Abstract: Objective: To investigate the correlations between serum cystatin C level and estimated glomerular filtration rate (eGFR) in patients with early diabetic nephropathy. Methods: 60 patients with early diabetic nephropathy were divided into group A (n=33) and group B (n=27) according to serum cystatin C level; 70 health examination people in our hospital during the same period were selected as group C. The serum cystatin C level, serum creatinine of all the subjects were detected and the eGFR was calculated using MDRD formula. Linear correlation analysis was used to analyze the correlations between serum cystatin C level and eGFR in patients with early diabetic nephropathy. Results: The serum cystatin C level of early diabetic nephropathy patients in group A and group B were all significantly higher than group C, while the eGFR were significantly lower (P<0.05). The serum cystatin C level of early diabetic nephropathy patients was negatively correlated with eGFR (r=-0.7193, P<0.05). Conclusions: The serum cystatin C level is negatively correlated with eGFR in patients with early diabetic nephropathy, which may be a predictor of early diagnosis of diabetic nephropathy.

Key words: Diabetic nephropathy, Cystatin C, Estimated glomerular filtration rate (eGFR), Albumin creatinine rate

摘要： 目的:探讨早期糖尿病肾病患者血清胱抑素水平与估计肾小球滤过率（estimated glomerular filtration rate,eGFR）的相关性。方法:60例早期糖尿病肾病患者根据血清胱抑素C水平分为糖尿病肾病A组33例和糖尿病肾病B组27例,选取同期我院70例健康体检者为参照C组。测定所有受试对象血清胱抑素C水平、血肌酐（serum creatinine,SCr）,并根据MDRD公式计算eGFR;采用直线相关分析早期糖尿病肾病患者血清胱抑素C水平与eGFR的相关性。结果:早期糖尿病肾病A组和B组患者血清胱抑素C水平均明显高于参照C组,eGFR明显低于参照C组,差异有统计学意义（P<0.05）;相关分析结果示,糖尿病肾病患者血清胱抑素C水平与eGFR呈负相关关系（r=-0.7193,P<0.05）。结论:早期糖尿病肾病患者血清胱抑素C水平与eGFR呈负相关关系,其有望成为早期诊断糖尿病肾病的预测因子。

关键词: 糖尿病肾病, 胱抑素C, 估计肾小球滤过率（eGFR）, 尿白蛋白肌酐比率