Abstract: Objective To explore the effects of mouse nerve growth factor (mNGF) combined with donepezil in the treatment of Alzheimer's disease (AD). Methods A total of 72 AD patients who were admitted to the hospital from April 2016 to August 2019 were enrolled as the research subjects. They were randomly divided into study group and control group, 36 cases in each group. The control group was treated with oral donepezil, while study group was treated with mNGF and donepezil. The cognitive function before and after treatment, contents of serum amyloid beta protein (Aβ1-42), Chitinase protein 40 (YKL-40) and Derived neurotrophic factor (BDNF), and inflammatory factors [C-reactive protein (CRP), interleukin 1-β (IL-1β), tumor necrosis factor α (TNF-α)] were compared between the two groups. The curative effect was analyzed and compared between the two groups. Results After treatment, total response rate of study group was higher than that of control group (77.78% vs 55.56%, P<0.05). After treatment, ADAS-cog score in study group was lower than that in control group, while scores of MMSE and ADL were higher than those in control group (P<0.05). After treatment, levels of Aβ1-42, YKL-40, CRP, IL-1β and TNF-α in study group were lower than those in control group, while BDNF level was higher than that in control group (P<0.05). There was no significant difference in incidence of adverse reaction between the two groups (P>0.05). Conclusion The mNGF combined with donepezil can improve cognitive function of AD patients, reduce the inflammatory factors, which has a certain clinical effect on AD.

Key words: mouse nerve growth factor, Alzheimer's disease, Aβ1-42;, YKL-40, BDNF

摘要： 目的 探讨鼠神经生长因子（mNGF）联合多奈哌齐治疗老年痴呆（AD）的效果。方法 选择2016年4月~2019年8月我院接收的72例AD患者作为试验对象,随机分为研究组与对照组,每组36例。对照组给予口服多奈哌齐治疗,研究组在此基础上联合mNGF治疗。对两组患者治疗前后认知功能进行比较,对血清β淀粉样蛋白（Aβ1-42）、甲壳质酶蛋白40（YKL-40）、脑源性神经营养因子（BDNF）含量及炎症因子C-反应蛋白（CRP）、白细胞介素1-β（IL-1β）、肿瘤坏死因子α（TNF-α）含量进行测定比较,分析比较两组治疗效果。结果 研究组治疗后总有效率为77.78%,高于对照组的55.56%（P<0.05）;研究组治疗后ADAS-cog评分较对照组降低,MMSE、ADL评分较对照组升高（P<0.05）;研究组治疗后Aβ1-42、YKL-40、CRP、IL-1β、TNF-α水平较对照组降低,BDNF水平较对照组升高（P<0.05）;两组不良反应产生率无明显差异（P>0.05）。结论 mNGF联合多奈哌齐治疗能够提高AD患者认知功能,减轻炎症反应,对AD具有一定的临床疗效。

关键词: 鼠神经生长因子, 老年痴呆, Aβ1-42;, YKL-40, BDNF