EXPRESSION AND SIGNIFICANCE OF IGF-I, IGF-IR AND GLUT-4 IN COLORECTAL CARCINOMA

Journal of Chengde Medical University ›› 2018, Vol. 35 ›› Issue (1): 8-11.

EXPRESSION AND SIGNIFICANCE OF IGF-I, IGF-IR AND GLUT-4 IN COLORECTAL CARCINOMA

Department of Pathology, the Affiliated Hospital of Chengde Medical College, Hebei Chengde 067000, China

Received:2017-05-15 Online:2018-02-10 Published:2021-11-21

大肠癌组织IGF-I、IGF-IR、GLUT-4的表达及意义

刘晓倩, 孙立园, 刘莎莎, 赵杨, 申兴斌^△

承德医学院附属医院病理科,河北承德 067000

通讯作者: △

Abstract

Abstract: Objective: To investigate the expression and significance of insulin-like growth factor-I (IGF-I), insulin-like growth factor-I receptor (IGF-IR) and glucose transporter-4 (GLUT-4) in colorectal carcinoma. Methods: Immunohistochemical stain was used to detect the expression of IGF-I, IGF-IR and GLUT-4 protein in 70 cases colorectal carcinoma, 30 cases colorectal adenoma and 20 cases normal colorectal mucosa; and the correlations of aboving three factors in colorectal carcinoma were also analyzed. Results: The expression of IGF-I, IGF-IR and GLUT-4 in colorectal carcinoma were significantly higher than that of normal colorectal mucosa and colorectal adenoma(P<0.01). In colorectal carcinoma, the expression of IGF-I was positively correlated with IGF-IR and GLUT4 (r=0.412,0.396, P<0.01). Conclusions: IGF-I, IGF-IR and GLUT-4 may play an important role in development of colorectal carcinoma.

Key words: Colorectal carcinoma, IGF-I, IGF-IR, GLUT-4, Immunohistochemisty

摘要： 目的: 探讨大肠癌组织胰岛素样生长因子-I（IGF-I）、胰岛素样生长因子-I受体（IGF-IR）、葡萄糖转运蛋白-4（GLUT-4）的表达和意义。方法: 应用免疫组化染色法检测70例大肠癌组织、30例大肠腺瘤和20例正常大肠黏膜IGF-I、IGF-IR、GLUT-4蛋白的表达情况,并分析大肠癌组织三者表达的相关性。结果: 大肠癌组织IGF-I、IGF-IR、GLUT-4的表达明显高于大肠正常黏膜和大肠腺瘤（P<0.01）;大肠癌组织中,IGF-I表达与IGF-IR和GLUT4表达呈正相关关系（r=0.412、0.396,P<0.01）。结论: IGF-I、IGF-IR、GLUT-4可能在大肠癌的发生发展过程中具有重要作用。

关键词: 大肠癌, 胰岛素样生长因子-I, 胰岛素样生长因子-I受体, 葡萄糖转运蛋白-4, 免疫组织化学

CLC Number:

R735.3

LIU Xiao-qian, SUN Li-yuan, LIU Sha-sha, et al. EXPRESSION AND SIGNIFICANCE OF IGF-I, IGF-IR AND GLUT-4 IN COLORECTAL CARCINOMA[J]. Journal of Chengde Medical University, 2018, 35(1): 8-11.

刘晓倩, 孙立园, 刘莎莎, 赵杨, 申兴斌. 大肠癌组织IGF-I、IGF-IR、GLUT-4的表达及意义[J]. 承德医学院学报, 2018, 35(1): 8-11.

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