CHANGES OF NF-ΚB P65 EXPRESSION AND THE CORRELATIONS WITH INFLAMMATION IN SEBORRHEIC KERATOSIS

Journal of Chengde Medical University ›› 2019, Vol. 36 ›› Issue (3): 189-192.

CHANGES OF NF-ΚB P65 EXPRESSION AND THE CORRELATIONS WITH INFLAMMATION IN SEBORRHEIC KERATOSIS

the Affiliated Hospital of Chengde Medical College, Hebei Chengde 067000, China

Received:2018-12-28 Online:2019-06-10 Published:2021-11-18

脂溢性角化病病变组织NF-κB P65表达的变化及与炎症的相关性

王成¹, 杜镇¹, 冯世军², 王翠芹¹, 王艳心¹, 李保强^1△

1.承德医学院附属医院,河北承德 067000;
2.沧州市中心医院

通讯作者: △

Abstract

Abstract: Objective: To investigate the changes of NF-κB P65 expression and its correlations with inflammation in seborrheic keratosis. Methods: Max VisionTM immunohistochemical stain and HE stain were used to detect the expression of NF-κB P65 and inflammation in 77 cases of seborrheic keratosis lesions, perilesional tissues and 10 normal skin tissues. Results: The positive expression rate of NF-κB P65 and the percentage of inflammation were 88.31% (68/77) and 80.52% (62/77) respectively, which were significantly higher than those of perilesional tissues and normal skin tissues (P<0.05). Spearman correlation analysis showed that NF-κB P65 expression is positively correlated to inflammation in seborrheic keratosis (r=0.769, P<0.05). Conclusions: High expression of NF-κB P65 and inflammation may play a synergistic role in development of seborrheic keratosis.

Key words: Seborrheic keratosis, NF-κB P65, Inflammation

摘要： 目的:探讨脂溢性角化病病变组织NF-κB P65表达的变化及与炎症的相关性。方法:采用Max VisionTM免疫组织化学染色法和HE染色分别检测77例脂溢性角化病病变组织、病变周围组织及10例正常皮肤组织中NF-κB P65的表达及炎症情况。结果:脂溢性角化病病变组织NF-κB P65的阳性表达率、伴炎症的比例分别为88.31%（68/77）和80.52%（62/77）,均明显高于病变周围组织和正常组织（P<0.05）。Spearman相关性分析显示,脂溢性角化病病变组织NF-κB P65的阳性表达与炎症呈正相关关系（r=0.769,P<0.05）。结论:NF-κB P65高表达和炎症可能在脂溢性角化病的发生发展过程中具有协同作用。

关键词: 脂溢性角化病, NF-κB P65, 炎症

CLC Number:

R739.5

WANG Cheng, DU Zhen, FENG Shi-jun, et al. CHANGES OF NF-ΚB P65 EXPRESSION AND THE CORRELATIONS WITH INFLAMMATION IN SEBORRHEIC KERATOSIS[J]. Journal of Chengde Medical University, 2019, 36(3): 189-192.

王成, 杜镇, 冯世军, 王翠芹, 王艳心, 李保强. 脂溢性角化病病变组织NF-κB P65表达的变化及与炎症的相关性[J]. 承德医学院学报, 2019, 36(3): 189-192.

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