Changes and Significance of Serum Immunoinflammatory Indexes and 25-hydroxyvitamin D Levels in Patients with Vestibular Neuritis

Abstract

Abstract: Objective To investigate the changes and significance of serum immunoinflammatory indexes and 25-hydroxyvitamin D (25-OH-D) levels in patients with vestibular neuritis. Methods A total of 120 patients with vestibular neuritis admitted to the Third People's Hospital of Henan Province from June 2021 to June 2023 were selected as the study group, and 100 healthy people without vertigo or balance disorder who underwent physical examination in the same period were selected as the reference group to conduct a prospective study. Baseline data of the two groups of subjects were collected, serum immunoinflammatory indicators and 25-OH-D levels were detected and compared. Multivariate binary Logistic regression was used to analyze the risk factors of vestibular neuritis, and Pearson related software was used to analyze the correlation between serum 25-OH-D levels and immunoinflammatory indicators. Results There were no significant differences in age, sex and body mass index between the two groups (all P>0.05). Neutrophil/lymphocyte ratio (NLR), C-reactive protein (CRP) and CD8⁺ percentage were increased, while 25-OH-D, CD3⁺, CD4⁺ percentage and CD4⁺/CD8⁺ ratio were decreased in study group compared with reference group (all P<0.05). There were no significant differences in total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) between 2 groups (all P>0.05). Multivariate Logistic regression analysis showed that 25-OH-D and CRP were independent risk factors for vestibular neuritis (OR =1.125, 1.234, P<0.05). According to Pearson analysis, serum 25-OH-D level in vestibular neuritis patients was positively correlated with CD4⁺/CD8⁺ (r=0.518, P<0.05), but negatively correlated with CRP (r=-2.219, P<0.05). Conclusion Serum 25-OH-D level in patients with vestibular neuritis was significantly decreased compared with the control group. Both 25-OH-D and CRP were independent risk factors for vestibular neuritis, and serum 25-OH-D level in patients with vestibular neuritis was positively correlated with CD4⁺/CD8⁺, while negatively correlated with CRP. Vitamin D supplementation in patients with vestibular neuritis may be a new target for the treatment of this disease.

Key words: Vestibular neuritis, Immunoinflammatory index, 25-hydroxyvitamin D

摘要： 目的探讨前庭神经炎患者血清免疫炎症指标和25-羟维生素D（25-OH-D）水平变化及意义。方法选取2021年6月~2023年6月河南省直第三人民医院收治的120例前庭神神经炎患者,将其作为研究组,同时选择同期于本院进行体检的100例无眩晕或无平衡障碍疾病的健康人群,将其作为参照组,进行前瞻性研究。采集2组研究对象基线资料,检测血清免疫炎症指标、25-OH-D水平并对比,采用多因素二元Logistic回归分析前庭神经炎发生的危险因素,采用Pearson相关软件分析血清25-OH-D水平与免疫炎症指标的相关性。结果 2组研究对象年龄、性别、体质量指数等基线资料进行对比,均无明显差异（均P>0.05）;研究组患者中性粒细胞/淋巴细胞比值（NLR）、C-反应蛋白（CRP）、CD8⁺百分比相较于参照组升高,25-OH-D、CD3⁺、CD4⁺百分比及CD4⁺/CD8⁺比值相较于参照组下降（均P<0.05）,而2组研究对象总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、免疫球蛋白A（IgA）、免疫球蛋白M（IgM）、免疫球蛋白G（IgG）比较,差异均无统计学意义（均P>0.05）;多因素二元Logistic回归分析结果显示,25-OH-D、CRP均为前庭神经炎发生的独立危险因素（OR=1.125、1.234,均P<0.05）;Pearson相关软件分析,前庭神经炎患者血清25-OH-D水平与CD4⁺/CD8⁺之间呈正相关（r=0.518,P<0.05）,而与CRP之间呈负相关（r=-2.219,P<0.05）。结论前庭神经炎患者的血清25-OH-D水平相较于参照组显著下降,25-OH-D、CRP均为前庭神经炎发生的独立危险因素,且前庭神经炎患者血清25-OH-D水平与CD4⁺/CD8⁺之间呈正相关,而与CRP之间呈负相关,对前庭神经炎患者进行维生素D的补充治疗可作为该疾病治疗的新靶点。

关键词: 前庭神经炎, 免疫炎症指标, 25-羟维生素D

CLC Number:

R764.4

YAN Rui-hong, LIU Shi-qing. Changes and Significance of Serum Immunoinflammatory Indexes and 25-hydroxyvitamin D Levels in Patients with Vestibular Neuritis[J]. Journal of Chengde Medical University, 2024, 41(6): 475-479.

闫瑞红, 柳世清. 前庭神经炎患者血清免疫炎症指标和25-羟维生素D水平变化及意义[J]. 承德医学院学报, 2024, 41(6): 475-479.

Add to citation manager EndNote|Ris|BibTeX

URL: http://tougao.cdmc.edu.cn:8088/EN/

http://tougao.cdmc.edu.cn:8088/EN/Y2024/V41/I6/475

References

[1] 杨云鹏,张爱香,任蓓,等. 鼠神经生长因子联合强的松治疗对老年急性前庭神经炎患者前庭功能和氧化应激水平的影响[J]. 海南医学,2021,32(2):160-164.
[2] 陈瑛,庄建华,李斐,等. 视频头脉冲试验检测前庭神经炎急性期半规管的受损情况及其恢复特点的应用[J]. 第二军医大学学报,2018,39(1):97-100.
[3] 王雯,杨月嫦,庄建华,等. 前庭性偏头痛与前庭神经炎患者的变温试验及视频头脉冲试验结果差异分析[J]. 临床耳鼻咽喉头颈外科杂志,2018,32(9):647-652.
[4] 菅慧蓉,胡娜,李霄飞,等. 前庭神经炎患者内耳3D-FLAIR MRI特点与前庭功能相关性分析[J]. 中华耳鼻咽喉头颈外科杂志,2022,57(5):578-583.
[5] 熊水灵,陈钢钢,陈英,等. 前庭神经炎患者血清25-羟维生素D表达水平及其相关性研究[J]. 临床耳鼻咽喉头颈外科杂志,2022,36(8):607-612.
[6] 李秀花,孟萌,宋江曼,等. 前庭神经炎患者25羟维生素D和C反应蛋白水平的研究[J]. 中风与神经疾病杂志,2021,38(9):829-832.
[7] 中国医师协会神经内科分会眩晕专业委员会,中国卒中学会卒中与眩晕分会,李斐,等. 前庭神经炎诊治多学科专家共识[J]. 中华老年医学杂志,2020,39(9):985-994.
[8] 禹松林,方慧玲,张瑞苹,等. 改良超高效液相色谱串联质谱法测定25-羟基维生素D2和25-羟基维生素D3[J]. 检验医学,2015,30(10):1021-1026.
[9] 王延辉,薛瑞,袁杰,等. 鼠神经生长因子联合糖皮质激素治疗急性前庭神经炎疗效研究[J]. 陕西医学杂志,2018,47(11):1474-1476.
[10] 胡惠惠,刘亚,程博. 针刺治疗对前庭神经炎患者眩晕症状、平衡功能及前庭功能的影响[J]. 贵州医药,2022,46(3):447-448.
[11] 黄瓅. 甲钴胺联合泼尼松对老年前庭神经炎患者前庭功能和炎症介质水平的影响[J]. 中国药物经济学,2019,14(9):69-71.
[12] 王朝霞,徐先荣,李远军,等. 激素联合前庭康复治疗与单纯激素治疗前庭神经炎的临床效果观察[J]. 临床耳鼻咽喉头颈外科杂志,2019,33(6):493-497.
[13] 李凤榕,刘坤鹏,韩威威,等. 中性粒细胞/淋巴细胞比值和血小板/淋巴细胞比值与前庭神经炎的相关性研究[J]. 中风与神经疾病杂志,2021,38(6):492-495.
[14] 陈瑛. 前庭神经炎病程不同阶段的临床特点及静态、动态前庭功能研究[D]. 上海:中国人民解放军海军军医大学,2015.
[15] 陈英,裴婷,张海利. 血清25-羟维生素D水平与前庭神经炎的相关性研究[J]. 中国耳鼻咽喉颅底外科杂志,2020,26(5):594-598.
[16] 张盛斌,郑吼真,张淇钏,等. 血清25-羟维生素D水平与COPD急性加重期患者免疫炎症指标、CAT评分的相关性研究[J]. 广东药科大学学报,2020,36(5):719-723.