Abstract: Objective To investigate the relationship between serum galactin-3 (Gal-3) and high mobility histone 1 (HMGB1) levels and prognosis after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI). Methods A total of 115 patients with AMI were included in this study. All patients received PCI and were followed up for half a year after treatment. Patients with and without adverse cardiovascular events were divided into MACE group (35 cases) and reference group (80 cases), respectively. Serum Gal-3, HMGB1 and cTnⅠ, CRP and other indexes were detected and compared before and after operation, and the levels of cTnⅠ, CRP, serum Gal-3 and HMGB1 were compared between the MACE group and the reference group. Receiver operating characteristic (ROC) curve was used to analyze the value of the above indexes in predicting the poor prognosis of patients with acute myocardial infarction. Results The levels of serum Gal-3 and HMGB1 after operation were higher than those before operation (P<0.05). Compared with the reference group, the indexes of cardiac function and inflammatory factors in MACE group were increased, while the indexes of left ventricular ejection fraction (LVEF) were decreased in MACE group (all P<0.05). Serum Gal-3 and HMGB1 levels in MACE group were higher than those in reference group (P<0.05). The AUC values of serum Gal-3 and HMGB1 indexes for predicting poor prognosis in patients with acute myocardial infarction were 0.723 and 0.708, respectively, and the sensitivity were 61.40% and 54.55%, respectively, while the AUC values of combined prediction were 0.791 and the sensitivity was 82.43%, both of which were higher than the single detection of each indicator. Conclusion The levels of serum Gal-3 and HMGB1 indexes in patients with acute myocardial infarction showed an abnormal increase trend, and the combined detection of these indexes is of high clinical value in predicting the occurrence of MACE in patients with acute myocardial infarction.

Key words: Acute myocardial infarction, Galectin-3, High mobility histone 1, Percutaneous coronary intervention, Prognosis

摘要： 目的 探讨急性心肌梗死（AMI）患者血清半乳糖凝集素-3（Gal-3）、高迁移率组蛋白1（HMGB1）水平及与经皮冠状动脉介入治疗（PCI）术后预后的关系。方法 本研究共纳入115例AMI患者作为研究对象,所有患者均接受PCI治疗,治疗结束后均进行为期半年的随访,分别将发生和未发生不良心血管事件的患者分别设为MACE组(35例)和参照组(80例)。对患者手术前后血清Gal-3、HMGB1指标及cTnⅠ、CRP等指标进行检测并对比,将MACE组、参照组患者cTnⅠ、CRP、血清Gal-3及HMGB1指标水平进行对比,采用受试者工作特征（ROC）曲线对上述指标预测AMI患者预后不良的价值进行分析。结果 术后患者血清Gal-3、HMGB1指标水平相较于术前升高（P<0.05）;MACE组患者心功能指标、炎症因子等均相较于参照组升高,而左室射血分数（LVEF）指标水平则相较于参照组下降（均P<0.05）;MACE组患者血清Gal-3、HMGB1指标水平相较于参照组升高（P<0.05）;血清Gal-3、HMGB1指标预测AMI患者预后不良的AUC值分别为0.723、0.708,灵敏度分别为61.40%、54.55%,而联合预测的AUC值为0.791,灵敏度为82.43%,均相较于各项指标单项检测升高。结论 AMI患者血清Gal-3、HMGB1指标水平均呈异常升高趋势,将上述指标联合检测应用于AMI患者发生MACE的预测中临床价值较高。

关键词: 急性心肌梗死, 半乳糖凝集素-3, 高迁移率组蛋白1, 经皮冠状动脉介入治疗, 预后