Abstract: Objective To analyze the effect and safety of phloroglucinol on the observation of the esophagogastric junction during painless gastroscopy. Method A control group consisting of 135 cases underwent painless gastroscopy, and an observation group consisting of 115 cases(painless gastroscopy plus phloroglucinol) was randomly formed from patients who underwent painless gastroscopy between September 2022 and February 2023 based on the odd-evenness of their registration numbers. The esophagogastric junction observation effect, lesion detection rate, endoscopic features of lesions, pathological outcomes, and intraoperative and postoperative adverse responses of the two patient groups were noted and monitored. Result This portion of the observation group had a greater observation rate of the esophagogastric junction and a higher rate of lesion detection than the control group, and the difference was statistically significant (P=0.038, P=0.035). In comparison to the control group, the observation group had a greater detection rate of non-red lesions; this difference is statistically significant (P=0.003). Between the two groups, there was no statistically significant difference in the occurrence of adverse responses or pathological results (P>0.05). The difference was statistically significant (P=0.003). The incidence of adverse responses and abnormal outcomes did not change statistically significantly between the two groups (P>0.05). Conclusion The esophagogastric junction's observation impact can be enhanced by applying phloroglucinol before the painless gastroscopy, which will increase the likelihood of lesions being discovered. Finding easily overlooked non-red lesions is one of its specific uses. Additionally, it is more secure and has fewer adverse effects.

Key words: painless gastroscopy, phloroglucin, esophagogastric junction, efficacy observation

摘要： 目的 分析间苯三酚应用于无痛胃镜中对食管胃结合部观察效果的影响及安全性。方法 选取2022年9月~2023年2月于承德市中心医院行无痛胃镜检查患者,按患者登记号的奇偶性随机分为对照组（无痛胃镜组）135例,观察组（无痛胃镜加用间苯三酚组）115例。观察记录2组患者食管胃结合部观察效果、病变检出率、病变内镜下特征、病理结果、术中术后不良反应发生情况。结果 观察组食管胃结合部易观察率及该部位病变检出率均高于对照组,差别有统计学意义（P=0.038,P=0.035）,观察组非红色调病变检出率高于对照组,差异有统计学意义（P=0.003）。2组病理结果及不良反应发生率比较差别无统计学意义（P>0.05）。结论 无痛胃镜检查前应用间苯三酚,有助于改善食管胃结合部观察效果,从而增加病变检出率,尤其对易漏诊的非红色调病变的检出具有优势,且不良反应较少,安全性较高。

关键词: 无痛胃镜, 间苯三酚, 食管胃结合部, 观察效果