Abstract: Objective: To explore the correlations between serum lipid level and severity of white matter lesions (WML). Methods: The clinical data of 214 WML patients were retrospectively analyzed, and 61 healthy examined people at the same term were taken as control. The blood lipid correlation indexes of all the subjects were detected; and Logistic regression was used to analyze the risk factors of WML. Results: The difference of total cholesterol (TC) and low-density lipoprotein cholesterin between control group and WML group with different severity was statistically significant (P<0.05), which was related to the severity of WML. Logistic regression showed that age, hypertension and TC are risk factors of WML. Conclusions: Clinicians can prevent the occurrence of WML or delay the course of WML by controlling the risk factors of WML, such as hypertension and high TC level.

Key words: White matter lesions (WML), Total cholesterol (TC), Low-density lipoprotein cholesterol

摘要： 目的: 探究血脂水平与脑白质病变（WML）严重程度的关系。方法: 回顾性分析214例WML患者的临床资料,以同期61例健康体检者作为对照组。分别检测所有受试者血脂相关指标,并采用Logistic回归分析方法分析WML的危险因素。结果: 对照组、不同病变程度WML组总胆固醇（TC）、低密度脂蛋白胆固醇比较,差异具有统计学意义（P<0.05）,且与WML病变程度有关。Logistic回归分析结果显示,年龄、高血压、TC是WML的危险因素（P<0.05）。结论: 临床可以从控制高血压、高TC水平等WML的危险因素入手,积极预防WML的发生或延缓WML的进程。

关键词: 脑白质病变, 胆固醇, 低密度脂蛋白胆固醇