Abstract: Objective The purpose of this research is to analyze the presence of climacteric syndromes in perimenopausal women with normal body weight and varying waist hip ratios (WHR). Furthermore, the investigation will explore the connection between abdominal obesity and climacteric syndromes in this group. Methods According to the 2011 stages of the Reproductive Ageing Workshop (STRAW+10), this study was conducted among 335 perimenopausal women who met the inclusion and exclusion criteria and admitted to the departmem of Endocrinology and the Department of Gynecology, Beijing ChuiYangLiu Hospital from June 2018 to June 2019. According to WHR, these women were divided into normal group (group A) and abdominal obesity group (group B). The modified Kupperman Index was used to evaluate climacteric syndromes, an examination of the total score and scores of each dimension of KMI between the two groups was conducted.. The correlation between WHR and the KMI scores, as well as each dimension score, was evaluated by Pearson correlation analysis. Results The scores of KMI, hot flashes, sensory disturbance, insomnia in group B were significantly higher than those in group A (P<0.05). WHR was positively correlated with the scores of KMI hot flashes, sensory disturbance and insomnia (P<0.05). Conclusion This study reveals that abdominal obesity in perimenopausal women were positively correlated with the severity of climacteric syndrome. It is imperative that clinicians give weight management education and tailored health guidance to women in their daily practice.

Key words: trastuzumab, SOX scheme, human epidermal growth factor receptor 2, advanced gastric cancer, tumor marker, immune function

摘要： 目的 调查正常体重指数（BMI）围绝经期女性的围绝经期综合征状况,分析腹型肥胖对围绝经期女性更年期综合征的影响。方法 根据“生殖衰老研讨会分期+10”,纳入2018年6月~2019年6月在北京市垂杨柳医院妇科以及内分泌科就诊并且符合纳入、排除标准的335例围绝经期女性为研究对象。根据腰臀比（WHR）分为正常组（A组）和腹型肥胖组（B组）。采用改良Kupperman评分表（KMI）评估围绝经期症状,比较KMI总分及各维度评分在2组间的差异,通过Pearson相关性分析评估WHR与KMI评分以及各维度评分间的关系。结果 在2组不同WHR的围绝经期女性中,B组围绝经期女性的KMI总分以及潮热出汗、感觉障碍、失眠3个维度的评分比较差异有统计学意义（P<0.05）;WHR与KMI评分以及潮热出汗、感觉障碍、失眠3个维度呈正相关关系（P<0.05）。结论 正常BMI的围绝经期女性腹型肥胖与围绝经期综合征的严重程度呈正相关关系,临床医生在日常工作中有必要对此时期的女性进行体重管理教育和有针对性的健康指导。

关键词: 体重指数, 肥胖, 腹型肥胖, 围绝经期综合征, 女性健康