Abstract: Objective: To investigate the clinical effects of enhanced heart rate control in the treatment of chronic heart failure (CHF). Methods: 150 cases of CHF patients were randomly divided into treatment group and control group with 75 patients in each group. The patients in control group were treated with conventional medicine; the resting heart rate of patients in treatment group was controlled by metoprolol tartrate on the basis of conventional medicine, and the target heart rate was 50-60/min. The curative effects of 2 groups were evaluated after 12 months’ treatment; as well as the heart rate, left ventricular myocardial weight (LVMV), left ventricular ejection fraction (LVEF), ∆T% and adverse reactions of patients in 2 groups were observed. Results: The total effective rate of treatment group was 94.7% (71/75) after 12 months’ treatment, which was obviously higher than control group (P<0.05). The heart rate of patients in 2 groups all decreased obviously after treatment; Moreover, the heart rate of patients in treatment group was obviously lower than control group (P<0.05). After treatment, the LVMV, LVEF and ∆T% of patients in 2 group improved significantly; And the improvement of treatment group was significantly better than that control group (P<0.05). There was no significant difference about the incidence of adverse reactions between treatment group and control group (6.7% vs 4.0%, P>0.05). Conclusions: Heart rate control in treatment of CHF can significantly improve the curative effects and improve the cardiac function of CHF patients.

Key words: Chronic heart failure, Resting heart rate, β-blocker;

摘要： 目的: 探讨强化心率控制指导药物治疗慢性心力衰竭（CHF）的临床效果。方法: 150例CHF患者随机分为治疗组和对照组,每组各75例。对照组患者给予常规药物治疗,治疗组在对照组治疗方案的基础上采用酒石酸美托洛尔控制患者的静息心率,以50-60次/min为目标心率指导药物治疗。两组均治疗12个月后评价疗效,并观察心率、左心室心肌质量（LVMV）、左心室射血分数（LVEF）、左心室后壁收缩期增厚率（*T%）和不良反应等指标。结果: 治疗12个月后,治疗组总有效率为94.7%（71/75）,明显高于对照组（P<0.05）。治疗后,两组患者的心率明显降低,且治疗组患者治疗后的心率明显低于对照组治疗后（P<0.05）;两组患者治疗后的LVMV、LVEF、*T%均较治疗前明显改善,并且治疗组治疗后的改善情况明显优于对照组（P<0.05）。两组患者不良反应发生率比较,差异无统计学意义（6.7% vs 4.0%,P>0.05）。结论: 在治疗CHF时强化心率控制可明显提高CHF的治疗效果及改善CHF患者的心脏功能。

关键词: 慢性心力衰竭, 静息心率, β受体阻滞剂;