Abstract: Objective To investigate the relationship between the expression of TLR8, TRPM8 and Bach2 and postoperative recurrence of Chronic rhinosinusitis with nasal polyps (CRSwNP). Methods A total of 120 patients with chronic rhinosinusitis and nasal polyps who underwent endoscopic surgery in Anyang Regional Hospital of Puyang City from June 2021 to June 2023 were selected. After 1 year of operation, the postoperative recurrence was counted, and 6 cases were lost. According to the severity of the disease, they were divided into mild group (Lund-Mackay score <4 points, n = 19), moderate group (Lund-Mackay score 4-15 points, n = 17), and severe group (Lund-Mackay score >15 points, n = 13). The expressions of TLR8, TRPM8 and Bach2 in the two groups were compared, and the correlation between the three and the recurrence of chronic rhinosinusitis with nasal polyps after endoscopic surgery was analyzed. Results The expression levels of TLR8, TRPM8, Bach2 and inflammatory factors in the study group were higher than those in the control group (P<0.05). Compared with the mild group, the expression levels of TLR8, TRPM8, Bach2 in the moderate group and the severe group were higher than those in the mild group (P<0.05). Compared with the moderate group, the expression levels of TLR8, TRPM8 and Bach2 in the severe group were higher than those in the moderate group (P<0.05). Compared with the severe group, the mild group had significantly lower expression levels of TLR8, TRPM8 and Bach2 (P<0.05). The levels of TLR8 and TRPM8 in patients with recurrent chronic rhinosinusitis with nasal polyps after endoscopic surgery were positively correlated (r=7.964, P=0.006). The levels of TLR8 and Bach2 were positively correlated (r=10.640, P=0.001). The levels of TRPM8 and Bach2 were positively correlated (r=7.142, P=0.009). The levels of TLR8, TRPM8 and Bach2 were positively correlated with the recurrence of chronic rhinosinusitis with nasal polyps after endoscopic surgery (P<0.05). Conclusion There is a certain correlation between the recurrence of chronic rhinosinusitis with nasal polyps after endoscopic surgery and the expression of TLR8, TRPM8 and Bach2, which are highly expressed in the disease.

Key words: Chronic rhinosinusitis with nasal polyp, Endoscopy, Toll-like receptor 8

摘要： 目的 探究TLR8、TRPM8、Bach2表达与慢性鼻-鼻窦炎伴鼻息肉（CRSwNP）术后复发的关系。方法 选取2021年6月至2023年6月于濮阳市安阳地区医院接受内窥镜手术的CRSwNP患者120例,于术后1年统计术后复发情况,发现有6例遗失,据统计发现术后复发患者为66例,选取其作为研究组,并选取剩余48例未复发患者为对照组,根据疾病严重程度分为轻度组(Lund-Mackay评分<4分)19例,中型组Lund-Mackay评分4~15分)17例,重型组(Lund-Mackay评分>15分)13例。对比2组患者TLR8、TRPM8、Bach2表达情况,分析三者与CRSwNP内窥镜术后复发的相关性。结果 研究组TLR8、TRPM8、Bach2表达水平、炎症因子水平高于对照组（P<0.05）;与轻型组相比,中型组、重型组TLR8、TRPM8、Bach2表达水平高于轻型组（P<0.05）;与中型组相比,重型组TLR8、TRPM8、Bach2表达水平高于中型组（P<0.05）;与重型组相比,轻型组TLR8、TRPM8、Bach2表达水平低于重型组（P<0.05）。CRSwNP内窥镜术后复发患者TLR8、TRPM8水平呈正相关（r=7.964,P=0.006）;TLR8、Bach2水平呈正相关（r=10.640,P=0.001）;TRPM8、Bach2水平呈正相关（r=7.142,P=0.009）。TLR8、TRPM8、Bach2水平与CRSwNP内窥镜术后复发呈正相关存在（P<0.05）。结论 CRSwNP内窥镜术后复发与TLR8、TRPM8、Bach2表达存在一定相关性,在疾病中呈现高表达。

关键词: 慢性鼻-鼻窦炎伴鼻息肉, 内窥镜术, Toll样受体8