Abstract: Objective To investigate the value of combined detection of carboxylpeptidyme X-M14 family member 1 (CPXM1), laminin subunit β3 (LAMβ3) and homeogenin-like protein 2 (FMNL2) in predicting postoperative recurrence in gastric cancer patients. Methods A total of 107 patients with gastric cancer admitted to the Fifth People's Hospital of Jiaozuo from January 2021 to April 2023 were selected as research objects, patients were divided into a recurrence group (n=24) and a non-recurrence group (n=83) according to their recurrence within 1 year after surgery. And different pathological features and cancer tissue levels of CPXM1, LAMβ3 and FMNL2 were compared between the two groups and their correlation was analyzed, the influencing factors of the gastric cancer patients' postoperative recurrence and their predictive value of the patients' postoperative recurrence were analyzed. Results In the recurrent group, the proportions of T3~T4 depth of invasion, poorly differentiated tumors, and lymph node metastasis, as well as the levels of LAMβ3 mRNA and FMNL2 mRNA in cancer tissues, were all higher than those in the non-recurrent group. Meanwhile, the level of CPXM1 mRNA was lower than that in the non-recurrent group (P<0.05). The level of CPXM1 mRNA in cancer tissues was negatively correlated with TNM staging, lymph node metastasis, and depth of invasion, and positively correlated with the degree of differentiation. Both LAMβ3 and FMNL2 in cancer tissues were positively correlated with TNM staging, lymph node metastasis, and depth of invasion, and negatively correlated with the degree of differentiation (P<0.05). TNM stage III, lymph node metastasis, depth of invasion, LAMβ3, and FMNL2 in cancer tissues were risk factors for postoperative recurrence in patients, while the degree of differentiation and CPXM1 mRNA in cancer tissues were protective factors (P<0.05). The combined CPXM1, LAMβ3 and FMNL2 levels predicted postoperative recurrence of patients with AUC of 0.811, which was higher than that detected by each index alone (P<0.05). Conclusion The changes of CPXM1, LAMβ3 and FMNL2 levels in cancer tissue can provide reference data for the prediction of postoperative recurrence of gastric cancer, and the combined detection has higher clinical application value.

Key words: Cancer tissue, Cpxm1, LAMβ3, Fmnl2, Postoperative recurrence

摘要： 目的 探讨胃癌组织羧基肽酶X-M14家族成员1（CPXM1）、层粘连蛋白亚基β3（LAMβ3）、同源形成素样蛋白2（FMNL2）水平联合检测对患者术后复发的预测价值。方法 选取焦作市第五人民医院2021年1月~2023年4月收治的107例胃癌患者为研究对象,根据患者术后1年内复发情况分为复发组（n=24）及未复发组（n=83）,对比2组不同病理特征及癌组织CPXM1、LAMβ3、FMNL2水平并分析其相关性,分析胃癌患者术后复发的影响因素及其对患者术后复发的预测价值。结果 复发组T3~T4浸润深度比例、低分化比例、有淋巴结转移比例及癌组织LAMβ3 mRNA、FMNL2 mRNA水平均高于未复发组、CPXM1 mRNA水平低于未复发组（P<0.05）;癌组织CPXM1 mRNA水平与TNM分期、淋巴结转移、浸润深度均呈负相关,与分化程度呈正相关,癌组织LAMβ3、FMNL2均与TNM分期、淋巴结转移、浸润深度均呈正相关,与分化程度呈负相关（P<0.05）;TNM分期Ⅲ期、淋巴结转移、浸润深度、癌组织LAMβ3、FMNL2为患者术后复发的危险因素,分化程度、癌组织CPXM1为患者术后复发的保护因素（P<0.05）;入院时癌组织CPXM1、LAMβ3、FMNL2水平联合预测患者术后复发的AUC为0.811,均高于各指标单独检测（P<0.05）。结论 癌组织CPXM1、LAMβ3、FMNL2水平变化可为胃癌术后复发的预测提供参考数据,且联合检测在临床中的应用价值更高。

关键词: 癌组织, CPXM1, LAMβ3, FMNL2, 术后复发