Abstract: Objective: To explore the treatment effects of labetalol hydrochloride combined with folic acid on early-onset preeclampsia and the effects on maternal-infant outcomes. Methods: Ninety-six patients with early-onset preeclampsia were randomly divided into study group and control group with 48 cases in each group. The patients in control group were treated with conventional treatment and folic acid; On the basis of the control group, the patients in study group were also give labetalol hydrochloride. The blood pressure [systolic blood pressure (SBP), diastolic blood pressure (DBP)], uterine hemodynamics indexes [pulsatility index (PI), resistance index (RI)] before and 1week after treatment, as well as the maternal-infant outcomes (natural delivery, postpartum hemorrhage, placental abruption, neonatal asphyxia, neonatal Apgar score) of patients in 2 groups were compared. Results: 1 week after treatment, the SBP, DBP, PI and RI of patients in 2 groups were significantly decreased compared with those before treatment (P<0.05); And the above indexes of patients in study group after treatment were significantly lower than those in control group after treatment (P<0.05). There were no significant statistical significances about the incidence rates of postpartum hemorrhage, placental abruption and neonatal asphyxia between the two groups (P>0.05). The natural delivery rate and neonatal Apgar score of patients in study group were significantly higher than those in control group (P<0.05). Conclusions: Labetalol hydrochloride combined with folic acid has better effects on treating early-onset preeclampsia, and it can control blood pressure, improve uterine blood supply and neonatal physical condition at birth effectively.

Key words: Labetalol hydrochloride, Folic acid, Early-onset preeclampsia, Maternal-infant outcomes

摘要： 目的 探究盐酸拉贝洛尔联合叶酸治疗早发型子癫前期的效果及对患者母婴结局的影响。方法 96例早发型子痫前期患者为受试对象,采用随机数字法分为研究组与对照组各48例。对照组给予叶酸及常规治疗,研究组在对照组的基础上给予盐酸拉贝洛尔进行治疗。比较两组患者治疗前及治疗1周后的血压[收缩压（SBP）、舒张压（DBP）]、子宫血流动力学指标[搏动指数（PI）、阻力指数（RI））],以及两组患者的母婴结局（自然分娩、产后出血、胎盘早剥、新生儿窒息、新生儿Apgar评分）。结果 治疗1周后,两组患者的SBP、DBP、PI、RI均较治疗前显著下降,且研究组明显低于对照组（P<0.05）。两组产后出血、胎盘早剥、新生儿窒息发生率比较无显著差异（P>0.05）;研究组自然分娩率及新生儿Apgar评分明显高于对照组（P<0.05）。结论 盐酸拉贝洛尔联合叶酸治疗早发型子癫前期具有良好的效果,能够有效控制患者血压,改善患者子宫血供及新生儿出生时的身体状况。

关键词: 盐酸拉贝洛尔, 叶酸, 早发型子癫前期, 母婴结局