Abstract: Objective To observe the clinical effect of minimally invasive holmium laser bladder tumor resection for superficial bladder tumors through the urethra. Methods From June 2016 to December 2019, 64 patients with superficial bladder tumor who admitted to our hospital were selected as the research object, and divided into HOLRBT group and TURBT group (32 cases each) by random double blind method. The group was treated with transurethral holmium laser bladder tumor resection, and the TURBT group was treated with transurethral resection of bladder tumor. Observation of the operation, stress response and complications of the two groups was performed. Results Compared with the TURBT group, the intraoperative blood loss, bladder irrigation time, urinary indwelling time and hospital stay in the HOLRBT group were shorter (P<0.05), but the operation time of two groups was not statistically significant (P>0.05). The stress response indexes (E, ATⅡ, NE) in the HOLRBT group during operation and 6 hours after operation were significantly lower than those in the TURBT group (P<0.05). The total postoperative complication rate (9.38%) in the HOLRBT group was significantly lower than TURBT Group (31.25%) (P<0.05). Conclusion Transurethral minimally invasive holmium laser bladder tumor resection can reduce the amount of intraoperative bleeding, shorten the bladder irrigation time, indwelling catheter time and hospitalization stay, improve its stress response level, and reduce the incidence of postoperative complications, which is worthy of extensive clinical promotion.

Key words: transurethral minimally invasive holmium laser bladder tumor resection, superficial bladder tumor, transurethral resection of bladder tumor

摘要： 目的 观察浅表膀胱肿瘤经尿道行微创钬激光膀胱肿瘤切除术治疗的临床效果。方法 选取2016年6月至2019年12月我院泌尿外科收治的64例浅表膀胱肿瘤患者为研究对象,采用随机双盲法将其分为HOLRBT组与TURBT组（各32例）,HOLRBT组行经尿道行微创钬激光膀胱肿瘤切除术治疗,TURBT组行经尿道膀胱肿瘤电切术治疗,观察两组患者手术情况、应激反应及并发症发生情况。结果 与TURBT组比较,HOLRBT组术中出血量、膀胱冲洗时间、尿管留置时间及住院时间均较短（P<0.05）,但两组患者手术时间比较无统计学意义（P>0.05）;HOLRBT组术中及术后6h应激反应指标（E、ATⅡ、NE）水平均显著低于TURBT组（P<0.05）;HOLRBT组术后并发症总发生率（9.38%）显著低于TURBT组（31.25%）（P<0.05）。结论 经尿道行微创钬激光膀胱肿瘤切除术治疗可降低患者术中出血量,缩短膀胱冲洗时间、留置尿管时间及住院时间,改善其应激反应水平,降低术后并发症发生率,值得临床广泛推广。

关键词: 经尿道微创钬激光膀胱肿瘤切除术, 浅表膀胱肿瘤, 经尿道膀胱肿瘤电切术