Abstract: Objective: To investigate the changes and significance of plasma fibrinogen (FIB) and D-dimer level in patients with different types small vessel disease (CSVD). Methods: The plasma FIB and D-dimer level of 134 CSVD patients and 75 controls were detected and the risk factors of CSVD were analyzed. Results: The ratio of hypertension, plasma FIB level and plasma D-dimer level of CSVD and its subtypes (lacunar infarction/LI, white matter lesions/WML, LI combined WML) patients were all obviously higher than controls (P<0.05). Logistic regression analysis showed that D-dimer was risk factor for CSVD, LI, WML and LI combined WML (P<0.05); FIB was risk factor for CSVD, LI and LI combined WML (P<0.05). Conclusions: As risk factors for CSVD, FIB and D-dimer involve in the development of CSVD, but the risk factors for subtypes of CSVD are different.

Key words: Small vessel disease, Fibrinogen, D-dimer

摘要： 目的: 探讨不同类型脑小血管病（CSVD）患者血浆纤维蛋白原（FIB）、D-二聚体水平的变化及意义。方法: 检测134例CSVD患者和75例对照者血浆FIB、D-二聚体水平,并分析CSVD的危险因素。结果: CSVD及其各亚型（腔隙性脑梗死/LI、脑白质病变/WML、腔隙性脑梗死合并脑白质病变）患者高血压比例、FIB水平、D-二聚体水平均明显高于对照者(P<0.05);Logistic回归分析显示,D-二聚体为CSVD、LI、WML、LI合并WML的危险因素,FIB为CSVD、LI、LI合并WML的危险因素（P<0.05）。结论: FIB、D-二聚体作为CSVD的危险因素参与了CSVD的发生发展过程,但不同亚型的CSVD危险因素存在差异。

关键词: 脑小血管病, 纤维蛋白原, D-二聚体