低于本组第1天（P<0.05）;并且,小檗碱组第14天时的MIF、MONO%明显低于常规组第14天（P<0.05）。结论: 小檗碱可显著降低缺血性脑卒中急性期患者血清MIF和MONO%水平,抑制炎症反应。

关键词: 小檗碱, 急性缺血性脑卒中（AIS）, 巨噬细胞移动抑制因子（MIF）, 单核细胞比率（MONO%）

Abstract: Objective: To investigate the regulating effects of berberine on serum macrophage migration inhibition factor (MIF) and monocytes ratio (MONO%) level of acute ischemic stroke (AIS) patients. Methods: 120 AIS patients were randomly divided into routine treatment group and berberine group with 60 patients in each group. The patients in routine treatment group were given routine treatment; While the patients in berberine group were also given berberine (0.3g, tid) on basis of routine treatment. The serum MIF and MONO% level of patients were respectively detected on the 1^st and 14^th day in hospital. Results: There was no statistically significant difference about serum MIF and MONO% level of patients on the 1^st day in hospital between routine treatment group and berberine group (P>0.05). The serum MIF and MONO% level of patients in 2 group on the 14^th day were obviously lower than the 1^st day (P<0.05); Moreover, the serum MIF and MONO% level of patients in berberine group on the 14^th day were obviously lower than routine treatment group on the 14^th day(P<0.05). Conclusions: Berberine can obviously decrease the serum MIF and MONO% level of AIS patients, and inhibit inflammatory response.

Key words: Berberine, Acute ischemic stroke (AIS), Macrophage migration inhibition factor (MIF), Monocytes ratio (MONO%)

中图分类号:

R743.33

李迎, 王佩, 柴美静, 杨凡, 李红闪, 赵婧. 小檗碱对AIS患者血清MIF和MONO%的调控作用[J]. 承德医学院学报, 2017, 34(3): 192-194.

LI Ying, WANG Pei, CHAI Mei-jing, et al. REGULATING EFFECTS OF BERBERINE ON SERUM MIF AND MONO% LEVEL OF AIS PATIENTS[J]. Journal of Chengde Medical University, 2017, 34(3): 192-194.