Abstract: Objective To study AMI effect of early plasma renin on the long-term prognosis of AMI patients after optimized treatment. Methods Fifty-eight patients with acute myocardial infarction were hospitalized in the Department of Cardiology of the Affiliated Hospital of Chengde Medical University from October 2018 to October 2019. The general clinical data and laboratory examination indexes of the patients were recorded, and the plasma renin concentration after lying flat for 6 hours was measured for 1 week The left ventricular end diastolic anteroposterior diameter (LVEDD) and left ventricular ejection fraction(LVEF) were measured by echocardiography. LVEDD, LVEF The values of the 6-minute walk test(6MWT) and follow-up recorded major adverse cardiovascular events(MACE) was divided into high renin group and low renin group according to the plasma renin concentration. The differences of LVEDD, LVEF, 6MWT and mace between the two groups after 1 year were compared, and the differences of LVEDd and LVEF during hospitalization and 1 year after discharge were compared. Results After 1 year of follow-up, there was no significant difference in LVEDd, LVEF, 6MWT and mace between the high renin group and the low renin group(P>0.05). One year after discharge, LVEF was significantly higher than that during hospitalization (P<0.001). Conclusion The early plasma renin in patients with AMI after optimized treatment has no effect on the 1-year prognosis, and the cardiac function of patients with acute myocardial infarction can be improved after optimized treatment for 1 year.

Key words: renin, acute myocardial infarction, echocardiography, 6-minute walk test, long-term prognosis

摘要： 目的 研究早期血浆肾素对经优化治疗的AMI患者远期预后的影响。方法 纳入2018年10月~2019年10月于承德医学院附属医院心内科被诊断为AMI并住院治疗的患者58例。记录患者的一般临床资料和实验室检查指标,测平卧6h后血浆肾素浓度,入院1周内通过超声心动图测量患者的左心室舒张末期前后径（LVEDD）和左心室射血分数（LVEF)的值。出院1年后再次测量患者的LVEDD、LVEF、6min步行试验（6MWT）的数值和随访记录主要不良心血管事件（MACE）,依据血浆肾素浓度分为高肾素组和低肾素组,比较2组患者1年后LVEDD、LVEF、6MWT、MACE的差异,比较住院期间与出院1年后LVEDD、LVEF的差异。结果 出院随访1年后,高肾素组与低肾素组在LVEDD、LVEF、6MWT、MACE方面上的差异均无统计学意义（P>0.05）,出院1年后LVEF较住院期间显著升高（P<0.001）。结论 经优化治疗的AMI患者早期血浆肾素对1年预后无影响,急性心肌梗死患者经优化治疗1年后心脏功能可以得到改善。

关键词: 肾素, 急性心肌梗死, 超声心动图, 6min步行试验, 远期预后