糖尿病视网膜病变与MMP-7基因多态性的相关性

承德医学院学报 ›› 2017, Vol. 34 ›› Issue (5): 366-368.

糖尿病视网膜病变与MMP-7基因多态性的相关性

杨洁, 张铁民, 董微丽, 马英慧, 贾淑君

承德医学院附属医院眼科,河北承德 067000

收稿日期:2016-11-09 出版日期:2017-10-10 发布日期:2021-11-29

CORRELATIONS BETWEEN DIABETIC RETINOPATHY AND POLYMORPHISM OF MMP-7 GENE

<a href="http://tougao.cdmc.edu.cn:8088/EN/article/advancedSearchResult.do?searchSQL=(((YANG Jie[Author]) AND 1[Journal]) AND year[Order])" target="_blank">YANG Jie</a>,<a href="http://tougao.cdmc.edu.cn:8088/EN/article/advancedSearchResult.do?searchSQL=((( ZHANG Tie-min[Author]) AND 1[Journal]) AND year[Order])" target="_blank"> ZHANG Tie-min</a>,<a href="http://tougao.cdmc.edu.cn:8088/EN/article/advancedSearchResult.do?searchSQL=((( DONG Wei-li[Author]) AND 1[Journal]) AND year[Order])" target="_blank"> DONG Wei-li</a>,<a href="http://tougao.cdmc.edu.cn:8088/EN/article/advancedSearchResult.do?searchSQL=((( et al[Author]) AND 1[Journal]) AND year[Order])" target="_blank"> et al</a>

Department of Ophthalmology, the Affiliated Hospital of Chengde Medical College, Hebei Chengde 067000, China

Received:2016-11-09 Online:2017-10-10 Published:2021-11-29

摘要/Abstract

摘要： 目的: 探讨基质金属蛋白酶-7（MMP-7）-181A/G基因多态性与2型糖尿病视网膜病变（DR）发病风险的关系。方法: 400例糖尿病（DM）患者根据是否合并DR分为DM组（205例）和DR组（195例）,选取同期健康体检者261例作为对照组。采用限制性片段长度多态性(RFLP)-聚合酶链反应(PCR)检测三组受试者MMP-7-181A/G基因多态性。结果: 三组受试者A、G等位基因频率,A/A、A/G、G/G基因型频率比较,差异无统计学意义（P>0.05）。并且,与A/G+A/A基因型相比,携带G/G基因型不会增加2型糖尿病DR的发病风险。结论: MMP-7-181A/G基因多态性与2型糖尿病视网膜病变的发病无关。

关键词: 基质金属蛋白酶-7, 基因多态性, 糖尿病视网膜病变

Abstract: Objective: To investigate the risk of diabetic retinopathy (DR) and polymorphism of matrix metalloproteinase-7 (MMP-7) -181A/G gene. Methods: 400 diabetes mellitus (DM) patients were divided into DM group (n=205) and DR group (n=195) according to whether combined DR; 261 cases of healthy controls were taken as control group. RFLP-PCR was used to detect the polymorphism of MMP-7-181A/G gene of subjects in 3 groups. Results: There was no statistical significance about A, G allele frequency, and A/A, A/G, G/G genotype frequency among 3 groups (P>0.05). Moreover, compared with A/G+A/A genotype, carrying the G/G genotype didn’t increase the risk of DR. Conclusions: The MMP-7-181A/G gene polymorphism has no relations with retinopathy of type 2 diabetes mellitus.

Key words: Matrix metalloproteinases-7, Gene polymorphism, Diabetic retinopathy

中图分类号:

R587.2

杨洁, 张铁民, 董微丽, 马英慧, 贾淑君. 糖尿病视网膜病变与MMP-7基因多态性的相关性[J]. 承德医学院学报, 2017, 34(5): 366-368.

YANG Jie, ZHANG Tie-min, DONG Wei-li, et al. CORRELATIONS BETWEEN DIABETIC RETINOPATHY AND POLYMORPHISM OF MMP-7 GENE[J]. Journal of Chengde Medical University, 2017, 34(5): 366-368.

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