Abstract: Objective To explore the correlation between the levels of serum miR-485 and miR-205-5p and the efficacy of chemotherapy in patients with ovarian cancer (OC). Methods A retrospective study was conducted on 114 patients with OC admitted to Nanyang Central Hospital from December 2020 to December 2023. These patients were divided into three groups based on the effect of chemotherapy after four cycles: remission group (59 cases), stable group (31 cases), and deterioration group (24 cases). The serum levels of miR-485 and miR-205-5p before chemotherapy, after two cycles of chemotherapy and after four cycles of chemotherapy were compared among the three groups, and the correlation was analyzed. The predictive value of combined detection of serum levels of miR-485 and miR-205-5p for chemotherapy effect in patients with OC was analyzed. Results The serum miR-485 level in the deterioration group was lower than that in the stable group and the remission group, and the stable group was lower than that in the remission group (P<0.05), the serum miR-205-5p level in the deterioration group was higher than that in the stable group and the remission group, and the stable group was higher than that in the remission group, the differences were statistically significant (P<0.05); serum miR-485 level before chemotherapy<after 2 cycles of chemotherapy<after 4 cycles of chemotherapy, serum miR-205-5p level before chemotherapy>after 2 cycles of chemotherapy>after 4 cycles of chemotherapy, the differences were statistically significant (P<0.05); Serum miR-485 level was negatively correlated with the effect of chemotherapy, and serum miR-205-5p level was positively correlated with the effect of chemotherapy, the differences were statistically significant (P<0.05); the area under the ROC curve (AUC) of serum levels of miR-485 and miR-205-5p combined to predict the deterioration of chemotherapy results in patients with OC after two cycles of chemotherapy was 0.846, and the best diagnostic sensitivity was 87.50%, specificity was 84.44%, the differences were statistically significant P<0.05). Conclusion The serum levels of miR-485 and miR-205-5p are closely related to the effect of chemotherapy in patients with OC, which can provide an effective reference for clinical prediction of chemotherapy effect.

Key words: miR-485, miR-205-5p, Ovarian cancer, Chemotherapy

摘要： 目的 探讨血清miR-485、miR-205-5p水平与卵巢癌（OC）患者化疗效果的相关性。方法 回顾性选取2020年12月~2023年12月南阳市中心医院收治的114例OC患者为研究对象,依照化疗4个周期后效果分为缓解组（59例）、稳定组（31例）、恶化组（24例）。比较3组化疗前、化疗2个周期后、化疗4个周期后血清miR-485、miR-205-5p水平并分析相关性,分析血清miR-485、miR-205-5p水平联合检测对OC患者化疗效果的预测价值。结果 恶化组血清miR-485水平比稳定组、缓解组低,且稳定组比缓解组低（P<0.05）,恶化组血清miR-205-5p水平比稳定组、缓解组高,且稳定组比缓解组高,差异有统计学意义（P<0.05）;化疗前血清miR-485水平<化疗2个周期后<化疗4个周期后,血清miR-205-5p水平>化疗2个周期后>化疗4个周期后,差异有统计学意义（P<0.05）;血清miR-485与化疗效果呈负相关,血清miR-205-5p水平与化疗效果呈正相关,差异有统计学意义（P<0.05）;化疗2个周期后血清miR-485、miR-205-5p水平联合预测OC患者化疗结果恶化的受试者操作特征曲线（ROC）曲线下面积（AUC）为0.846,最佳诊断灵敏度为87.50%,特异度84.44%,差异有统计学意义（P<0.05）。结论 血清miR-485、miR-205-5p水平与OC患者化疗效果密切相关,可为临床预测化疗效果提供有效参考。

关键词: miR-485, miR-205-5p, 卵巢癌, 化疗