ISSN 1004-6879

CN 13-1154/R

 

Journal of Chengde Medical University ›› 2023, Vol. 40 ›› Issue (4): 294-297.

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Relationship between 25-hydroxyvitamin D and GH/IGF-1 Axis in Children with Short Stature

SHI Shu-xia1, PENG Wu2,*   

  1. 1. Clinical Medical College of Anhui Medical College, Hefei, Anhui, 230601, China;
    2. The Second Affiliated Hospital of Anhui Medical University
  • Received:2022-11-16 Online:2023-08-10 Published:2023-09-15

矮小症儿童25羟维生素D与GH/IGF-1轴的关系研究

石淑霞1, 彭武2,*   

  1. 1.安徽医学高等专科学校临床医学院,安徽合肥 230601;
    2.安徽医科大学第二附属医院
  • 通讯作者: *

Abstract: Objective To compare the levels of 25-hydroxyvitamin D[25-(OH)D] in children with growth hormone deficiency (GHD) and idiopathic short stature (ISS), and to study its relationship with the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis. Methods A total of 138 children with GHD and 199 children with ISS were selected. The levels of 25-(OH)D and the proportion of vitamin D deficiency were compared between the two groups. The correlation factors of 25-(OH)D in children with short stature were analyzed, and a multivariate linear regression model with IGF-1 as the dependent variable was established. Result sThe level of 25-(OH)D in GHD group was higher than that in ISS group, and the difference was statistically significant (P<0.05). The proportion of 25-hydroxyvitamin D deficiency and insufficiency in ISS group was higher than that in GHD group, the difference was statistically significant (χ2 = 5.966, P=0.015). 25-(OH)D was negatively correlated with age, body mass index (BMI), IGF-1, insulin-like growth factor binding protein-3 (IGFBP-3) and growth hormone peak (GHpeak) (P<0.05), and positively correlated with bone age index (BAI)(P<0.05). There was no correlation with gender (P>0.05). Multivariate linear regression model showed that age, BMI and BAI were the influencing factors of IGF-1 (P<0.05), while 25-(OH)D did not constitute the influencing factors of IGF-1 (P>0.05). Conclusion Insufficient or deficient vitamin D is common in ISS and GHD children, especially in ISS children. 25-(OH)D does not constitute a factor in the GH/IGF-1 axis in children with short stature, and routine vitamin D supplementation is recommended for GHD and ISS children, but not as an alternative to recombinant human growth hormone therapy.

Key words: 25-hydroxyvitamin D, dwarfism, growth hormone/insulin-like growth factor-1 axis, growth hormone deficiency, idiopathic short stature

摘要: 目的 比较生长激素缺乏症(GHD)、特发性矮身材(ISS)儿童的25羟维生素D[25-(OH)D]水平,研究其与生长激素/胰岛素样生长因子-1(GH/IGF-1)轴的关系。方法 选取GHD患儿138例、ISS患儿199例,对比2组25-(OH)D水平、维生素D缺乏的比例。分析矮小症儿童25-(OH)D的相关因素,建立IGF-1为因变量的多因素线性回归模型。结果 GHD组儿童25-(OH)D水平高于ISS组,差异有统计学意义(P<0.05)。ISS组25羟维生素D缺乏和不足的比例高于GHD组,差异有统计学意义(χ2=5.966,P=0.015)。25-(OH)D与年龄、体质量指数(BMI)、IGF-1、胰岛素样生长因子结合蛋白-3(IGFBP-3)、生长激素峰值(GHpeak)呈负相关(P<0.05),与骨龄指数呈正相关(P<0.05),与性别无相关性(P>0.05)。多因素线性回归模型显示,年龄、BMI、骨龄指数是IGF-1的影响因素(P<0.05),25-(OH)D不构成IGF-1的影响因素(P>0.05)。结论 ISS和GHD儿童常见维生素D不足或缺乏,ISS儿童更明显。矮小症儿童25-(OH)D不构成GH/IGF-1轴的影响因素,GHD和ISS儿童建议常规补充生理需要量的维生素D,但不能作为重组人生长激素(rhGH)治疗的替代选择。

关键词: 25羟维生素D, 矮小症, 生长激素/胰岛素样生长因子-1轴, 生长激素缺乏症, 特发性矮身材

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