Abstract: Objective To investigate the predictive value of triglyceride glucose product index in the incidence of coronary heart disease in non-diabetic people. Methods In this study, a total of 186 patients who were hospitalized in the Department of Cardiology, Affiliated Hospital of Chengde Medical University from February 2021 to February 2022 and met the inclusion criteria were selected as the study subjects, and were divided into coronary heart disease group and control group according to the results of coronary angiography. The baseline data, fasting blood lipid and blood glucose levels of the patients in both groups were recorded, and the triglyceride glucose product index was calculated. Multivariate logistic regression was used to analyze the incidence of triglyceride glucose product index on coronary heart disease in non-diabetic people, and the receiver operator characteristic (ROC) curve predicted the predictive value of triglyceride glucose product index for coronary heart disease in non-diabetic people. Results The proportion of hypertension history, smoking, triglyceride glucose product index and total cholesterol level in the coronary heart disease group were significantly higher than those in the control group (P<0.05). Multivariate logistic regression analysis showed that the triglyceride glucose product index, total cholesterol, smoking, and hypertension were independent risk factors for the onset of coronary heart disease in non-diabetic patients (P<0.05) . The ROC curve showed that the area under the curve of triglyceride glucose product index predicting the onset of coronary heart disease in non-diabetic people was 0.804 (95% CI: 0.714~0.780, P<0.05). Conclusion The triglyceride glucose product index was positively correlated with the Gensini score, which has certain predictive value for the incidence of coronary heart disease in non-diabetic people.

Key words: triglyceride glucose index, coronary atherosclerotic heart disease, insulin resistance

摘要： 目的 探讨甘油三酯葡萄糖乘积指数对非糖尿病患者冠心病发病的预测价值。方法 选取2021年2月~2022年2月于承德医学院附属医院心血管内科住院并符合纳入标准的186例患者作为研究对象,依据冠状动脉造影结果分为冠心病组和对照组。记录2组患者的基线资料、空腹血脂及血糖水平,计算甘油三酯葡萄糖乘积指数。采用多因素Logistic回归分析甘油三酯葡萄糖乘积指数对非糖尿病患者冠心病的发病情况,受试者工作特征（ROC）曲线预测甘油三酯葡萄糖乘积指数对非糖尿病患者冠心病发病的预测价值。结果 冠心病组高血压史、吸烟的比例,甘油三酯葡萄糖乘积指数、总胆固醇水平高于对照组,差异有统计学意义（P<0.05）;多因素Logistic回归分析结果显示,甘油三酯葡萄糖乘积指数、总胆固醇、吸烟、高血压是非糖尿病患者冠心病发病的独立危险因素（P<0.05）。ROC曲线显示,甘油三酯葡萄糖乘积指数预测非糖尿病患者冠心病发病的曲线下面积为0.804（95% CI：0.714~0.780,P<0.05）。结论 甘油三酯葡萄糖乘积指数冠心病发病呈正相关,对非糖尿病患者的冠心病发病有一定的预测价值。

关键词: 甘油三酯葡萄糖乘积指数, 冠心病, 胰岛素抵抗