Journal of Chengde Medical University ›› 2025, Vol. 42 ›› Issue (4): 324-328.

Received:2024-09-10 Online:2025-08-10 Published:2025-08-19

阿尔茨海默病与糖尿病的相关性研究进展

宋伟玲¹, 薛君^2,3,*, 武学慧¹, 贺佳丽¹

1.内蒙古科技大学包头医学院研究生院,内蒙古包头 014040;
2.乌兰察布市中心医院老年医学科,内蒙古乌兰察布 012000;
3.内蒙古包钢医院老年医学科,内蒙古包头 014010

通讯作者: *
基金资助:
内蒙古自然科学基金项目（2024LHMS08073）; 内蒙古公立医院科研联合基金科技项目（2023GLLH0247）; 中国金属学会冶金安全与健康分会健康卫生科研项目（jkws202028）; 包头市卫生健康科技计划项目（wsjkkj098）

Abstract

关键词: 阿尔茨海默病, 糖尿病, 相关性, 流行病学

CLC Number:

R749.1

宋伟玲, 薛君, 武学慧, 贺佳丽. 阿尔茨海默病与糖尿病的相关性研究进展[J]. 承德医学院学报, 2025, 42(4): 324-328.

Add to citation manager EndNote|Ris|BibTeX

URL: http://tougao.cdmc.edu.cn:8088/EN/

http://tougao.cdmc.edu.cn:8088/EN/Y2025/V42/I4/324

[1] 汪睿彤,刘珏. 阿尔茨海默病的流行病学研究进展[J]. 中国慢性病预防与控制,2021,29(9):707-711.
[2] Kellar D, Craft S.Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches[J]. Lancet Neurol, 2020, 19(9): 758-766.
[3] Burillo J, Marqués P, Jiménez B, et al.Insulin resistance and diabetes mellitus in Alzheimer's disease[J]. Cells, 2021, 10(5): 1236.
[4] Diehl T, Mullins R, Kapogiannis D.Insulin resistance in Alzheimer's disease[J]. Transl Res, 2017, 183: 26-40.
[5] Biundo F, Del Prete D, Zhang H, et al.A role for tau in learning,memory and synaptic plasticity[J]. Sci Rep, 2018, 8(1): 3184.
[6] Sharma VK, Singh TG.Insulin resistance and bioenergetic manifestations:Targets and approaches in Alzheimer's disease[J]. Life Sci, 2020,(262): 118401.
[7] Arnold SE, Arvanitakis Z, Macauley-Rambach SL, et al.Brain insulin resistance in type 2 diabetes and Alzheimer disease:Concepts and conundrums[J]. Nat Rev Neurol, 2018, 14(3): 168-181.
[8] Burillo J, Marqués P, Jiménez B, et al.Insulin Resistance and Diabetes Mellitus in Alzheimer's Disease[J]. Cells, 2021, 10(5): 1236.
[9] Grochowski C, Litak J, Kamieniak P, et al.Oxidative stress in cerebral small vessel disease.Role of reactive species[J]. Free Radic Res, 2018, 52(1): 1-13.
[10] Kabir MT, Uddin MS, Zaman S, et al.Molecular mechanisms of metal toxicity in the pathogenesis of Alzheimer's disease[J]. Mol Neurobiol, 2021, 58: 1-20.
[11] 王准,孙谕莹,黄汉昌. 氧化应激与阿尔茨海默病的病理关系及干预措施[J]. 生命科学,2023,35(4):519-528.
[12] 魏书瑶,冯珊珊,马菲菲,等. 氧化应激在2型糖尿病发生发展中的作用机制[J]. 西北国防医学杂志,2021,42(6):557-562.
[13] Shan Z, Fa WH, Tian CR, et al.Mitophagy and mitochondrial dynamics in type 2 diabetes mellitus treatment[J]. Aging (Albany NY), 2022, 14(6): 2902-2919.
[14] Giovannini MG, Scali C, Prosperi C, et al.β-Amyloid-Induced Inflammation and Cholinergic Hypofunction in the Rat Brain in Vivo: Involvement of the p38MAPK Pathway[J]. Neurobiol Dis, 2002, 11(2): 257-274.
[15] 陈凯丽,李海琦,王俏丽,等. 阿尔茨海默病中神经炎症相关生物标志物的研究进展[J]. 中国实验诊断学,2023,27(1):89-92.
[16] Akhtar A, Sah SP.Insulin signaling pathway and related molecules: Role in neurodegeneration and Alzheimer's disease[J]. Neurochem Int, 2020, 135: 104707.
[17] Ebrahimpour S, Zakeri M, Esmaeili A.Crosstalk between obesity, diabetes, and alzheimer's disease: Introducing quercetin as an effective triple herbal medicine[J]. Ageing Res Rev, 2020, 62: 101095.
[18] Zeppa SD, Agostini D, Gervasi M, et al.Mutual interactions among exercise, sport supplements and microbiota[J]. Nutrients, 2019, 12(1): 17.
[19] Sherwin E, Dinan TG, Cryan JF.Recent developments in understanding the role of the gut microbiota in brain health and disease[J]. Ann N Y Acad Sci, 2018, 1420(1): 5-25.
[20] Le Page A, Dupuis G, Frost EH, et al.Role of the peripheral innate immune system in the development of Alzheimer's disease[J]. Exp Gerontol, 2018, 107: 59-66.
[21] Lukiw WJ, Arceneaux L, Li W, et al.Gastrointestinal (GI)-Tract microbiome derived neurotoxins and their potential contribution to Inflammatory neurodegeneration in Alzheimer's disease (AD)[J]. Alzheimers Dis Parkinsonism, 2021, 11(6): 525.
[22] 丁珊珊,刘星玥,马浩. 晚期糖基化终末产物介导糖尿病慢性并发症的分子机制研究进展[J]. 江苏医药,2020,12(2):202-206.
[23] Batkulwar K, Godbole R, Banarjee R, et al.Advanced glycation and products modulate amyloidogenic APP processing and tau phosphorylation:a mechanistic link between glycation and the development of Alzheimer's disease[J]. ACS Chem Neurosci, 2018, 9(5): 988-1000.
[24] Patterson SA, Deep G, Brinkley TE.Detection of the receptor for advanced glycation endproducts in neuronally-derived exosomes in plasma[J]. Biochem Biophys Res Commun, 2018, 500(4): 892-896.
[25] Kellar D, Craft S.Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches[J]. Lancet Neurol, 2020, 19(9): 758-766.
[26] Bohlken J, Jacob L, Kostev K.Association Between the Use of Antihyperglycemic Drugs and Dementia Risk: A Case-Control Study[J]. J Alzheimers Dis, 2018, 66(2): 725-732.
[27] Ning P, Luo A, Mu X, et al.Exploring the dual character of metformin in Alzheimer's disease[J]. Neuropharmacology, 2022, 207: 108966.
[28] Farr SA, Roesler E, Niehoff ML, et al.Metformin Improves Learning and Memory in the SAMP8 Mouse Model of Alzheimer's Disease[J]. J Alzheimers Dis, 2019, 68(4): 1699-1710.
[29] Lee JH, Jahrling JB, Denner L, et al.Targeting Insulin for Alzheimer's Disease: Mechanisms, Status and Potential Directions[J]. J Alzheimers Dis, 2018, 64(s1): S427-S453.
[30] McClean PL, Hölscher C. Liraglutide can reverse memory impairment, synaptic loss and reduce plaque load in aged APP/PS1 mice, a model of Alzheimer's disease[J]. Neuropharmacology, 2014, 76 Pt A: 57-67.
[31] Angelopoulou E, Piperi C.DPP-4 inhibitors: a promising therapeutic approach against Alzheimer's disease[J]. Ann Transl Med, 2018, 6(12): 255.

阿尔茨海默病与糖尿病的相关性研究进展

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 7

Recommended Articles

Metrics

Comments

[1]	DONG Xu-ting, CAI Han, XU Hui, PAN Qin, LI Shi-xia. The Mediating Effect of Serum Vitamin D₃ Level on The Degree of Depression and Cognitive Function in Elderly People with MCI [J]. Journal of Chengde Medical University, 2025, 42(3): 186-190.
[2]	GE Nian-nian, YAN Xiang-min, YAN Ru-bing, LIU Jian-jun. Expressions and Clinical Significance of Serum HIF-1α, sFas and Livin in Elderly VaD [J]. Journal of Chengde Medical University, 2022, 39(3): 200-204.
[3]	HUO Yan. Effects of Mouse Nerve Growth Factor Combined with Donepezil in the Treatment of Alzheimer's Disease [J]. Journal of Chengde Medical University, 2021, 38(6): 471-475.
[4]	XU Gui-lan, WANG Juan, LONG Jiu-an. Application Effect of Ginkgo Leaf Combined with Oxiracetam on Patients with Non-Dementia Vascular Cognitive Impairment [J]. Journal of Chengde Medical University, 2021, 38(5): 395-400.
[5]	. [J]. Journal of Chengde Medical University, 2021, 38(4): 330-332.
[6]	ZHANG Zi-long, WANG Zhi-cheng, DONG Yi-feng, WANG Rui-ting. Effects of Hesperetin Early Prevention on Learning Memory Ability and TLR2、NF-kB Expression in APPswe/PS1dE9 Double Transgenic Mice [J]. Journal of Chengde Medical University, 2020, 37(3): 188-191.
[7]	. [J]. Journal of Chengde Medical University, 2022, 39(1): 54-57.