Abstract: Objective: To investigate the value of invasive continuous intracranial pressure monitoring in treatment of severe traumatic brain injury (sTBI).Methods: 130 cases of sTBI patients were divided into monitoring group and non-monitoring group according to therapies with 65 patients in each group. The patients in monitoring group were given invasive intracranial pressure monitoring after craniotomy; the patients in non-monitoring group were given conventional therapy according to vital signs, conscious state and imaging data. The application of mannitol, GOS score and complications of patients in 2 groups were comparatively analyzed. Results: The application time and dose of mannitol, the incidence of electrolyte disturbance and alimentary tract hemorrhage of patients in monitoring group were obviously lower than that of patients in non-monitoring group (P<0.05). The good prognosis rate of patients in monitoring group after 3 months’ treatment was 81.54% (53/65), which was obviously higher than non-monitoring group (P<0.05). Conclusions: Dynamic monitoring of intracranial pressure with invasive intracranial pressure monitoring technique in sTBI patients is conducive to understand the illness timely, adjust the dosage drugs and improve the prognosis; so it is worthy of application in clinic.

Key words: Traumatic brain injury, Invasive continuous intracranial pressure monitoring, Clinical value

摘要： 目的: 探讨有创持续颅内压监测在重型颅脑外伤(sTBI)救治中的应用价值。方法: 130例sTBI患者根据治疗方式的不同分为监测组和非监测组,每组各65例,其中监测组患者开颅术后行有创颅内压监测,非监测组依据患者的生命体征、意识状态和影像学资料等进行常规治疗。对比分析两组患者甘露醇应用情况、GOS评分和并发症发生情况。结果:与非监测组患者相比,监测组患者甘露醇应用时间、应用剂量,以及电解质紊乱、消化道出血发生率明显降低（P<0.05)。监测组患者治疗3个月后的预后良好率为81.54%（53/65）,明显高于对照组（P<0.05）。结论: 应用有创颅内压监测技术动态监测sTBI患者颅内压的变化情况,有利于及时了解患者病情,调整用药剂量,改善患者预后,值得临床推广应用。

关键词: 颅脑损伤, 有创颅内压监测, 临床价值